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대한피부과학회> 대한피부과학회지> 만성 경과를 보이는 쇼그렌 증후군의 환상 홍반을 Hydroxychloroquine으로 치료한 1예

KCI등재SCOUPUS

만성 경과를 보이는 쇼그렌 증후군의 환상 홍반을 Hydroxychloroquine으로 치료한 1예

A Case of Recurrent Annular Erythema of Sjogren`s Syndrome Treated with Hydroxychloroquine

이지혜 , 김종훈 , 성재용 , 이승헌
  • : 대한피부과학회
  • : 대한피부과학회지 52권1호
  • : 연속간행물
  • : 2014년 01월
  • : 64-66(3pages)

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UCI(KEPA)

I410-ECN-0102-2014-500-001915417

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2020
  • : 9429


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1HaCaT 각질형성세포 및 섬유아세포에서 말기름의 항세균, 염증성 사이토카인 및 제 1형 교원질 발현에 대한 영향

저자 : 최경화 ( Kyoung Hwa Choi ) , 이영선 ( Young Sun Lee ) , 윤지현 ( Ji-Hyun Yoon ) , 유왕근 ( Wang Keun Yoo ) , 김미려 ( Mi Ryeo Kim ) , 이규석 ( Kyu Suk Lee ) , 조재위 ( Jae We Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 1-6 (6 pages)

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Background: Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown. Objective: The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type I collagen of horse oil. Methods: Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines were studied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in human HaCaT kertinocytes and fibroblasts. Results: Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10 was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observed in horse oil-treated human skin fibroblasts. Conclusion: Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatory and anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively. (Korean J Dermatol 2014;52(1):1∼6)

2Perfecthaⓡ 필러 2종에 대한 제형 특성 연구

저자 : 송이섭 ( Yi Seop Song ) , 김형미 ( Hyeong Mi Kim ) , 이용희 ( Yonghee Lee ) , 손인평 ( In Pyeong Son ) , 박귀영 ( Kui Young Park ) , 이갑석 ( Kapsok Li ) , 김범준 ( Beom Joon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 7-12 (6 pages)

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Background: Hyaluronic acid (HA) is a carbohydrate, occurring naturally throughout the human body. With linear polysaccharide structure, it is (HA) found in soft connective tissues, cartilage and joinfluids. Hyaluronic acid filler is used for treatment of depth of the fold or volume of filler needed and performed for wrinkle improvement and cosmetic. We did property of matter for the Perfecthaⓡ fillers. Objective: Our purpose is to describe and comment on our experiences with two kinds of Perfecthaⓡ fillers. Methods: We obtained image of the shape of fillers using a folliscope, VC98 and particle size using the Scanning electron microscope (SEM). We tested to make sure that affinity both fillers with water. We mixed the fillers and distilled water. We the PARKER ink added to the mixture. Viscosity and elasticity were measured using a Results: The test revealed that a particle sized Perfecthaⓡ derm deep is bigger than a Perfecthaⓡ derm. We were confirmed as hydrophile. While Perfecthaⓡ derm deep filler has high viscosity and elasticity, Perfecthaⓡ derm filler Conclusion: Two kinds of Perfecthaⓡ fillers act as space filler by binding to water and thus keeping the skin wrinkle-free. (Korean J Dermatol 2014;52(1):7∼12)

3발바닥의 종양 제거 후 결손부의 복원

저자 : 이 준 ( Joon Lee ) , 이승재 ( Seung-Jae Lee ) , 박지혜 ( Ji-Hye Park ) , 이가영 ( Ga-Young Lee ) , 김원석 ( Won-Serk Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 13-19 (7 pages)

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Background: The plantar aspect of the foot is a difficult area for wound coverage and offers restricted/limited possibility for surgical repair. Due to the shearing and ground-reactive forces that the sole of the foot encounters and its unique organizational makeup of plantar skin and fat pad, reconstructive surgical techniques used on other parts of the body cannot be readily adapted to the plantar foot. Objective: The authors present an overview of wound repair after excision of benign or malignant tumor on plantar area. Methods: Retrospective review was done on 27 patients whose benign or malignant tumors on the plantar area were excised. From January 2007 to December 2012, we repaired defects on the plantar foot after simple excision of benign cutaneous tumors or wide excision of malignant melanomas. Patients were reviewed for results and complications. Results: Simple elliptical closure was used for the defects of which the short diameter was below 1.5 cm in 13 patients. Transposition flap was used in 2 patients. The local flap was used when the length to width ratio was smaller than 3 to 1, and the laxity of the skin adjacent to the defect was available. Larger defects of other 12 cases needed to be reconstructed with full thickness skin graft (FTSG) or by secondary intention healing (SIH). The re-epithelialization was shown to be faster in the FTSG group, but the functional and cosmetic results were better in the SIH group. Conclusion: Many defects on the sole were difficult to repair because of the distinct anatomy. In order to treat such large wounds in weight bearing area, both FTSG and SIH are relatively good options. (Korean J Dermatol 2014;52(1):13∼19)

4켈로이드의 절제술 후 방사선 치료가 재발 억제에 미치는 효과

저자 : 심현철 ( Hyun Chul Shim ) , 주민숙 ( Mihn Sook Jue ) , 김은정 ( Eun Jung Kim ) , 이종은 ( Jong Eun Lee ) , 박향준 ( Hyang Joon Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 20-25 (6 pages)

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Background: The treatment of keloids is unsatisfactory and even a challenge to many dermatologists or dermatosurgeons. Simple excision of a keloid alone is associated with a high recurrence rate. Thus, surgical treatment should be combined with various adjuvant therapies. Objective: The aim of this study was to evaluate the efficacy of postoperative radiation therapy on the recurrence of keloids. Methods: Between March 2007 and May 2012, 24 patients with keloids (n=56) in various anatomical sites were treated with our protocol consisting of total or subtotal keloidectomy followed by immediate irradiation of 12∼18 Gy in 3 fractions over 3 days with pre- and postoperative intralesional steroid injection as an adjuvant therapy. After a year to a year and a half, treatment was terminated at that point. Results: When treated keloids were classified according to the degree of flattening, the outcomes were excellent in 48.2% (27/56) of the patients, good in 32.1% (18/56), fair in 14.3% (8/56), and poor in 5.3% (3/56). This treatment protocol showed almost excellent outcomes in earlobe, earhelix, retroauricular region and abdomen. Although the sites with high stretch tension such as chest and shoulder showed above good outcomes (72%, 18/25), they also showed three poor results. The most common complication was postinflammatory hyperpigmentation while the most serious one was full-thickness skin necrosis, which was recovered by skin graft later. Conclusion: Radiation therapy is an effective and safe therapy for the prevention of recurrence of keloids following keloidectomy. (Korean J Dermatol 2014;52(1):20∼25)

5피부 부정형미코박테륨 감염의 임상적, 미생물학적 및 조직학적 소견에 대한 연구

저자 : 장민수 ( Min Soo Jang ) , 한상화 ( Sang Hwa Han ) , 김상태 ( Sang Tae Kim ) , 서기석 ( Kee Suck Suh )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 26-33 (8 pages)

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Background: As the immunocompromised population has increased in recent years, the number of cutaneous nontuberculous mycobacterial (NTM) infections has also risen. However, since this affliction has no pathognomonic clinical or histological features, the diagnosis and treatment of cutaneous NTM infections are often delayed. Objective: The aim of this study was to investigate the microbiological, clinical, and histological findings of cutaneous NTM infections. Methods: We reviewed medical records and histologic slides of 10 patients diagnosed with cutaneous NTM infections confirmed by culture or polymerase chain reaction. Results: All patients except one were immunocompetent, and 5 of 10 patients had preceding factors including trauma, liposuction, and intralesional triamcinolone injection. Microbiologically, of the 10 infections, 5 were caused by Mycobacterium marinum, 3 by Mycobacterium fortuitum, and 1 each by Mycobacterium chelonae and Mycobacterium ulcerans, respectively. Of the 5 patients with M. marinum, 2 had a fish-related job and 1 reared fish at a home aquarium. The most common clinical presentation was erythematous nodules (7/10). Histologically, irregular acanthosis (4/10), mixed cell infiltrate of lymphocytes, histiocytes, neutrophils (9/10), suppurative granuloma (7/10), microcysts lined by neutrophils (5/10), fibrosis (4/10), and panniculitis (7/10) were identified. Conclusion: We found microcysts lined by neutrophils in 50% of the samples and considered this finding to be a diagnostic marker of NTM infection. These clinicopathologic features will assist clinicians in diagnosing NTM infection more rapidly and accurately. (Korean J Dermatol 2014;52(1):26∼33)

6간암환자에서 발생한 종양수반성 천포창

저자 : 장민수 ( Min Soo Jang ) , 이강훈 ( Kang Hoon Lee ) , 한상화 ( Sang Hwa Han ) , 박종빈 ( Jong Bin Park ) , 이지범 ( Jee Bum Lee ) , 서기석 ( Kee Suck Suh )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 34-39 (6 pages)

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PNP is a rare autoimmune mucocutaneous blistering disease associated with neoplasms, most frequently of the lymphoproliferative type. As PNP is clinically characterized by polymorphous mucosal lesions and cutaneous eruptions, it is important to differentiate it from erythema multiforme, Stevens-Johnson syndrome, lichen planus, and other bullous diseases. A diagnosis of PNP can be confirmed by immunologic studies such as direct and indirect immunofluorescence, immunoblotting, immunoprecipitation. Rare PNP cases related to nonhematological solid tumors have been reported. A 54-year-old male visited us with generalized pruritic scaly lichenoid lesions on the whole body from 5 weeks prior to his first visit. He also presented with extensive painful ulcers and erosions on the oral mucosa and lips for 2 months. Histopathologic findings showed lichenoid infiltration with vacuolar interface change, lichenoid interface dermatitis, keratinocyte apoptosis, and suprabasal acantholysis with cleft. Indirect immunofluorescence using normal human skin showed IgG deposition at the intercellular space. Immunoblotting using normal epidermal extracts in the serum of patient detected antibody to the 190 kDa (envoplakin), 210 kDa (periplakin) molecules polypeptides. He also had a hepatocellular carcinoma and chemoradiotherapy done before. The diagnosis of paraneoplastic pemphigus (PNP) was made. To our knowledge, there are only two reports of PNP associated with hepatocellular carcinoma worldwide, yet no report in Korean literature. Herein, we report the first case of PNP associated with hepatocellular carcinoma in Korea. (Korean J Dermatol 2014;52(1):34∼39)

7만성 B형 간염 환자에서 Pegylated 인터페론 알파2a 치료 중 발생한 원형 탈모

저자 : 김예슬 ( Ye Seul Kim ) , 이강모 ( Gang Mo Lee ) , 배유인 ( You In Bae ) , 박영립 ( Young Lip Park ) , 이상훈 ( Sang Hoon Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 40-43 (4 pages)

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Recent studies recommend pegylated interferon alpha2a as the first choice treatment for chronic hepatitis B, especially when the patient is negative for HBeAg. Pegylated interferon alpha is known to show variable side effects including skin symptoms, with alopecia as the most common dermatologic side effect experienced for 10% up to 36%. pcc) Most alopecia cases related to pegylated interferon alpha were presented with telogen effluvium pattern, but alopecia areata cases are reported rarely. In this case, typically localized alopecia areata was presented with pegylated interferon alpha2a treatment in hepatitis B patient, and the course of alopecia areata seemed to be related with administration and discontinuation of pegylated interferon alpha2a. (Korean J Dermatol 2014;52(1):40∼43)

8기저질환이 없이 성인에서 발생한 무균성 피하 농양

저자 : 김형래 ( Hyeong Rae Kim ) , 임은화 ( Eun Wha Lim ) , 이 영 ( Young Lee ) , 서영준 ( Young Joon Seo ) , 이증훈 ( Jeung Hoon Lee ) , 임 명 ( Myung Im )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 44-47 (4 pages)

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Aseptic subcutaneous abscesses are characterized by deep, round lesions histologically consisting of neutrophils, without evidence of microorganisms on culture. Although these are sometimes reported in healthy individuals, most are reported in patients with inflammatory bowel disease, including Crohn's disease and ulcerative colitis. A 79-year-old man without underlying disease presented with multiple skin-colored nodules and masses on his face and extremities 4 years ago. All of the microbiology studies for bacteria and fungi were negative and he did not respond to antibiotics. However, the lesions improved markedly after systemic prednisolone treatment. We diagnosed his lesions as aseptic subcutaneous abscesses. Further studies to evaluate inflammatory bowel disease were negative. Here, we report a case of multiple aseptic subcutaneous abscesses without an underlying disease. (Korean J Dermatol 2014;52(1):44∼47)

9손가락에 발생한 파치니 신경종 2예

저자 : 공태석 ( Tae Seok Kong ) , 한태영 ( Tae Young Han ) , 이현경 ( June Hyunkyung Lee ) , 손숙자 ( Sook-Ja Son )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 48-51 (4 pages)

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Pacinian neuroma is a rare skin disease characterized by hyperplasia or hypertrophy of the Vater-Pacini corpuscles which are responsible for the appreciation of deep pressure and vibration. It usually affects the volar aspects of the fingers in middle-aged adults and it produces severe pain and tenderness on the affected skins. About half of previously reported cases revealed the association with precipitating factors such as local trauma, but underlying mechanisms are not established. Two patients presented with a several months history of solitary pale-colored papule on the tip of finger. The patients reported a severe tenderness on the lesion with a history of repetitive trauma. The histopathologic examination from the lesions showed increased number of onion-like stratified structures around nerve fibers, compared to the usual density of pacinian corpuscles (3∼5/cm2). The histopathological features were consistent with pacinian neuroma. The symptoms of the patients disappeared soon after the surgery. Herein, we present two patients with pacinian neuroma on the finger, and we also propose that pacinian neuroma should be considered for the differential diagnosis of tender papule on the digit.

10단발성 홍반 결절 형태로 나타난 기저양 편평세포암종

저자 : 홍정호 ( Jeong Ho Hong ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 52권 1호 발행 연도 : 2014 페이지 : pp. 52-55 (4 pages)

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Basaloid Squamous Cell Carcinoma Manifested as a Solitary Erythematous Nodule Jeong Ho Hong, M.D., Jeong Eun Kim, M.D., Joo Yeon Ko, M.D., Young Suck Ro, M.D. Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea Basaloid squamous cell carcinoma (BSCC) is a rare malignancy, which has a predilection for the upper aerodigestive tract. A 78-year-old man presented with solitary erythematous nodule on the right neck. The tumor mass was rapidly enlarged for last 5 months and firmly attached to deep soft tissue. Neck computed tomography showed enhanced density in vallecular region and enlarged cervical lymph nodes. Wide excision of the tongue base with modified lymph node dissection, including the solitary erythematous nodule, was performed. Histopathologically, the tongue base and cutaneous lesion displayed closely packed basaloid cells with comedonecrosis and squamous eddy formation. The cells demonstrate a high nuclear to cytoplasmic ratio and abundant mitotic figures. Staining for p63, cytokeratin 5 (CK5) demonstrated diffuse uptake within the tumor and CD56 stain was negative. We diagnosed this case as the first Korean case of metastatic cutaneous BSCC.

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주제별 간행물
간행물명 수록권호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 5호 ~ 32권 5호

KCI등재 SCOUPUS

대한피부과학회지
58권 8호 ~ 58권 8호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 3호 ~ 46권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 7호 ~ 58권 7호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 4호 ~ 32권 4호

KCI등재 SCOUPUS

대한피부과학회지
58권 6호 ~ 58권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 2호 ~ 46권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 5호 ~ 58권 5호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 4호 ~ 58권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 1호 ~ 46권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 3호 ~ 58권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 2호 ~ 32권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 2호 ~ 58권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호

프로그램북(구 초록집)
71권 1호 ~ 71권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 9호 ~ 57권 9호
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