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18.97.14.89
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SCIE SCOPUS
태반형 알칼라인 포스파타아제 유전형에 대한 단일클론 항체
Monoclonal Antibodies Against Common Phenotypes of Human Placental Alkaline Phosphatase
강희갑 , 윤종희 , 방옥순 , 이영섭 , 강신성 ( Hee Kap Kang , Jong Hee Yoon , Ok Sun Bang , Young Sup Lee , Shin Sung Kang )
Genes & Genomics vol. 15 iss. 4 345-354(10pages)
UCI I410-ECN-0102-2009-470-007055529

A total of nine monoclonal antibodies (MAbs) against common phenotypes of human placental alkaline phosphatase (PLAP) was produced by hybridoma using a mixture of PLAP subtypes (type 1+2+3) as antigen. Six of these reacted only with PLAP, but not with intestinal and liver alkaline phosphatases. Three out of these six MAbs have been found to discriminate at least one of the produce of three common alleles from others, while the other three MAbs reacted with the six common allelic varients. The results suggest that anti-PLAP MAbs can be used as probes to discriminate among allelic varients of PLAP.

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