About 20% of increased survival rate was found in chick embryo when L-carnosine was present, and it was demonstrated employing bioassay method that L-carnosine accelerated angiogenesis in fertilized egg. Experimental results from the studies of ³H-thymidine incorporation into bovine aorta endothlial cell in vitro indicated that L-carnosine greatly stimulated proliferation of the cell during the period of 48-and 72-hour culture. Taken together the results, it appears that L-carnosine acts as an angiogenesis factor in the process of would healing. Incorporation of ^(14)C-putrescine into cultured fibroblast reached plateau in 30 minutes and the incorporation was independent of L-carnosine concentration up to 10^(-2)%, L-Carnosine stimulated activity of membrane-bound transglutaminase during the period of 6-and 9-hour culture (39-50%) in trypsinized fibroblast.