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SCIE SCOPUS
kLight chain disease 에 대한 Fanconi`s syndrome 에서 골연화증과 사구체 족세포의 족돌기 소실을 보인 1 예
A Case of Adult Fanconi`s Syndrome with Glomerular Podocyte Foot Process Effacement and osteomalacia Induced by kLight Chain Disease
남재현(Jae Hyun Nam),최규헌(Gyu Hyun Choi),박기현(Ki Hyun Park),안철우(Chul Woo Ahn),송영득(Young Duk Song),임승길(Sung Kil Lim),이현철(Hyun Chul Lee),허갑범(Kap Bum Huh)
UCI I410-ECN-0102-2009-510-005279099
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The Fanconi`s syndrome is characterized by generalized disturbance of proximal tubular function. It leads to excessive losses of amino acids, glucose, phosphate, bicarbonate, and other substrates handled by the proximal tubules. The metabolic consequences are acidosis, hypophosphatemia, hypocalcemia, osteomalacia, osteoporosis, and growth retardation. Adult Fanconi`s syndrome is mostly secondary form caused by multiple myeloma, primary amyloidosis, light chain nephropathy, and heavy metal poisoning. We experienced 50-year-old woman with r light chain disease whose chief complaints were weakness of both lower extremities and multiple bone pain. This patient had renal glycosuria, hypercalciuria, normal anion gap type metabolic acidosis, osteomalacia and normal distal tubule acidification. Her bone marrow biopsy showed inappropriate proliferation of plasma cell. The patient underwent percutaneous renal biopsy in which was exceptionally observed focal effacement of podocyte foot process. So we report a case of osteomalacia caused by adult Fanconi`s syndrome and foot process effacement by κ-light chain disease (J Kor Soc Endocrinol 15:627-633, 2000).

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