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SCIE SCOPUS
사람 림프구에서 BLEOMYCIN 및 MITOMYCIN - C 에 의한 적응 반응
Adaptive Response in Human Lymphocytes by Bleomycin and Mitomycin - C
정해원 , 김양지 ( Hai Won Chung , Yang Jee Kim )
Genes & Genomics 14권 3호 161-172(12pages)
UCI I410-ECN-0102-2009-470-007055150

Human peripheral blood lymphocytes pre-exposed to low dose of Bleomycin which can induce double strand breaks in DNA, became less susceptible to the induction of chromatid breaks by high dose of same agent or by Mitomycin C which can induce cross-links in DNA, than those which were not pre-exposed to Bleomycin. But although lymphocytes adapted to Mitomycin C showed resistance to high concentration of the same agent, they did not show cross resistance to high concentration of Bleomycin. These results indicate that there might be different repair mechanisms in the adaptive response induced by different DNA damaging agents.

[자료제공 : 네이버학술정보]
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