Background: Laser lipolysis is a recently accepted treatment modality for the removal of unwanted fat tissue with shorter down time and fewer sequelae. Although a variety of wavelengths have been introduced to improve clinical outcome, a 1,927 nm laser that shows greater fat and water absorption than previous wavelengths such as 1,440 nm was not attempted before. Objectives: To evaluate the clinical efficacy and safety of the novel 1,927 nm diode laser (Xlender^®, Wontech Corporation, Daejon, South Korea) in laser lipolysis of the lower abdomen Methods: Total 20 participants underwent one or two treatment session(s) on a 10x10 cm² of each right and left lower abdomen. Laser irradiation was only taken place on the right side and the other procedures were completely same. Clinical photographs, abdominal circumference and skin elasticity were obtained at baseline and at 12 and 24 weeks after treatment cessation. Results: Most patients showed significant clinical improvement. The abdominal circumference and skin elasticity in the treatment area revealed significant change and patients described satisfactory results. The right side showed better results compared to left side. There was no observed serious adverse event. Conclusion: The 1,927 nm diode laser is one of the effective and safe methods for laser lipolysis of the lower abdomen. Further studies with more patients and comparison with other devices are warranted to verify our results.