가토의 난관에 인위적 압착손상을 가한 후 섬유소용해성, 단백분해 효소들을 경구 또는 정 맥내 투여하여 그 병리조직학적 관찰을 통하여 다음과 같은 결론을 얻었다. 1) 난관 전층에 있어서 울혈, 삼출 및 섬유소증식 등 감소의 정도가 효소제의 투여군에서 보다 현저하였다. 2) 난관강내 출물의 흡수는 효소제의 투여군에서 대조군 보다 현저히 증가되었다. 3) 효소제의 투여군에 있어서는 상피의 증식과 점액생산능이 대조군에서 보다 양호함을 알 수 있었다. 4) Bromelain과 trypdin 및 chymotrypsin과 trypsin을 투여한 군에서 타 투여군보다 섬유소 용해작용이 현저하며, 울혈, 삼출 및 섬유소증식 등이 더욱 감소되는 것으로 나타났다.

Artificial crushing injuries were made on the salpinges of rabbits and streptokinase-streptocornase, trypsin and bromelain, chymotrypsin and trypsin, and alpha-chymotrypsin were given to rabbits. Fibrinolytic and proteolyties of these enzymes were studied by histopathological evaluation of salpinges and were compared with those in the control group. The results were as follows: 1) Congestion, exudation and fibrosis were much less in treated groups than control control group. 2) The absorption of intraluminal exudation was more prominent in treated groups than in control group. 3) Hyperplasia and mucin producing activity of luminal epithelium were almost same as normal salpinx in all cases. 4) Groups treated with bromilain and trypsin, and chymotrypsin and trypsin respectively, were more effective in fibrinolysis and absorption of congestion and exudation than others.