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SCIE SCOPUS
Production of the Anti - HLA Moncolonal Antibody Using Human Hybrid Myeloma
( Jee Young Ahn , Hye Joung Lee , Kwang Min Lee , Dong Sang Suh )
UCI I410-ECN-0102-2009-470-007057265
This article is 4 pages or less.

During transplant operation, we need specific antibodies against HLA antigens for the HLA typing between donor and recipient. On the production of the anti-HLA monoclonal antibody in the human system, up to this point available partner cell was not developed. We must develop more available fusion partner cell, therefore we fused SKO-007, human myeloma, and HeLa cell, human cervix carcinoma. We made more effective clones as human fusion partner cells. As a result, their doubling time is shorter than SKO-007 and they are 6-thioguanine resistant. The most available clone, HS-7, of them has the shortest doubling time, 35 hours, and its chromosome number is 70. It has been using for the production of the anti-HLA monoclonal antibody secreting hybridoma. It can be used as fusion partner cell for production of several monoclonal antibodies.

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