1, 2-Dithiolane 기를 갖는 lipid 를 합성하여 vesicle 을 형성시킨 다음 이것을 ring opening polymerization 하여 고분자화된 vesicle을 합성하였다. 중합반응의 반응속도를 UV를 이용하여 측정한 결과, 반응속도가 1차반응 속도식을 만족하였으며 반응속도 상수값은 3.84×10^(-2)min^(-1)이었다. 또한 sucrose를 이용한 투과도 실험에서 고분자화된 vesicle의 투과도는 4.7×10^(-8)㎝ hr^(-1)이었으며 이 값은 고분자화되지 않은 경우보다 1.5배 낮은 것이다.

A lipid containing a 1, 2-dithiolane group was synthesized, and polymerized vesicle was prepared from the vesicle of this lipid by ring-opening polymerization. Reaction rate of the polymerization was monitored by UV absorption, and the results showed that it followed the first order kinetics and the rate constant 3.84×10^(-2) min^(-1). Permeation rate of sucrose through the polymerized vesicle was 4.7×10^(-8)㎝ hr^(-1), which is 1.5 times lower than that of monomeric analog.