(2-(2, 6-디클로로페닐)아미노)페닐 아세트산나트륨의 합성단계를 줄이고 각 단계별 합성수율을 향상시켰다. 합성은 4단계로 하였으며 출발물질은 2, 6-디클로로아닐린과 모노브로모벤젠을 사용하였다. 첫단계인 Ullmann반응은 구리촉매를 3회 분할 첨가하여 80％의 수율로 진행시켰고, 아실화와 프리델-크라프트 반응도 효율적으로 단순화하였다. 최종 반응생성물인 디클로페낙은 클라이젠 용액을 사용하여 제3단계에서 얻은 1-(2, 6-디클로로페닐)-2-인돌리논을 가수 분해함으로써 97％의 수율로 얻었다.

The synthetic steps of sodium(2-(2, 6-dichlorophenyl) amino)phenylacetate were reduced and increased the yield in each steps. The synthetic process was composed to four steps and 2, 6-dichloroaniline and monobromobenzene were used as starting materials. The first step, Ullmann reaction was carried out by addition of copper catalyst in three lots in 80％ yield. The steps of acylation and Friedel-Craft reaction were simplified successfully. The final product, diclofenac was obtained in 97％ yield by hydrolyzing 1-(2, 6-dichlorophenyl)-2-indolinone which was gained in third step with Claisen-solution.