효율적으로 국소마취를 유발시키는 procaine 이온도입의 효과적인 농도를 조사하였다. 19세에서 34까지의 자원자 45명을 9명씩 무작위로 5군으로 나누어 배치하고, 각군 대상자의 오른쪽 전완 전면에 각각 2% (pH 5.28), 4% (pH 5.12), 8% (pH 4.98), 16% (pH 4.72), 32% (pH 4.52)의 염산 procaine용액 2 ml을 적신 3.5×3.5 cm의 면패드를 대고 4 ㎃로 10분간 양극 직류전류를 통전시켰다. 이온도입 직후부터 5분 간격으로 21 G 주사침으로 이온도입부위를 1 ㎜함몰되게 눌러 바늘로 찌르는 통증을 느낄때까지 감각검사를 시행하여 국소마취지속시간을 측정하였다. Procaine의 농도에 따른 국소마취지속시간을 일원분산분석한 결과 유의한 차이를 보였으며 (F=5.83; df=4, 40; p$lt;.001), 이를 사후검정한 결과 농도 4%의 국소마취지속시간이 농도 2%, 8%, 16%, 32%보다 유의하게 길었다 (p$lt;.01). 또한 상관분석 결과 약물의 농도는 국소마취지속시간과 상관관계가 없었다 (r=-0.41,NS). 본 연구 결과 4% 농도의 염산 procaine 용액의 이온도입이 국소마취지속시간을 가장 길게 유지하여 4% 염산 procaine용액이 이온도입에 가장 효과적인 농도였음을 알 수 있었다.

The purpose of this study was to determine the effective concentlation of procaine iontophoresis for durarion of cutaneous local anesthesia. Forty-five healthy students with an age range of 19 to 34 years(21±2.7), were participated in this study, The subjects were randomly assigned into 5 groups. Each 9 subjects received iontophoresis on the flexor surface of dominant forearm with soft cotton pad (3.5×3.5 cm) soaked in 2 ml of 2% (pH 5.28), 4% (pH 5.12), 8% (pH 4.98), 16% (pH 4.72), 32% (pH 4.52) procaine hydrochloride solution at 4 ㎃ for 10 minutes (total current 40 ㎃·min) using anodal direct current. The study was performed in a randomized, double-blind design. After procaine iontophoresis, the duration of anesthesia were evaluated at five minute intervals on five random locations in the iontophoretically area using a 21-gauge sterile hypodermic needle pressed with 1 mm invagination until sharp pin-pricking pain sensation returned. The data were analyzed with one-way ANOVA to determine significant differences between groups. Duncan post hoc was performed at level .0l. The relationship between anesthetic duration and procaine concentration was assessed with Pearson Product-Moment Correlation Coefficients. ANOVA tests showed significant differences in the anesthetic duration between the concentration of procaine solution (p$lt;.001). Procaine iontophoresis with 4% concentration produced cutaneous local anesthesia of significantly longer duratlon(15.56 min) than iontophoress with 2%, 8%, 16%, and 32% of procaine HCI(p$lt;.01), Whereas the anesthetic duration had no correlation with concentration of procaine solution (r=-0.41, NS). These results support the 4% procaine solution was an effective concentration of iontophoresis for induced cutaneous local anesthesia.