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SCIE SCOPUS
한국인 집단의 hTPO 좌위 초변이성의 유전적 특성
Genetic Characterization of hTPO VNTR Loci in Korean Population
이하규 , 신혜원 ( Ha Kyu Lee , Hye Won Shin )
UCI I410-ECN-0102-2009-470-007056713

VNTR(variable number tandem repeat) loci in the genome are characterized as their copy number of the same repeat unit and are extremely polymorphic having potentially hundreds of alleles at a single locus. In this study, allele distribution on the hTPO VNTR marker was analyzed by PCR (polymerase chain reaction) in Korean population (100 individuals). Twenty two alleles were identified in the hTPO VNTR locus and alleles 7 (8.5%), 10 (11.0%), and 15 (15.0%) showed three highest peaks. The allele frequency of hTPO VNTR locus is in the 95% confidence interval. PIC (polymorphism information content) value calculated on hTPO VNTR loci was 0.92. POE (power of exclusion) value used in paternity cases was 0.80. MP (matching probability) used in forensic identification was 0.018. In conclusion, statistical data from hTPO VNTR locus showed this locus is a very useful genetic marker for the linkage-study, evolutionary genetics and forensic application.

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