A 41-year-old farmers wife was evsluated about her ssthma and rhinitis of five-year duration. She snd her husband had bred 20 to 30 cows since five years prior to occurrence of asthna. She showed a strong positive skin prick test reaction to snimal hair allergens from goat (3+) and deer(>5+) as well aa to cow hsir allergen(>5+)(1mg/ml) prepared with cow hair which they brought. Bronchoprovoaation test showed early asthmatic responses to both cow and deer hair extracts. Serum specific IgE sntibodies to cow and deer hair extracts were detected by enzyme-linked immuoaaorbent assay (ELISA). Cross ELISA inhibition study revealed a complete inhibition of deer hair specific IgE sntibody by cow hair allergen and a partial inhibition of cow hair specific IgE was noted by deer hair allergen. In conclusion, cow hair can cause occupational rhinitis and asthms in an exposed patient and cross-allergenicity between cow and deer hair allergen was noted.