The human genome contains a great number of DNA segments of variable number of tandem repeats (VNTR) loci. The VNTR locus detected by probe YNZ22 (D17S5) on chromosome 17q13.3 is considered to be a highly useful genetic marker. In the present study, genetic variation for the YNZ22 locus were analyzed in 161 unrelated Koreans using the PCR method. We observed 14 alleles and 55 phenotypes from this study. The distribution of phenotypes was significantly deviated from Hardy-Weinberg equilibrium (X²=23.683, df=10, 0.005