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대한피부과학회> 대한피부과학회지> 저용량 전신스테로이드에 잘 반응한 얼굴에 발생한 Rosai-Dorfman Disease 1예

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저용량 전신스테로이드에 잘 반응한 얼굴에 발생한 Rosai-Dorfman Disease 1예

A Case of Cutaneous Rosai-Dorfman Disease on the Face Well Improved with Low-dose Systemic Corticosteroid

이상균 ( Sang Gyun Lee ) , 유대산 ( Dae San Yoo ) , 조미연 ( Mi Yeon Cho ) , 노미령 ( Mi Ryung Roh )
  • : 대한피부과학회
  • : 대한피부과학회지 58권6호
  • : 연속간행물
  • : 2020년 07월
  • : 428-430(3pages)

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  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2021
  • : 9479


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1한국 첩포 검사의 표준항원 양성률에 대한 분석 및 문헌고찰

저자 : 권보람 ( Boram Kwon ) , 이민영 ( Min Young Lee ) , 변지연 ( Ji Yeon Byun ) , 최유원 ( You Won Choi ) , 최혜영 ( Hae Young Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 371-381 (11 pages)

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Background: Korean standard series (KSS) have not changed for 20 years. Moreover, the Korea Food and Drug Administration has suspended import licensing of Cosmetic series (Chemotechnique).
Objective: To analyze trends in the positive rates of allergens in patch test using KSS and present a literature review on the comparison of the results those of European baseline series (EBS) and North American Contact Dermatitis Group (NACDG) screening series.
Methods: Epidemiologic findings and the positive rate of KSS allergens were analyzed from patients who visited the Department of Dermatology in Ewha Womans University Mokdong Hospital between 1998 and 2018. Literature reviews were conducted on the comparison of the results with those of the 2015∼2016 NACDG, 2013∼2014 ESSCA, and standard antigens in K-camp.
Results: The positive rates of KSS allergens from 126 patients in 2018 were compared with those from 184 patients during 1998 to 2007. The top 3 allergens in the two study periods were common; nickel sulfate, cobalt chloride, and potassium dichromate. Remarkably, the positive rates for balsam of Peru and paraben mix increased from 7.1% to 17.5% and from 2.7% to 7.9%, respectively. As compared with the results of NACDG standard series and EBS, KSS lacked fragrance and cosmetic series of allergens, especially fragrance mix II, methyldibromoglutaronitrile, and methylisothiazolinone, and epoxy series of allergens.
Conclusion: Our results, especially the increasing trends of balsam of Peru and paraben mix, would be further confirmed in a multicenter study. Additionally, in view of the increase in fragrance and preservative allergens, KSS would need the addition of related allergens. (Korean J Dermatol 2020;58(6):371∼381)

2여드름 환자에서 Adapalene-benzoyl Peroxide MLE (Multi Lamellar Emulsion) 고정용량 복합제제 요법의 치료 효과에 대한 연구

저자 : 박소희 ( So Hee Park ) , 박인호 ( In Ho Park ) , 황성환 ( Sung Hwan Hwang ) , 정소영 ( So Young Jung ) , 왕한영 ( Han Young Wang ) , 김효진 ( Hyojin Kim ) , 김종욱 ( Jong Uk Kim ) , 설정은 ( Jung Eun Seol )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 382-388 (7 pages)

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Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Adapalene-benzoyl peroxide gel has been proven to be effective in the treatment of both inflammatory and comedonal acne. However, skin irritation characterized by erythema, scaling, and dryness may occur with the use of this formula.
Objective: This study aimed to investigate the effects and safety of a new formulation of adpalene-benzoyl peroxide in combination with multi-lamellar emulsion (MLE) for acne treatment.
Methods: All patients were treated with adapalene-benzoyl peroxide with MLE once daily for 12 weeks on acne lesions. The subjects visited the hospital at baseline, 2 weeks, 4 weeks, 8 weeks, and 12 weeks, and clinical effects, patient satisfaction, and adverse effects were estimated. The severity of adverse effects was measured on a 4-point scale.
Results: A total of 30 subjects were enrolled. The number of lesions decreased significantly from 20.2 to 7.8 (p<0.0001) after treatment. Investigator's global assessment showed almost clear, and patient satisfaction increased from 3.57 to 4.13. The subjects had adverse effects such as tingling sensation (83.3%), scales (80.0%), erythema (63.3%), and dryness (63.3%). Severity of adverse effects had 1 point on average. Additionally, transepidermal water loss was found to be decreased.
Conclusion: This study suggests that adapalene-benzoyl peroxide with MLE is effective for treating acne lesions and shows high patient satisfaction. Hence, this new combination could be a safe and well-tolerated option for acne treatment. (Korean J Dermatol 2020;58(6):382∼388)

3중등증 및 중증의 한국인 건선 환자에서 Ixekizumab의 효과와 안전성에 관한 연구

저자 : 원상현 ( Sang-hyeon Won ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김문범 ( Moon-bum Kim ) , 김병수 ( Byung-soo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 389-396 (8 pages)

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Background: Ixekizumab is a humanized IgG4 monoclonal antibody that selectively binds to the IL-17A cytokine and inhibits its interaction with the IL-17 receptor. It has emerged as an effective treatment for moderate to severe psoriasis. However, to date, there are no real-world data for the use of ixekizumab in the treatment of psoriasis in Korean patients.
Objective: To evaluate the effectiveness and safety of ixekizumab in the treatment of moderate to severe psoriasis in Korean patients.
Methods: This was a retrospective single-center study. Thirty psoriasis patients who were treated with ixekizumab were analyzed. All patients' medical records, Psoriasis Area and Severity Index (PASI) score, body surface area (BSA), Physicians' Global Assessment (PGA), and adverse events were investigated.
Results: A significant reduction in mean (±standard deviation) baseline PASI score (14.1±2.6) was detected at 4 weeks of ixekizumab therapy (3.8±2.7, p<0.001), with a further improvement at weeks 12 and 24 (0.9±0.7 and 0.5±0.5, respectively) (p<0.001). Our analysis showed that 100%, 87.5%, and 50% of patients achieved PASI 75, 90, and 100 responses, respectively, after 48 weeks of therapy. However, nine patients (30%) experienced a mild adverse event such as injection site reaction, urticaria, upper respiratory tract infection, and stomatitis. No serious adverse events were observed.
Conclusion: This study provides evidence for the use of ixekizumab in real-world clinical practice and confirm that it is effective and safe in treating Korean patients with moderate to severe psoriasis. (Korean J Dermatol 2020;58(6):389∼396)

4원형탈모증 환자의 발병 연령별 임상 양상과 장기간의 추적을 통한 예후 연구

저자 : 조선영 ( Sun Young Jo ) , 고재완 ( Jae Wan Go ) , 허은필 ( Eun Phil Heo )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 397-405 (9 pages)

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Background: Alopecia areata is an autoimmune disease that presents as non-scarring hair loss and can affect all age groups. The clinical course of alopecia areata is unpredictable.
Objective: This study aimed to analyze the characteristics, treatment response, and relapse rate of alopecia areata in patients of different ages with long-term follow-up.
Methods: The medical records of 121 patients diagnosed with alopecia areata were retrospectively reviewed, and their prognosis was assessed on the basis of various indices.
Results: A total of 121 patients, including 24 cases of childhood-onset, 83 adult-onset, and 14 late-onset alopecia areata, were analyzed. In the first episode, 72.7%, 14.7%, and 9.9% of patients had mild, moderate, and severe alopecia areata, respectively. A significant and complete response was observed in 66.7%, 89.2%, and 100% of childhood-onset, adult-onset, and late-onset patients, respectively. The duration of the initial episode showed a negative correlation with age. The overall frequency of relapse was 47.1%, whichc significantly declined with time, with a majority (63.3%) of relapses occurring in the first year. Younger age at initial presentation and thyroid diseases were strongly associated with poor prognosis.
Conclusion: Younger patients showed a tendency of poor prognosis regardless of the prognostic factors. A longer follow-up period might be required for the younger onset patients. (Korean J Dermatol 2020;58(6):397∼405)

5영아에서 발생한 파종성 구진 양상의 B세포 가성림프종 1예

저자 : 서중헌 ( Joong Heon Suh ) , 김호영 ( Ho Young Kim ) , 이재호 ( Jae Ho Lee ) , 김중호 ( Joong Ho Kim ) , 이수경 ( Soo Kyung Lee ) , 이운하 ( Un Ha Lee ) , 김명신 ( Myoung Shin Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 406-410 (5 pages)

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Cutaneous pseudolymphoma is a heterogeneous group of benign reactive T- or B-cell lymphoproliferative diseases of the skin that simulate cutaneous lymphomas histologically and, sometimes, clinically. Thus far, only a few cases of pseudolymphomas showing atypical clinical manifestations have been reported. A 10-month-old boy presented with multiple flesh-colored, yellowish erythematous disseminated papules on the face, abdomen, and arms. The cutaneous lesions morphologically resembled molluscum contagiosum, Langerhans cell histiocytosis, or juvenile xanthogranuloma. Punch biopsy and immunohistochemistry studies were performed, and the lesion was identified as a cutaneous B-cell pseudolymphoma. Most of the lesions were cleared within a month with systemic corticosteroids and oral antihistamine administration. In this report, we present an interesting rare case of infantile cutaneous B-cell pseudolymphoma mimicking many other dermatological diseases in addition to a cutaneous lymphoma. (Korean J Dermatol 2020;58(6):406∼410)

6Diclofenac에 의한 다발성 고정약진 2예

저자 : 이호정 ( Ho Jung Lee ) , 홍정연 ( Jeong Yeon Hong ) , 박태흠 ( Tae Heum Park ) , 이성열 ( Sung Yul Lee ) , 이종석 ( Jong Suk Lee ) , 정의현 ( Euy Hyun Chung ) , 이상훈 ( Sang Hoon Lee ) , 김정은 ( Jung Eun Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 411-415 (5 pages)

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Fixed drug eruption (FDE) is a drug-induced disorder that may appear as patches or bullae. It recurs at the same sites as those involved in exposure to the same drug (causative drug). We encountered two cases of generalized FDE, and both patients had a history of diclofenac exposure before the onset of skin lesions. In the first case, an 82-year-old female patient presented with multiple erythematous patches on the trunk and lower extremities. In the second case, a 71-year-old male patient developed multiple bullae on violaceous patches on the trunk and extremities. The findings of histopathologic examinations were indicative of the diagnosis of FDEs. Although diclofenac is commonly used as a non-steroidal inflammatory drug, diclofenac-induced generalized FDE occurs rarely and has not been reported in Korea. With reuse of causative drugs, the size and number of lesions tend to increase. Therefore, early diagnosis of FDE is important, and avoidance of repeated exposure to drugs should be educated

7입술에 발생한 지방종 1예

저자 : 류재연 ( Jae Yeon Ryu ) , 박철종 ( Chul Jong Park ) , 이경호 ( Kyung Ho Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 416-418 (3 pages)

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Lipoma is a very common benign tumor of the adipose tissue, but it occurs infrequently in the oral cavity. A 66-year-old man presented with an asymptomatic, solitary, 1×1-cm-sized yellowish mass on the lower lip, since 2 years. For differential diagnosis, skin biopsy was performed, and histopathologic examination showed features indicative of lipoma. We herein report a rare case of oral lipoma occurring on the lower lip. (Korean J Dermatol 2020;58(6):416∼418)

8펀치 생검으로는 정확히 진단되지 않았으나 더모스코피를 통해 확진에 도움이 된 표재성 기저세포암 1예

저자 : 박태준 ( Tae Jun Park ) , 김고은 ( Ko Eun Kim ) , 정재영 ( Jae Young Jeong ) , 유화정 ( Hwa Jung Ryu ) , 손상욱 ( Sang Wook Son ) , 김일환 ( Il-hwan Kim ) , 문혜림 ( Hye Rim Moon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 419-422 (4 pages)

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Basal cell carcinoma is a common cancer and has been reported to account for approximately 80% of non-melanoma skin cancers. Superficial basal cell carcinoma occurs mainly in the trunk or limbs and is characterized by clinical features of scaly erythema with or without epidermal atrophy. These clinical features require differentiation from those of other benign and malignant skin diseases. Recently, specific dermoscopic findings of basal cell carcinoma have been helpful for diagnosis. Common dermoscopic findings of superficial basal cell carcinoma include superficial telangiectasia and maple leaf-like areas. Herein, we report a case of superficial basal cell carcinoma that was not diagnosed by punch biopsy but by dermoscopy. (Korean J Dermatol 2020;58(6):419∼422)

9혼합결합조직질환에서 발생한 '소금후추가루양상 (Salt and Pepper Appearance)'의 피부색소변화 1예

저자 : 원상현 ( Sang-hyeon Won ) , 신기혁 ( Kihyuk Shin ) , 김우일 ( Woo-il Kim ) , 양민영 ( Min-young Yang ) , 이원구 ( Won-ku Lee ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byung-soo Kim ) , 김문범 ( Moon-bum Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 423-426 (4 pages)

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The salt and pepper appearance of the skin is composed of salt (vitiligo-like depigmentation) and pepper (perifollicular pigmentation). Mixed connective tissue disease (MCTD) is a distinct disease entity with mixed features of systemic lupus erythematosus, systemic sclerosis, myositis, and rheumatoid arthritis with high titers of antibodies to U1 ribonucleoprotein (U1RNP). There are a few reports of pigmentary changes in MCTD. A 51-year-old woman presented with variably sized hypopigmented macules along with relative hyperpigmentation of the perifollicular areas on the face and neck; she was diagnosed with MCTD in a rheumatology clinic. Histopathology revealed dermal sclerosis in both hypo- and hyperpigmented areas, loss of melanocyte and pigment only in the hypopigmented area, and normal number of melanocyte and pigment in the hyperpigmented area. To the best of our knowledge, 'salt and pepper appearance of the skin' has rarely been reported in MCTD. (Korean J Dermatol 2020;58(6):423∼426)

10하지에 발생한 피부 스파르가눔증 1예

저자 : 고병창 ( Byeong Chang Ko ) , 박희재 ( Hee Jae Park ) , 오재홍 ( Jae Hong Oh ) , 함승필 ( Seung Pil Ham ) , 박혜진 ( Hai-jin Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 6호 발행 연도 : 2020 페이지 : pp. 427-428 (2 pages)

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대한피부과학회지
59권 1호 ~ 59권 1호

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대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 4호 ~ 46권 4호

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Annals of Dermatology
33권 1호 ~ 33권 1호

프로그램북(구 초록집)
72권 2호 ~ 72권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 10호 ~ 58권 10호

KCI등재 SCOUPUS

대한피부과학회지
58권 9호 ~ 58권 9호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 6호 ~ 32권 6호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 5호 ~ 32권 5호

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대한피부과학회지
58권 8호 ~ 58권 8호

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대한피부과학회지
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KCI등재 SCI SCOUPUS

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32권 4호 ~ 32권 4호

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대한피부과학회지
58권 6호 ~ 58권 6호

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46권 2호 ~ 46권 2호

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대한피부과학회지
58권 5호 ~ 58권 5호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

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대한피부과학회지
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