저자들은 난소암의 진단 및 예후측정을 위하여 1977년 10월1일부터 1979년 8월 31일까지 가톨릭의대 부속 성모병원 산부인과에 입원 및 치료를 하였던 27에의 난소암 환자중 수술 전 hCG b-subunit 및 AFP 방사면역 측정상 양성의 치를 나타내었던 11예, 4예를 대상으로 하여 추적검사를 한 결과 다음과 같은 결론을 얻었다. 1.난소암 환자중 hCG b-subunit치에 양성인 경우는 11예(40.7%)였으며 AFP치에 양성인 경 우는 4예(14.8%)로서 hCG b-subunit에 비교적 높은 양성율을 나타냈다. 2.hCG b-subunit측정상 최초 역가는 예후 양호예에서는 79.3mlU/ml, 불량 예에서는 2765.3 mlU/ml이상이었으며 AFP 측정상 전자는 40.5ng/ml, 후자는 220.3ng/ml이상이었다. 3.hCG b-subunit 측정상 양성인 예에서 혈중 음전화까지 소요시간은 예후 양호 예에서 평균 17.1일로 급격한 하강을 보이나, 불량 예에서는 111일 이상으로 지연된 하강을 보였다. AFP 측정상 음전화까지 소요시간은 예후 양호예어서는 평군21.0일, 불량 예어서 80일이었으나 신빙도는 hCG b-subunit치보다 적었다. 4.이상으로서 hCG b-subunit와 AFP측정상 4주이내에 음전화시는 예후 양호예, 4주 이상 소 요시는 예후 불량 예로 추측할 수 있었다. 5.난소암 환자에서 이와 같은 hCG b-subunit 및 AFP 방사면역 측정상 진단적 의의는 적으 나 종양표지(tumor marker) 물질로서 수술 전 양성이었던 예를 추적검사 함으로서 그 예후를 판정할 수 있으리라 생각된다.

It is diffiicult to presict prognosis and to diagnose remission of ovarian malign- ancy because these patients take variable clinical course. Recently attention was foxused on carcinoembryonic antigen(CEA) and a-fetop- rotein, human placental lactogen, hCG b-subunit and pregnancy specific b globulin as specific marlers of neoplasms. Quantitative serial measurement of plasma hCG b-subunit and a-fetoprotein levels as a marker using sensitive double-antibodt radioimmunoassays were performed in 27 patients with ovarian malignaacy from. 1. Oct., 1977 to 31. Aug., 1979 mat the Department of Obstetrics and Gynecology, St. Mary`s Hospital, Catholic Medical School, for prediction of the prognosis after definitive therapy. These patients were stusied before and after operation and during cgemotherapy. For the pur- pose of the establishment of the standard level of a-fetoprotein in plasma, 40 non-pregnant healthy women were selectes as a control group, randomly. The results were as follows: 1.Out of 27 patients with ovarian malignancy, the percentages of patients with a positive level of hCG b-subunit and a- fetoprotein in plasma were 40.7 per cent (11 patients) and 14.8 percent (4 patient), respectively. 2.The mean value of inital hCG b-subinit was 79.3mlU/ml in the good prognosis group and 2765.3mlU/ml in the bad prognosis group. And the mean value of intial a-fetoprotein level was 40.5ng/ml in the former and 220.3ng/ml in the latter group. 3.The mean days requiring for conversion from positive to negative level of hCG b-subunit level were 17.1 days in the good prognosis group and over 111 days in the bad prognosis group. And the mean days were 21.0 days in the former and over 80 days in the latter for the a-fetoprotein. 4.We could suspect that if the tumor markers were not detected in 4 weeks after operation, the prognosis would be good while if they were detected ovwe 4 weeks after operation the pergnosis would be bad. 5.The significance of measuremeny of hCG b-subunit and a-fetoprotein in patients with ovarian malignancy was not valuable in the diagnosis of the disease but we could perdict the prognosis of the patients by serial measurement of the level of tumor markers before and after operation and during chemotherapy.