The polyamines putrescine, spermidine, spennine are ubiquitous components of prokaryotic and eukaryotic cells. They appear to play important roles in cell proliferation and differentiation, and neoplasia. Their intracellular levels are regulated by a multitude of mechanisms. Some of these mechanisms are presently being unravelled by using monoclonal antibody, cDNA and genomic probes. The polyamine biosynthesis inhibitors have some potential as therapeutic agents against proliferative disorders and various parastic disease. A further understanding of polyarnine assist in the rational design related mechanisms will of new and more potent drugs for treatment of various disease affecting man.