1972년 1월 1일부터 1975년 12월 31일까지 만 4년간 이화대학병원 산부인과에서 분만한 총수 6290예중 자연조기파막 482예를 임상적으로 분석 관찰하여 다음과 같은 결론을 얻었다. 1) 자연조기파막의 발생빈도는 7.7%였다. 2) 조산의 빈도는 17.6%로서 경산부에서 많았으며(26.5%) 초산부(12.3%)보다 약 2배로 높았다. 3) 모체측에 합병된 질환은 23.6%로서 이중 임신중독증이 13%로 약 반수를 차지했다. 4) 파막후 24시간 이상을 초과한 환자는 산모측의 산후발열이 시간에 정비례하여 높았다. 동시에 신생아의 이환율도 높았으므로 가급적 조기파막된 임부는 24시간내에 분만시키는 것이 좋다. 5) 신생아의 이환율 및 주산기 사망율(교정사율(corrected death rate)은 4.6%)은 분만전 항생제치료로서는 개선시킬 수 없었다. 6) 그러나 파막직후 또는 입원즉시에 투여하기 시작한 예방적 항생제치료는 산모의 이환율 및 재원치료소요기간을 현저히 감소시켰다.

The management of spontaneous premature rupture of membranes is still remain controversial as far as the use of prophylactic antibiotics or timing of delivery is concern. The data presented here are based on the 482 cases of premature rupture of membranes among 6290 deliveries at the Department of Obstetrics and Gynecology, Ewha Womans University Hospital from January 1, 1972 to December 31, 1975. The policy of delivery, maternal and newborn morbidity and the effect of prophylactic antibiotics treatment were discussed. The results obtained as follows; 1) The incidence of premature rupture of membranes was 7.7% or 482 cases of 6290 deliveries. 2) The incidence of prematurity was 17.6% and it was figured that twice in the multiparas(26.5%) than in the primiparas(12.3%). 3) The associated maternal disease was 23.6% of the cases in the premature rupture of membranes and the main maternal disease was toxemia of pregnancy(13%). 4) Postpartum maternal fever and newborn morbidity were increased in proportion to the duration of the premature rupture of membranes, particularly when it exceeded over 24 hours. It is our experienced that the optimal delivery should be accomplished within 24 hours after premature rupture of membranes as possible. 5) Even with regular antepartum antibiotic treatments in the cases of premature rupture of membranes, any changes or reduction of the newborn morbidity or perinatal mortality could not be expected. 6) When prophylactic antibiotics treatment was used, the maternal morbidity and duration of antibiotics treatment needed in postparum were reduced markedly.