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18.97.14.90
18.97.14.90
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SCIE SCOPUS
Structure and Expression , of Murine Poly ( A ) Binding Protein Ⅱ Gene
( Young Jae Lee , Jae Hyouk Lee , In Chul Yang , Yoon Soo Hahn , Young Hoon Lee , Jae Hoon Chung )
UCI I410-ECN-0102-2009-470-007057801
This article is 4 pages or less.

A genomic DNA clone and cDNA clones encoding murine poly(A) binding protein II (mPAB II), a component of the mammalian 3′-end processing machinery, were isolated in this study. The overall structure of mPAB II consists of an acidic N-terminal domain, an RNA-binding domain in the middle, and a basic C-terminal domain. Genomic structure of the mPAB II gene including the exon-intron arrangement shows significant homology with that of bovine PAB II. Southern blot analysis shows that the mPAB II gene has pseudogenes or related genes in mouse genome. Two mPAB II transcripts, 3.6 kb and 2.1 kb, are present in all tissues. An additional 1.4 kb transcript which is generated by differential polyadenylation is most abundantly produced in a testis-specific manner. The excessive exprssion of the mPAB II gene in testis, particularly in round spermatids, is related to the synthesis and the accumulation of all the mRNAs necessary for spermiogenesis.

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