새로운 항진균제를 합성하기 위하여 cis-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenol]piperazine(15)과 N-cycloalkylcarbamoyl 유도체인 N-cyclopropyl-2-chloroacetamide와 N-cyclohexyl-2-chloroacetamide를 반응시켜 치환기인(R=cyclopropyl, cyclohexyl)기가 도입된 2개의 새로운 유도체인 cis-1-(N-cycloalkyl substituted carbamoyl)-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine을 합성하였다.

In an effort of the synthesis of new antifungal agent, two new cis-1-(N-cycloalkyl substituted carbamoyl)-4[4-[[2-(2,4-dichlorophenyl)-2-(1-H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine derivatives(R=cyclopropyl, cyclohexyl) were synthesized by the reaction of cis-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine with N-cycloalkylcarbamoyl substituted derivatives.