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대한피부과학회> 대한피부과학회지> 원저 : 대상포진 통증에 대한 Botulinum Toxin A의 효과

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원저 : 대상포진 통증에 대한 Botulinum Toxin A의 효과

Original Article : Effect of Botulinum Toxin A on Acute and Chronic Pain in Herpes Zoster Patients

한길 ( Gil Han ) , 김수현 ( Soo Hyun Kim ) , 이규석 ( Kyu Suk Lee ) , 조재위 ( Jae We Cho )
  • : 대한피부과학회
  • : 대한피부과학회지 52권12호
  • : 연속간행물
  • : 2014년 12월
  • : 845-850(6pages)
피인용수 : 13건

(자료제공: 네이버학술정보)

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Background: Many strategies are currently used to reduce herpes zoster pain, such as opioid analgesic administration and transcutaneous electrical nerve stimulation. However, a more effective and convenient method to reduce herpes zoster pain is needed. Objective: The purpose of this study is to evaluate the efficacy and safety of botulinum toxin A in patients with herpes zoster pain. Methods: Seventy-five patients with herpes zoster pain were enrolled. We reviewed the medical records and divided the patients into three groups according to the treatment they received: standard treatment with botulinum toxin A, standard treatment only, and standard treatment with normal saline injection. Data on patients`` age, sex, involved dermatome, and the duration and severity of pain evaluated with the visual analogue scale (VAS) were collected. Botulinum toxin A (1 unit/1 cm2, total 10∼20 units) was injected intradermally, and the patients were evaluated on initial visit, and at 1 and 28 days after injection. Results: In concordance with previous studies, this study showed that botulinum toxin A had a rapid and considerable effect on reducing both acute and postherpetic pain. The mean VAS was 6.96 on initial visit, 2.90 after 1 day, and 2.03 after 28 days in the botulinum toxin injection group. This result was statistically significant (p< 0.001) when compared with the standard treatment group and the standard treatment with normal saline injection group. Few adverse effects were observed. Conclusion: Intradermal injection of botulinum toxin A is an effective and safe method for reducing pain in patients with herpes zoster. (Korean J Dermatol 2014;52(12):845∼850)

UCI(KEPA)

I410-ECN-0102-2015-500-002299294

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • :
  • : 학술지
  • : 연속간행물
  • : 1960-2020
  • : 9294


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1원저 : 변형된 삼극 전진 피판술을 이용한 피부 결손부 복원의 임상적 의의

저자 : 남궁선 ( Sun Nam Koong ) , 김지석 ( Ji Seok Ki ) , 김지영 ( Jee Young Ki ) , 계지원 ( Ji Won Gye ) , 홍승필 ( Seung Phil Hong ) , 김명화 ( Yung Hwa Ki ) , 박병철 ( Byung Cheol Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 839-844 (6 pages)

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Background: Triple advancement flap has been recently introduced to close the skin defect after Mohs microscopic surgery. Objective: The aim of this study is to evaluate the clinical advantage of the modified triple advancement flap compared with rhomboid excision and closure. Methods: The modified triple advancement flap was performed on nine patients with skin cancer. We observed the clinical course after surgery and compared the scar length and the amount of removed normal skin in triple advancement flap with those in rhomboid excision and primary closure, by using an image-analyzing program. Results: The overall cosmetic and functional result was good. Partial flap necrosis was detected in one of nine patients, and hypertrophic scar developed in one of nine patients. The average scar length from the modified triple advancement flap was 102.1 mm, whereas it was 95.0 and 111.0 mm in 1:3 and 1:3.5 rhomboid excision with closure. The amount of removed skin was 716.3 mm2 in modified triple advancement flap, whereas it was 794.0 mm2 (1:3) and 1116.9 mm2 (1:3.5) in rhomboid excision with closure. Conclusion: The triple advancement flap might be used to close a defect in the area of trifurcation or bifurcation of skin tension lines, to spare the normal surrounding tissue as much as possible. (Korean J Dermatol 2014;52(12): 839∼844)

2원저 : 대상포진 통증에 대한 Botulinum Toxin A의 효과

저자 : 한길 ( Gil Han ) , 김수현 ( Soo Hyun Kim ) , 이규석 ( Kyu Suk Lee ) , 조재위 ( Jae We Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 845-850 (6 pages)

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Background: Many strategies are currently used to reduce herpes zoster pain, such as opioid analgesic administration and transcutaneous electrical nerve stimulation. However, a more effective and convenient method to reduce herpes zoster pain is needed. Objective: The purpose of this study is to evaluate the efficacy and safety of botulinum toxin A in patients with herpes zoster pain. Methods: Seventy-five patients with herpes zoster pain were enrolled. We reviewed the medical records and divided the patients into three groups according to the treatment they received: standard treatment with botulinum toxin A, standard treatment only, and standard treatment with normal saline injection. Data on patients`` age, sex, involved dermatome, and the duration and severity of pain evaluated with the visual analogue scale (VAS) were collected. Botulinum toxin A (1 unit/1 cm2, total 10∼20 units) was injected intradermally, and the patients were evaluated on initial visit, and at 1 and 28 days after injection. Results: In concordance with previous studies, this study showed that botulinum toxin A had a rapid and considerable effect on reducing both acute and postherpetic pain. The mean VAS was 6.96 on initial visit, 2.90 after 1 day, and 2.03 after 28 days in the botulinum toxin injection group. This result was statistically significant (p< 0.001) when compared with the standard treatment group and the standard treatment with normal saline injection group. Few adverse effects were observed. Conclusion: Intradermal injection of botulinum toxin A is an effective and safe method for reducing pain in patients with herpes zoster. (Korean J Dermatol 2014;52(12):845∼850)

3원저 : 얼굴 모공 분포와 모공에 영향을 미치는 요인에 관한 연구

저자 : 정혜정 ( Hye Jung Jung ) , 서현이 ( Hyun Yi Suh ) , 심주현 ( Joo Hyun Shim ) , 이갑석 ( Kap Sok Li ) , 안지영 ( Ji Young Ahn ) , 박미연 ( Mi Youn Park ) , 홍창권 ( Chang Kwun Hong ) , 윤재일 ( Jai Il Youn ) , 김범준 ( Beom Joon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 851-857 (7 pages)

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Background: Pores are the openings of the pilosebaceous unit or the apocrine gland. Increase in pore size or in the number of dilated pores may be a cosmetic problem. To date, epidemiological studies on the numbers of dilated pores have been rarely reported. Objective: To analyze the distribution of pores and the factors affecting pores. Methods: We compared the number of dilated facial pores on the face according to site, age group, and sex. The relations of pore counts to wrinkle severity and to the amount of hydration were also analyzed. DermavisionTM, a device that can take cross-polarization, parallel polarization, and ultraviolet light images, was used. Parameters were measured at three points: the forehead, cheek, and nose. Results: The results revealed that dilated pores were more common on the nose and forehead. The pore counts were increased with age, and the increment was significant between participants in their 30s and 40s. Moreover, dilated pore counts were affected by wrinkle severity. The amount of hydration did not affect the counts of dilated pores. Conclusion: In this study, the number of dilated pores differed depending on the location. Moreover, it was confirmed that pore counts were higher in older persons. The pore counts showed a correlation with wrinkle severity. (Korean J Dermatol 2014;52(12):851∼857)

4원저 : 편평 사마귀의 발생: 피부 관리실과 병의원에서의 피부관리가 미치는 영향

저자 : 채인수 ( In Soo Chae ) , 박경덕 ( Kyung Duck Park ) , 박준수 ( Joon Soo Park ) , 정현 ( Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 858-863 (6 pages)

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Background: Verruca plana is a common viral disease that commonly affects the face. It can autoinoculate or autotransmit, as well as cause many cosmetic problems. Skin care material that had direct contact with the skin of an affected person during a skin care procedure can be a transmission route of verruca plana or a risk factor of autoinoculation of the virus. Objective: The goal of this study is to compare skin care behavior between skin care clinics and skin care shops, and the effects on verruca plana transmission. Methods: Seventy-four patients who visited local dermatology clinics in Daegu from January 2011 to January 2013 were selected randomly, and a questionnaire survey was done. Results: The incidence of verruca plana in patients visiting the clinic to receive skin care was higher than in the normal population. There was a statistically significant correlation between the number of procedures and the incidence of verruca plana in both skin care clinics and skin care shops. Whereas the number of verruca plana cases increased with the increase in the number of procedures in skin care shops, there was no significant correlation between the number of procedures and the incidence of verruca plana in skin care clinics. Conclusion: The number of procedures was significantly correlated with the incidence of verruca plana. In persons receiving treatment in skin care shops, the incidence of verruca plana increased with the increase in the number of procedures. (Korean J Dermatol 2014;52(12):858∼863)

5원저 : 눈꺼풀 피부 악성 종양의 모즈 미세도식 수술 후 결손부의 복원

저자 : 고혜림 ( Hye Rim Ko ) , 민정아 ( Jung Ah Min ) , 이영복 ( Young Bok Lee ) , 한형진 ( Hyung Jin Hahn ) , 김진우 ( Jin Wou Kim ) , 유동수 ( Dong Soo Yu )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 864-872 (9 pages)

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Background: The reconstruction of eyelid defects is extremely complex because both functional and aesthetic aspects should be considered. Numerous techniques for reconstruction are available for repairing eyelid defects, depending on the size, location, and extent of the defect. Objective: This study was aimed at assessing the effectiveness and cosmetic consequences of various reconstruction techniques for eyelid defects after Mohs micrographic surgery. Methods: Twenty patients who received a diagnosis of skin cancer of the eyelids from November 2005 to August 2009 were analyzed. Among them, 15 patients were treated with a local flap to reconstruct the defective eyelids, and the remaining patients were treated with primary closure. The medical records and photographs were reviewed by two independent physicians, and postoperative results were evaluated. Results: Eyelid defects were reconstructed with various surgical techniques, such as primary closure, transposition flap, subcutaneous island pedicle flap, advancement flap, rotation flap, Tenzel flap, and hard palate mucous membrane graft. The cosmetic results were satisfactory, and 16 of 20 (80%) patients showed good to excellent results. However, one patient developed a sclera show and another patient showed tumor recurrence. Conclusion: Many reconstruction techniques can be used for eyelid defects. An optimal choice would be one that is based on the extent, depth, and location of the defect; skin condition and wishes of the patient; and the surgeon's experience. Furthermore, it is important to have an understanding of the anatomy of the eyelid, the basic principles of the reconstruction techniques, and the merits and drawbacks of each technique. (Korean J Dermatol 2014; 52(12):864∼872)

6원저 : 건강검진자를 대상으로 한 자외선 노출, 체내 지방 분포, 대사 변화와의 관련성에 대한 단면적 관찰 연구

저자 : 백유진 ( Yu Jin Paek ) , 구상현 ( Sang Hyeon Ku ) , 권인호 ( In Ho Kwon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 873-879 (7 pages)

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Background: The age-associated loss of subcutaneous fat with the accumulation of visceral fat consequently leads to several deleterious health outcomes such as dyslipidemia, insulin resistance, and metabolic syndrome. A recent research has shown that acute ultraviolet (UV) irradiation can reduce subcutaneous fat. Objective: The purpose of our study is to investigate whether chronic UV radiation can reduce subcutaneous fat, increase visceral fat, and lead to additional metabolic changes. Methods: We analyzed the abdominal computed tomography images of the 98 subjects attending our health examination center to calculate the amount of subcutaneous fat and visceral fat. Questionnaire surveys were conducted to analyze the degree of daily UV exposure, sunscreen use, and physical activity. Weight, height, blood pressure (BP), liver function test, lipid profiles, and glucose metabolism were also assessed. Results: In the analysis of covariance adjusted for age, sex, and physical activity, the visceral fat amount in the high UV exposure group was significantly higher than that in the low UV exposure group (p=0.043), and the subcutaneous/total fat ratio in the high UV group was significantly lower than that in the low UV group (p=0.048). The high UV group had higher levels of fasting insulin, homeostasis model assessment of insulin resistance, systolic BP, and diastolic BP than the low UV exposure group (p=0.039, 0.012, 0.004, and 0.002, respectively). Conclusion: Our results suggest that chronic UV radiation could change body fat distribution and lead to additional changes, including changes in glucose metabolism and BP. (Korean J Dermatol 2014;52(12):873∼879)

7증례 : 등에 발생한 선천성 점액모반 1예

저자 : 주홍진 ( Hong Jin Joo ) , 유현주 ( Hyun Ju Yoo ) , 김정은 ( Jung Eun Kim ) , 강훈 ( Hoon Kang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 892-894 (3 pages)

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Mucinous nevus is a rare entity classified as either cutaneous mucinosis or connective tissue nevi. Clinically, grouped papules or plaques grow to form a verrucous or nevoid feature usually on the trunk. It can be present since birth or early childhood. Histologically, it consists of mucin deposits localized in the superficial dermis with or without epidermal changes. An 18-year-old boy presented with asymptomatic multiple grouped brown papules and coalescent plaques on his lower back that had been present since birth. Histological examination showed a band-like mucin deposit in the papillary dermis. To our knowledge, there have been only few reports of mucinous nevus in the literature. Here, we report a case of mucinous nevus present since birth, including a review of relevant literature. (Korean J Dermatol 2014;52(12):892∼894)

8증례 : 악성 흑색종과 동반된 Leser-Trelat 징후

저자 : 이동엽 ( Dong Yeup Lee ) , 백종헌 ( Jong Heon Baek ) , 김동주 ( Dong Joo Kim ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee ) , 박현수 ( Hyun Su Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 895-899 (5 pages)

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Leser-Trelat sign is a rare paraneoplastic dermatosis that is characterized by the eruptive and rapid development of multiple seborrheic keratosis that coincides with an internal malignancy. Eruptive seborrheic keratosis can be pruritic and appear in a “Christmas-tree pattern.” This sign occurs in association with a number of cancers, such as adenocarcinoma of the gastrointestinal tract and various lymphoproliferative disorders. However, Leser-Trelat sign associated with a malignant melanoma is very rare. A 58-year-old male patient presented with an asymptomatic black mass on the penile orifice and patch on the glans penis. He complained of gross hematuria. At the same time, he developed asymptomatic multiple brown papules and plaques on the back. The histopathologic findings of the glans and back lesions were consistent with malignant melanoma and seborrheic keratosis, respectively. Here, we describe a rare case of Leser-Trelat sign associated with malignant melanoma. (Korean J Dermatol 2014;52(11):895∼ 899)

9증례 : 잔물결모양 피지선상피종 1예

저자 : 김주익 ( Joo Ik Kim ) , 우수한 ( Soo Han Woo ) , 김대우 ( Dae Woo Kim ) , 황수란 ( Su Ran Hwang ) , 이진호 ( Chin Ho Rhee ) , 박진 ( Jin Park ) , 김한욱 ( Han Uk Kim ) , 윤석권 ( Seok Kweon Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 900-902 (3 pages)

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Rippled-pattern sebaceoma, a very rare histologic variant of sebaceoma, manifests as a peculiar arrangement of basaloid cells in linear and parallel rows, resembling Verocay bodies. It represents dermal aggregations composed of small, monomorphous, basaloid, sebaceous germinative cells. It has a tendency to occur in men, with the scalp as the predilection site. To our knowledge, only one case has been reported to date in the Korean dermatologic literature. Here, we report a case of rippled-pattern sebaceoma that appeared as a flesh nodule on the occiput and had been present for 4 years in a 41-year-old man. (Korean J Dermatol 2014;52(12):900∼902)

10증례 : Dermoscopy 소견상 기저세포암의 특징을 보인 Milia En Plaque 1예

저자 : 김민성 ( Min Sung Kim ) , 윤상호 ( Sang Ho Youn ) , 나찬호 ( Chan Ho Na ) , 신봉석 ( Bong Seok Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 12호 발행 연도 : 2014 페이지 : pp. 903-906 (4 pages)

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Dermoscopy is a noninvasive technique that is known to increase the accuracy of diagnosing benign versus malignant skin lesions. Milia en plaque is a rare benign epidermal tumor characterized by multiple milia-like lesions within the erythematous edematous base. It arises spontaneously on healthy skin in predisposed individuals without any apparent cause. An 80-year-old woman presented with a solitary coin-sized yellowish to brown plaque on the right cheek. The lesion has been enlarging for several years. Dermoscopic examination showed arborizing telangiectasia, and we suspected it to be basal cell carcinoma. Two biopsies were taken from the lesion, which revealed a keratin-filled cyst lined by a stratified epithelium of a few cell layers and sparse lymphocytic infiltration. Therefore, we diagnosed the lesion as milia en plaque, histopathologically. On the basis of our experience with a case of milia en plaque diagnosed as a basal cell carcinoma with dermoscopic findings, we believe that benign lesions should be considered even in the presence of malignant findings on dermoscopy. (Korean J Dermatol 2014;52(12):903∼906)

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대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호

프로그램북(구 초록집)
71권 1호 ~ 71권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 9호 ~ 57권 9호

프로그램북(구 초록집)
71권 2호 ~ 71권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 6호 ~ 31권 6호

프로그램북(구 초록집)
71권 2호 ~ 71권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 6호 ~ 31권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 3호 ~ 45권 3호

KCI등재 SCOUPUS

대한피부과학회지
57권 8호 ~ 57권 8호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 5호 ~ 31권 5호

한국피부장벽학회지
21권 1호 ~ 21권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 7호 ~ 57권 7호

KCI등재 SCOUPUS

대한피부과학회지
57권 6호 ~ 57권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 2호 ~ 45권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 44호 ~ 31권 44호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 4호 ~ 31권 s4호

KCI등재 SCOUPUS

대한피부과학회지
57권 5호 ~ 57권 5호
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