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대한천식알레르기학회(구 대한알레르기학회)> Allergy asthma & respiratory disease> 영아기에 실내 반려동물의 노출이 소아의 동물 항원 감작과 천식에 미치는 영향

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영아기에 실내 반려동물의 노출이 소아의 동물 항원 감작과 천식에 미치는 영향

Indoor pet ownership in infancy is a risk factor for the development of sensitization to pets and asthma in childhood

정성수 ( Sungsu Jung ) , 노수란 ( Soo Ran Noh ) , 이소연 ( So-yeon Lee ) , 윤지선 ( Jisun Yoon ) , 조현주 ( Hyun-ju Cho ) , 김영호 ( Young-ho Kim ) , 서동인 ( Dong In Suh ) , 양송이 ( Song-i Yang ) , 권지원 ( Ji-won Kwon ) , 장광천 ( Gwang Cheon Jang ) , 선용한 ( Yong Han Sun ) , 우성일 ( Sung-il Woo ) , 윤유숙 ( You-sook Youn ) , 박강서 ( Kang Seo Park ) , 이은 ( Eun Lee ) , 조화진 ( Hwa Jin Cho ) , 국명희 ( Myung-hee Kook ) , 이혜령 ( Hye Ryoung Yi ) , 정혜리 ( Hai Lee Chung ) , 김자형 ( Ja Hyeong Kim ) , 김형영 ( Hyung Young Kim ) , 정진아 ( Jin A Jung ) , 우향옥 ( Hyang-ok Woo ) , 홍수종 ( Soo-jong Hong )
  • : 대한천식알레르기학회(구 대한알레르기학회)
  • : Allergy asthma & respiratory disease 7권2호
  • : 연속간행물
  • : 2019년 04월
  • : 99-105(7pages)

DOI


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Purpose: It is controversial whether indoor pet exposure is either a risk or protective factor developing sensitization to pet allergens or asthma. Therefore, we investigated whether indoor pet ownership entails a risk for the development of asthma and sensitization in childhood.
Methods: The Panel Study of Korean Children (PSKC) is a general-population-based birth cohort study that recruited 2,078 mother-baby dyads in Korea between April and July of 2008. Among 1,577 children who were followed up in 2015, 559 underwent skin prick tests, spirometry and bronchial provocation tests using Provocholine. Having a cat or a dog and the prevalence of asthma were evaluated by using self-reported questionnaires and physicians’ medical records.
Results: During infancy, the rate of dog ownership was 4.5% (71 of 1,574) and that of cat ownership was 0.5% (8 of 1,574). Of the subjects, 7.9% (n=109) currently had at least 1 dog and 2.5% (n=34) had at least 1 cat. Pet ownership during infancy was associated with sensitization to cats or dogs (adjusted odds ratio [aOR], 4.24; 95% confidence interval [CI], 1.29-13.98), wheezing within 12 months (aOR, 5.56; 95% CI, 1.65-18.75) and current asthma (wheezing episode in the last 12 months+diagnosed asthma by physicians) (aOR, 6.36; 95% CI, 1.54-26.28). In contrast, pet ownership during the last 12 months was not associated with sensitization to cats or dogs or current asthma.
Conclusion: Indoor pet exposure during infancy can be critical for developing sensitization to cats or dogs and asthma in childhood. Avoidance of pet exposure in early life may reduce sensitization to cats or dogs and development of asthma. (Allergy Asthma Respir Dis 2019;7:99-105)

UCI(KEPA)

I410-ECN-0102-2019-500-001604884

간행물정보

  • : 의약학분야  > 내과학
  • : KCI등재
  • :
  • : 계간
  • : 2288-0402
  • : 2288-0410
  • : 학술지
  • : 연속간행물
  • : 2013-2020
  • : 492


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1국내 소아 크룹의 원인 바이러스

저자 : 김정희 ( Jeong Hee Kim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 65-66 (2 pages)

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2국내 알레르기 유발식품 표시제의 현황과 문제점

저자 : 전유훈 ( You Hoon Jeon ) , 김현희 ( Hyun Hee Kim ) , 박용민 ( Yong Mean Park ) , 장광천 ( Gwang Cheon Jang ) , 김혜영 ( Hye-young Kim ) , 염혜영 ( Hye Yung Yum ) , 김지현 ( Jihyun Kim ) , 안강모 ( Kangmo Ahn ) , 민택기 ( Taek Ki Min ) , 편복양 ( Bok Yang Pyun ) , 이수영 ( Sooyoung Lee ) ,

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 67-72 (6 pages)

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With increasing need to prevent serious food allergy reactions, Korean food allergen labeling regulation has been revised repeatedly. This paper aims to summarize current statuses of food allergen labeling in Korea and foreign countries and to analyze the issue of food allergen labeling regulation. Korean food labeling regulation currently requires 19 items and 22 foods to be reported on labels (eggs, milk, buckwheat, peanut, soybean, wheat, mackerel, crab, shrimp, pork, peach, tomato, sulfite, walnut, chicken, beef, squid, shellfish, and pine nut). However, some common food triggers (for example, almond, cashew nut, and kiwi fruit) are not included in the current labeling regulation. Another issue is that the Korean labeling regulation has not yet been fully implemented for nonprepacked foods; thus, consumers still have difficulty in correctly identifying allergenic ingredients in food. It should be assessed whether warning statements for cross-contamination are reasonable. To prevent the occurrence of serious reactions from accidental ingestion, efforts must be made to solve recently raised issues including the items required to be listed on food labels, the system of standards for labeling and display methods. (Allergy Asthma Respir Dis 2019;7:67-72)

3천식과 비만: 천식은 비만의 위험 요소인가?

저자 : 김자경 ( Ja Kyoung Kim ) , 양정희 ( Jeong Hee Yang )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 73-77 (5 pages)

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Many studies have shown that asthma and obesity are linked and affect each other. Although obesity is an important risk factor for asthma, it is controversial whether asthma is a risk factor for obesity vice versa. Recent United States and European cohort studies have published papers reporting that pediatric asthma is a risk factor for obesity in school-aged children or adolescents. Previous studies have shown inconsistent results, suggesting that the 2 diseases are highly complex and that the relationships between them are strong. In order to understand the relationships between the 2 diseases, it is necessary to approach them from a new point of view such as energy metabolism relevance or autonomic nervous system control. (Allergy Asthma Respir Dis 2019;7:73-77)

4소아 크룹 입원 환자의 병인과 계절적 변동: 6년간의 다기관 후향적 연구(2010-2015년)

저자 : 이용주 ( Yong Ju Lee ) , 김효빈 ( Hyo-bin Kim ) , 김봉성 ( Bong-seong Kim ) , 김창근 ( Chang-keun Kim ) , 김철홍 ( Cheol Hong Kim ) , 김형영 ( Hyung Young Kim ) , 김상영 ( Sangyoung Kim ) , 김윤선 ( Yunsun Kim ) , 박초롱 ( Chorong Park ) , 서주희 ( Ju-hee Seo ) , 설인숙 ( In Suk Sol ) , 성

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 78-85 (8 pages)

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Purpose: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of parainfluenza virus. However, seasonal and annual epidemics of croup have not been clearly reported in Korea. This study aimed to examine the seasonal/annual patterns and etiologies of childhood croup in Korea during a consecutive 6-year period.
Methods: Pediatric croup data were collected from 23 centers in Korea from 1 January 2010 to 31 December 2015. Electronic medical records, including multiplex reverse transcription polymerase chain reaction (RT-PCR) results, demographics and clinical information were cross-sectionally reviewed and analyzed.
Results: Overall, 2,598 childhood croup patients requiring hospitalization were identified during the study period. Among them, a total of 927 who underwent RT-PCR were included in the analysis. Males (61.5%) predominated, and most (63.0%) of them were younger than 2 years of age (median, 19 months; interquartile range, 11-31 months). Peak hospitalization occurred in 2010 and 2012 in even-numbered years, and parainfluenza virus (PIV, 39.7%) was the most common cause of childhood croup requiring hospitalization, followed by respiratory syncytial virus (14.9%), human rhinovirus (12.5%), Mycoplasma pneumonaie (10.6%), and human coronavirus (7.3%).
Conclusion: It is concluded that croup hospitalization has a biennial pattern in even-numbered years. PIV may be the most common cause of childhood croup; however, croup epidemics could be attributed to other viruses. (Allergy Asthma Respir Dis 2019;7:78-85)

5호흡기세포융합바이러스와 인플루엔자바이러스감염에서 단일 감염과 복합 감염의 임상 중증도 비교

저자 : 박진성 ( Jin-sung Park ) , 곡수옥 ( Shou-yu Chu ) , 신이연 ( Yi-yeon Shin ) , 유인경 ( In-kyung Ryu ) , 탕지륭 ( Chih-lung Tang ) , 최준기 ( Jungi Choi ) , 김효빈 ( Hyo-bin Kim ) , 김창근 ( Chang-keun Kim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 86-91 (6 pages)

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Purpose: Multiple virus infections may affect clinical severity. We investigated the effect of coinfection of respiratory syncytial virus (RSV) and influenza virus with other respiratory viruses on clinical severity.
Methods: Data from 634 samples of a single tertiary hospital between September 2014 and April 2015 were analyzed for clinical characteristics (fever duration and O2 need, steroid use, and ICU care) between single infection and coinfection of RSV (n=290) and influenza virus (n=74) with 16 common respiratory viruses from hospitalized children.
Results: The RSV coinfection group (n=109) (3.1±2.7 days) showed significantly longer fever duration than the RSV single infection group (n=181) (2.6±2.6 days) (P=0.04), while there was no difference in O2 need, steroid use or ICU care in the 2 groups. The influenza coinfection group (n=38) showed significantly higher O2 need than the influenza single infection group (n=36) (21.1% vs. 5.6%, P=0.05), while there was no difference in fever duration between the 2 groups.
Conclusion: The results indicate that RSV and Influenza coinfections can increase clinical severity and that the severity may be influenced by the nature of coinfecting viruses. (Allergy Asthma Respir Dis 2019;7:86-91)

6소아 천식 조절 지표로서의 기관지확장제반응의 유용성

저자 : 김종덕 ( Jong Deok Kim ) , 김수연 ( Soo Yeon Kim ) , 김윤희 ( Yoon Hee Kim ) , 김경원 ( Kyung Won Kim ) , 손명현 ( Myung Hyun Sohn ) , 설인숙 ( In Suk Sol )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 92-98 (7 pages)

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Purpose: Assessing asthma control is important for proper management, and various indices for objective assessment of asthma control, such as fractional exhaled nitric oxide (FeNO) and asthma control test (ACT) score have been proposed. Recently, bronchodilator response (BDR) was reported as a marker of poor asthma control in adults. This study aimed to assess the usefulness of BDR as a biomarker for childhood asthma.
Methods: A total of 305 children diagnosed with asthma were included. Spirometry with bronchodilator test was done at the time of diagnosis and about 14 months after asthma treatment. All children were evaluated by childhood asthma control test (c-ACT) and FeNO after asthma treatment. The patients were divided into 2 groups according to BDR results: the positive and negative BDR groups. Various biomarkers for asthma control, such as c-ACT, FeNO and changes of forced expiratory volume in 1 second (FEV1), were compared between the 2 groups.
Results: Of the 305 patients, 143 (46.9%) were positive and 162 (53.1%) were negative for BDR. The BDR-positive group showed lower FEV1. In the BDR positive group, FEV1 was significantly increased after asthma treatment, especially in children with airflow limitation which was defined as below 80% of FEV1 or atopy. In atopic children, BDR showed a significant negative correlation with c-ACT and a positive correlation with FeNO.
Conclusion: In asthmatic children with airflow limitation at the time of diagnosis, BDR can be a useful index for predicting improvement in lung function by asthma maintenance treatment. BDR could be a reliable marker for the assessment of asthma control in atopic children. (Allergy Asthma Respir Dis 2019;7:92-98)

7영아기에 실내 반려동물의 노출이 소아의 동물 항원 감작과 천식에 미치는 영향

저자 : 정성수 ( Sungsu Jung ) , 노수란 ( Soo Ran Noh ) , 이소연 ( So-yeon Lee ) , 윤지선 ( Jisun Yoon ) , 조현주 ( Hyun-ju Cho ) , 김영호 ( Young-ho Kim ) , 서동인 ( Dong In Suh ) , 양송이 ( Song-i Yang ) , 권지원 ( Ji-won Kwon ) , 장광천 ( Gwang Cheon Jang ) , 선용한 ( Yong Han Sun ) , 우성일 ( Su

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 99-105 (7 pages)

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Purpose: It is controversial whether indoor pet exposure is either a risk or protective factor developing sensitization to pet allergens or asthma. Therefore, we investigated whether indoor pet ownership entails a risk for the development of asthma and sensitization in childhood.
Methods: The Panel Study of Korean Children (PSKC) is a general-population-based birth cohort study that recruited 2,078 mother-baby dyads in Korea between April and July of 2008. Among 1,577 children who were followed up in 2015, 559 underwent skin prick tests, spirometry and bronchial provocation tests using Provocholine. Having a cat or a dog and the prevalence of asthma were evaluated by using self-reported questionnaires and physicians' medical records.
Results: During infancy, the rate of dog ownership was 4.5% (71 of 1,574) and that of cat ownership was 0.5% (8 of 1,574). Of the subjects, 7.9% (n=109) currently had at least 1 dog and 2.5% (n=34) had at least 1 cat. Pet ownership during infancy was associated with sensitization to cats or dogs (adjusted odds ratio [aOR], 4.24; 95% confidence interval [CI], 1.29-13.98), wheezing within 12 months (aOR, 5.56; 95% CI, 1.65-18.75) and current asthma (wheezing episode in the last 12 months+diagnosed asthma by physicians) (aOR, 6.36; 95% CI, 1.54-26.28). In contrast, pet ownership during the last 12 months was not associated with sensitization to cats or dogs or current asthma.
Conclusion: Indoor pet exposure during infancy can be critical for developing sensitization to cats or dogs and asthma in childhood. Avoidance of pet exposure in early life may reduce sensitization to cats or dogs and development of asthma. (Allergy Asthma Respir Dis 2019;7:99-105)

8Nizatidine (histamine H2 receptor antagonist)에 의해 유발된 즉시형 과민반응 1예

저자 : 박승우 ( Seung-woo Park ) , 허연정 ( Yeon-jeong Heo ) , 이규선 ( Kyu-sun Lee ) , 권재우 ( Jae-woo Kwon )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 106-108 (3 pages)

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Nizatidine is a histamine H2 receptor antagonist that inhibits stomach acid production and is commonly used in the treatment of peptic ulcer and gastroesophageal reflux. H2 receptor antagonists are typically well tolerated, and hypersensitivity reactions are rare. A 19-year-old woman developed urticaria 30 minutes after taking a drug containing nizatidine. Allergic reactions to nizatidine were confirmed via skin prick test, which also revealed cross-reactions to ranitidine. We believe that this is the first case report on immediate hypersensitivity to nizatidine in Korea. (Allergy Asthma Respir Dis 2019;7:106-108)

9Rituximab 지연성과민반응에 대한 신속 탈감작 적용 1예

저자 : 이수호 ( Su Ho Lee ) , 이재하 ( Jae Ha Lee ) , 김남희 ( Nam Hee Kim ) , 강동윤 ( Dong Yoon Kang ) , 이주연 ( Ju Yeun Lee ) , 정수지 ( Soo Jie Chung ) , 오지현 ( Ji Hyun Oh ) , 강혜련 ( Hye-ryun Kang )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 7권 2호 발행 연도 : 2019 페이지 : pp. 109-112 (4 pages)

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Rituximab is a monoclonal antibody used for the treatment of B-cell malignancies, including diffuse large B-cell lymphoma. Infusion-related hypersensitivity reactions to rituximab is well known, and delayed hypersensitivity reactions to rituximab are also reported. Desensitization is commonly used to prevent immediate hypersensitivity reactions, but recently there have been cases of successful desensitization therapy for delayed hypersensitivity reactions. A 66-year-old patient who underwent rituximab treatment for diffuse large B-cell lymphoma showed repeated rituximab-induced delayed hypersensitivity reactions with whole body rashes. Intravenous rapid desensitization was performed by using a 1-bottle, 11-step protocol for 6 cycles and thereafter hypersensitivity reaction did not recur. We herein reported a case of delayed hypersensitivity reaction caused by rituximab, which was successfully desensitized using our 11-step protocol. (Allergy Asthma Respir Dis 2019;7:109-112)

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