The oxidative dehydrogenation of propane was studied using mixed catalsts of molybdeum, vanadium, and Niobium. Catalytic activities of oxidative dehyerogenation was improved by adding vanadium at constant Mo/Nb ratio. Mo_1V_(0.4)Nb_(0.2) showed highest activity with good selectivity. This catalyst has low crystalinity and has relatively small amount of activity oxygen in reation temperature.