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SCIE SCOPUS
Analysis of Role of the D - raf in the UV - Mediated Signal Transduction Pathway
( Hye Yeong Ha , Mi Ae Yoo )
UCI I410-ECN-0102-2009-470-007057907
This article is 4 pages or less.

Raf-1 kinase, a cytoplasmic Ser/Thr protein kinase, is activated upon treatment of cells with a variety of growth-stimulating agents, including ultraviolet light(UV) in animal cells. Drosophila homologue of c-raf-1, D-raf revealed multiple functions in regulation of cellular differentiation and proliferation during the development. In this study, we investigate function of the D-raf gene in UV-responsive events by using hypomorphic mutant D-raf^(C110) and D-raf-lacZ transgenic flies. Survivals of wild-type and D-raf^(C110) after UV irradiation were examined. Expression of the D-raf gene after UV-irradiation was examined by quantitative analysis and histochemical X-gal staining for β-galactosidase (β-gal) activity. Expression of the D-raf gene increased after UV-irradiation, showing the highest induction at 16 hr after UV-irradiation.

[자료제공 : 네이버학술정보]
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