This study was investigated the effects of a direct current and ultrasound on transdermal transport of dexamethasone into the rabbits which had contusion in the thigh. Each group was treated under the following conditions. 1. EXP group I : 10% dexamethasone ointment and ultrasound 2. EXP group II : 1% aqueous solution of dexamethasone and iontophoresis 3. EXP group III : the application of 10% dexamethasone ointment 4. Control group : No treatment The degree of anti-inflammation was evaluated by the naked eye, the change in girth of thigh, and a light microscope. The results were as follows. 1. By the naked eye, an inflammation sign was seen in all groups and especially, symptoms of redness, heat, swelling were prominent in EXP group I . 2. In comparision in the change of girth of thigh, only EXP group II showed no significant change. Therefore, it meant that there was effective anti-inflammatory reaction in EXP group II. 3. The infiltration of inflammation cells, the degree of swelling, and the degree of crosslinking of connective tissues were evaluated with a light microscope. As a result, EXP group II showed the most effective antiinflammatory reaction. And, in order of EXP group III, control group, the effect of anti-inflammation reaction was decreased. 4. EXP group I showed more intensive inflammation than control group.