1) 과소월경, 희발과소월경을 가진 무배란성주기의 2예의 자궁발육부전증인데 제1예는 대량 Estrogen(90mg) 연용후 3개월후에 Estrogen 소퇴출혈을 일으킨 직후 소량의 Stilbestrol (총량 5만단위)로서 배란을 유발시키었으며 제2예는 Estrogen (총량 90mg) 연용한후 2개월휴지후 다시 대량 Estrogen (총량 90mg) 사용하였다. 그후 월경이 발래한 후 즉시, 비교적 소량 Estrogen(15mg)을 사용하여 배란을 야기시키었다. 2) 이 2예의 배란유발기전은 Estrogen의 중추작용이며 소위 Rebound 현상으로 인한것으로 본다.

1) Unovulatory sex cycle in the cases of oligomenorrhea and occasional oligomenorrhea was seen.First case was provoked the ovulation by estrogen withdrawal bleeding with large dose of estrogen (90mgm) during 3 months and small dose of stilbesterol immediaely after withdrawal bleeding.Second case was seen withdrawal bleeding by initial large dose and after 2 months vacation again large dose of estrogen.Thereafter this case was provoked the ovulation by small dose of estrogen immediately after the bleeding.2) The cases mentioned above might be provoked.The ovulation by the mechanism of control action of estrogen. Therefore, it was felt that this action was due to rebound reaction