시판되고 있는 4종류의 Lipase(talpase, paratase M1000L, SP398, SP435)를 이용하여, 2-[1-(1-acetoxy-2,2, 2-trifluoroethyl)]-5-trimethylsilylfuran(1)을 속도론적 광학분할에 의해서 가수분해반응을 검토했다. 그 결과 Novo Nordish사의 SP435가 속도론적 광학분할능을 가진다는 것을 확인했으며, 본 실험에서는 광학순도 92.4% enantiomeric excess(ee)를 가지는 생성물 2-[1-(2,2,2-trifluoro-1-hydroxyethyl)]-5-trimethylsilylfuran(2)를 얻었다.

The hydrolysis of biochemical kinetic resolutions for 2-[1-(acetoxy-2, 2, 2-trifluoroethyl)] -5-trimethylsilylfuran(1) using four kinds of Lipase(talpase, paratase M1000L, SP398, SP435) was investigated. In the results, SP435 of Novo Nordish comp any was confirmed to show the capacity of biochemical kinetic resolutions, and 2-[1-(2, 2, 2-trifluoro-1-hydroxyethyl)]-5-trimethylsilylfuran(2) to have the optical purity expressed as 92.4% enantiomeric excess(ee) was produced in this studies.