3.135.222.112
3.135.222.112
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생체분해성 Poly ( DL - lactide - co - glycolide ) 랜덤공중합체 Micelle 에서 약물방출 (Ⅱ)
Release of Clonazepam from Biodegradable Poly ( DL - lactide - co - glycolide ) Random Copolymer Micelles (Ⅱ)
이동병 , 차월석 , 박영훈 , 김명렬 , 나재운 , 김종균 ( Dong Byung Lee , Wol Suk Cha , Yung Hoon Park , Myung Yul Kim , Jae Woon Nah , Chong Kyun Kim )
UCI I410-ECN-0102-2009-570-007301667
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The lineary release time according to the kinds of micelles prepared in the ratio 20:20 of DL-PLGA(70:30, 80:20, 90:10) and clonazepam was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLGA (90:10). Amount of drug release according to the kinds of micelles was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLEA (90:10). Homopolymers were not suited for drug carriers because drug release of poly DL-lactide was too delayed and poly glycolide shows the burst effect in early days.

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