Ti-6Al-4V alloy and Ti-6Al-2Sn-4Zr-2Mo/10TiB particulate composites were synthesized using a blended elemental powder metallurgy processing route. Microstructures and mechanical properties, such as tensile, creep, Young`s modulus and high-cycle fatigue-strength were evaluated. Special attention was paid to im­prove the high-cycle fatigue-strength of these two materials by modifying the matrix microstructure or pro­cess innovation. The fatiguecrackinitiation mechanism, relationship between α-phase morphology and high-cycle fatigue-strength, and other factors contributing to the increase in fatigue strength were analyzed.