Non-surgical permanent female tubal sterilization using Methylcyanoacrylate (MCA) was studied in 25 volunteers. The results are; 1. In the first MCA applications, bilateral tubal closure were 18 patients (72%), unilateral tubal closure were 4 patients(16%), and 3 patients were noted as bilateral tubal patentcy. 2. In the second MCA application with 3 unilateral tubal closure patients were all successful. 3. The total success rate after first and second MCA application were 100% (total 21 cases). 4. There were no specific subjective symptoms at the time of application, and there were no significant changes in menstrual, urinary and bowel functions. 5. It is concluded that the use of MCA in non-surgical permanent female sterilization is highly effective, safe and simple. so this methods of female sterilization would greatly contribute the national Family Planning Programs.