18.97.14.90
18.97.14.90
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SCIE SCOPUS
한국인 집단에서 11번 염색체상의 anonymous hypervariable 좌위에 대한 대립유전자의 분포
Allele Distribution of Anonymous Hypervariable Locus on Chromosome 11 in Korean Population
채재진 , 홍성수 , 김언경 , 고성호 , 김유섭 , 남궁용 ,이정주 ( Jae Jin Chae , Sung Soo Hong , Un Kyung Kim , Sung Ho Goh , Yu Seob Kim , Yong Namkoong , Chung Choo Lee )
UCI I410-ECN-0102-2009-470-007055665

To investigate the genetic characteristic of Korean population, anonymous hypervariable or VNTR locus on chromosome 11 was analyzed and we determined its allele distribution, informativeness and suitability for DNA typing. Anonymous VNTR locus based on the allelic variation of a 31-bp tandem repeat was analyzed in 114 unrelated samples (Seoul) by using the probe2.1 as a probe. The result showed that PsiI identifies multi-allele ranging in size from 2kb to 21kb with heterozygosity (H) of 0.973. For more conservative estimation of allele frequency distribution, arbitrary bin method was applied to this VNTR locus. The number of alleles of this locus observed in Korean to this VNTR locus. The number of alleles of this locus observed in Korean population was higher than that of Caucasians. The genotypic data and test of Hardy-Weinberg equilibrium (HWE) for the anonymous VNTR locus, proposed as a parameter of population homogeneity, revealed a slightly high level of H and slight deviation from HWE of the Koreans relative to Caucasians. Also, from populational data for this VNTR locus, statistical weight was offered for the application in DNA typing field.

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