저자들은 Trichomonas vaginalis 감염과 자궁경부암과의 연관성을 조사하기 위하여 1978년 1월부터 1978년 12월까지의 카톨릭의과대학 부속 성모병원에서 Trichomonas vaignalis에 심하게 감염된 48명을 대상으로 질확대경 검사를 실시하였고 이중 30명은 조준 생검을 시행하여 관찰한 결과 다음과 같은 결론을 얻었다. 1. Trichomonas vaginalis 감염으로 인한 자궁경부의 변화는 질확대경상 특이한 변화를 나타낸다. 2. Trichomonas vaginalis 감염시 악성변화의 가능성이 많은 질확대경진 분류상 제Ⅳ형의 병변상을 가장 많이 볼 수 있었다. 3. Trichomonas vaginalis 감염시 병리조직변화는 상피층의 혈관증식, 세포내 공포의 증가, 기저세포 증식과 자궁경관내 세포의 편평상피 화생을 많이 볼 수 있다. 4. Trichomonas vaginalis 감염과 자궁경부암 발생간에는 연관성이 있는 것으로 생각된다.

Trichomonas vaginalis, first described by Donn , 1836, for many years has been associated with lesions of the female genital tract. The frequent coexistence of trichomonal cervicitis and cervical cancer has caused much speculation concerning a possible etiologic relationship. It is our purpose for this study to evaluate the relationship between trichomonas-induced inflammatory change and carcinogenesis in the uterine cervix. From January 1978 through December 1978, colposcopic examinations were taken in a series of 346 patients. Among them, we selected the trichomonal cervicitis, 30 cases, who were taken colposcopic examination and biopsy for the evaluation of the trichomonal cervicitis and its relationship to cervical precancerous lesion. The results were as follows; 1. The presence of large areas of "double-crested capillaries" is a very strong indication of active trichomonal infection. 2. The trichomonal cervicitis is found in 30 patients; 15(50.0%) of whom are cases of class Ⅳ colposcopic classification, and 2 of class Ⅴ that are precancerous lesion. 3. Increased vascularity of the squamous epithelium appeared to be by far the most sensitive index of structural alterations associated with trichomonas. Intracellular vacuolization, squamous metaplasia of endocervical lining cell and basal cell hyperplasia were also noted. 4. There is evidently and association between cervical carcinoma and infestation with Trichomonas vaginalis, although a direct causal relationship is unproved. * This paper was supported by Clinical Research Fund of Catholic Medical Center & Roche Far East Research Foundation. ** Prof and Chairman, Dept of Obstetrics and Gynecology. *** Assistant Prof., Dept of Clinical Pathology.