The deficiency of estrogen for the young women brings bone loss and the fracture by osteoporosis is also reported from them. Especially different from spontaneous menopause, the velocity of decrease in bone mineral density is fast and bone loss is also caused in trabecular bone and cortical bone. We not only measured bone mineral density but also serum ostecalcin, PICP of bone formation marker and serum ICTP of bone resorption marker to know the interrelation between bone mineral density and bone turnover rate by researehing 108 amenorrheic patients. There is a significant negative correlation between bone mineral density(Z-score) of spine(n=73, r=-0.39, p<0.01) and femur neck(n=72, r=-0.41, p<0.01) and osteocalcin, significant correlation between BMD of spine(n=73, r--0.44, p<0.001) and femur neck (n=72, r=-0.45, p<0.001) and ICTP and negative correlation between BMD of spine(n=80, r=-0.37, p<0.001) and femur neck(n=80, r=-0.44, p<0.001) and PICP. Ionized calcium in blood and urine have little or no comelation for BMD(n=87, r-0.31, p<0.01). There is a significant positive correlation with ICTP(n=108, r=0.57, p<0.001) and PICP(n=108, r=0.56, p<0.05) for osteocalcin in serum In view of the results so far achieved,serum osteocalcin, ICTP, and PICP Mect a very significant state of BMD loss, and showed a increased rate of bone tumover in most of these patients.