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Chitosan - g - Poly ( 4- vinyl pyridine ) 공중합체막을 통한 인슐린의 투과 특성
Permeation Properties of Insulin through Chitosan - g - Poly ( 4- vinyl pyridine ) Membrane
김공수 , 강석호 , 김수종 , 임정규 ( Kong Soo Kim , Seog Ho Kang , Soo Jong Kim , Jeong Kyu Lim )
공업화학 vol. 5 iss. 4 624-629(6pages)
UCI I410-ECN-0102-2009-570-007313745

Chitosan-g-Poly(4-vinyl pyridine)공중합체막을 제조하였으며 Chitosan-g-Poly(4-vinyl pyridine)공중합체막과 아크릴아마이드를 사용하여 glucose oxidase를 포함하는 chitosan/acrylamide 복합막을 제조하였다. Chitosan-g-poly(4-vinyl pyridine)공중합체막의 함수율과 인슐린의 투과량은 용액의 pH가 감소함에 따라 증가하였고, 복합막의 인슐린 투과량은 글루코오스의 농도가 증가할수록 증가하였다.

Chitosan-g-poly(4-vinyl pyridine)membranes were prepared by crosslinking reaction using glutaraldehyde and glucose oxidase immobilized chitosan/acrylamide composite membranes were fabricated by chitosan-g-poly(4-vinyl pyridine) copolymer and acrylamide. Water content and permeability of insulin through chitosan-g-poly(4-vinyl pyridine)membranes increased with decreasing the pH of the medium Permeability of insulin through chitosan/acrylamide composite membranes increased with increasing the concentration of glucose.

[자료제공 : 네이버학술정보]
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