Objectives: This study was to investigate effects of family- resilience on post-traumatic growth(PTG) of a childhood cancer patient's mothers and to examine the double-mediating effects of the meaning of life and active stress coping strategy. Method: The self-report questionnaires were administered to 113 mothers of children with cancer. For data processing, SPSS 25.0 was utilized to estimate frequency, percentage, mean, standard deviation reliability coefficient(Cronbach's α), and t-test, in addition, one-way ANOVA, Pearson's correlation, Scheff's test, Hierarchical regression analysis, Bootstrap analysis were performed. Results: There were significant correlations among variables discussed above. Post-traumatic growth (PTG) had a significant correlation with family-resilience, the meaning of life and active stress coping strategy. It has been confirmed that family-resilience of childhood cancer patient's mothers affects post-traumatic growth(PTG) by double-mediating the meaning of life and active stress coping strategy. Conclusions: It suggests that family-resilience plays a significant role for mothers with childhood cancer to improve post-traumatic growth(PTG). The results of the study can be used as the basic data for development of the consultation and education program to help post-traumatic growth(PTG) of childhood cancer patient's mothers. This study also provides meaningful insights to improve post-traumatic growth of childhood cancer patient's mothers in medical institutions.