1976년 3월부터 1977년 2월까지 12개월간 고려대학교 의과대학 부속병원 산부인과에 의학적 및 기타 적응증으로 중기임신중절을 목적으로 입원한 28예에 대하여 prostaglandin F₂α의 간헐적 양막외 주입법을 시행하여 유산을 성공하였으며 그 결과를 조사분석하여 다음과 같은 결론을 얻었다. 1) Prostaglandin F₂α의 주입에서 부터 유산까지의 평균 소요시간은 18.89시간이 었다. 초산부에서는 평균 21.19시간, 경산부에서는 평균 17.41시간이 소요되었으며 경 산부에서 초산부보다 약간 빠른 것을 볼수 있었다. 2) Prostaglandin F₂α의 주입량은 최소 1,500㎍에서 최대 11,250㎍까지 였으며, 초산부에서는 평균 5036.36㎍, 경산부에서는 평균 4035.29㎍이 주입되었다. 3) 유산성공율은 24시간내에 85.7%의 성공율을 보여 주었고, 36시간내에 100%의 성공율을 보여 주었다. 4) 중기임신중절의 적응증중 정신사회적 문제가 16예로 가장 많았고, 자궁내태아사 망이 4예를 차지했다. 5) 부작용은 오심, 구토, 설사 등 소화기계통의 장애(14.3%)가 가장 많았고, 악한과 발열반응이 각각 1예 있었다. 6) 가장 흔한 합병증은 불완전유산(25%)이었고, 소파수술과 용수박리 등으로 태반 조직을 제거하였다.

The use of prostaglandin F2α administered by extra-ovular infusion through foley catheter for the induction of abortion was studied in 28 patients between 16 and 28 weeks gestation. No serious complications occurred. Some minimal side effects were observed. Occasional vomiting was the commonest symptom but the incidence of side effects was lower than with alternative routes of administration. Side effects were in general well tolerated by the patients and never required therapy or termination. There were 4 cases of incomplete abortion with over 250ml, of estimated blood loss, but transfusion was not required. The method has proved a safe and effective means of terminatimg pregnancies in the second trimester. The results were obtained as follow; 1. The mean abortion time from infusion to the abortion of the fetus was 18.89 hours. The mean abortion time for the multiparas was 17.41 hours, somewhat lower than the mean time for the primiparas of 21.19 hours, but this difference was not statistically significant. 2. the mean total dosage of prostaglandin F2α was 5036.36 ug in primiparas and 4035.29 ug in multiparas. 3. The abortion was successfully induced in 85.7% of patients within 24 hours and in 100% within 36 hours. 4. The most common indication of mid-trimester abortion was psychological problem in 16 cases, next was intraurteine fetal death in 4 cases. 5. the most common side effects consisted of gastrointestinal sysptoms(14.3%) such as nausea, vomiting and diarrhea. Other side effects included transient pyrexia and chilling. 6. The most common disadvantage was incomplete abortion. In 75% of patients, abortion was complete but in 255 of patients was incomplete. These were managed by dilatation and evacuation or manual removal of the placenta.