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대한피부과학회> 대한피부과학회지> Merkel 세포암에 대한 임상병리학적 고찰

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Merkel 세포암에 대한 임상병리학적 고찰

A Clinicopathologic Study of Merkel Cell Carcinoma

박언재 ( Oun Jae Park ) , 원종현 ( Chong Hyun Won ) , 장성은 ( Sung Eun Chang ) , 이미우 ( Mi Woo Lee ) , 최지호 ( Jee Ho Choi ) , 문기찬 ( Kee Chan Moon )
  • : 대한피부과학회
  • : 대한피부과학회지 50권2호
  • : 연속간행물
  • : 2012년 02월
  • : 106-113(8pages)
피인용수 : 37건

(자료제공: 네이버학술정보)

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Background: Merkel cell carcinoma is a rare neuroendocrine tumor that typically presents as indurated nodules in elderly patients. It has an aggressive behavior and thus, such incidence has been increasing. Objective: Our purpose was to analyze clinical and histological characteristics of Merkel cell carcinoma, and to obtain a better understanding of this rare malignancy. Methods: We conducted a clinicopathologic evaluation of 11 patients from our center during 21 year period (1989~2010). We investigated personal and clinical information, including age, sex, time of onset, past history, histologic findings and clinical manifestations. Results: The age of the 11 patients ranged from 48 to 84, and the mean age of onset was 62.3, with a slight female predominance (1:1.7). The most prevalent site was the face then followed by the extremities. Subcutaneous nodular lesion with overlying erythema was the most common finding (72.7%, 8/11). Protruding tumorous lesions were 18.2% (2/11) and palpable lymphadenopathy was 9.1% (1/11), respectively. Histopathologically, pleomorphic atypical cells and granular nuclear dots ("salt and pepper") were observed. Immunohistochemical study showed positivity for pan-cytokeratin (CK), cytokeratin (CK20), CD56, synaptophysin, chromogranin (90%, 81.8%, 100%, 85.7%, 83.3%) and negative result for leukocyte common antigen (LCA, 0/7), and thyroid transcription factor-1 (TTF-1, 0/4), S100 (0/4). Conclusion: Merkel cell carcinomas were more frequent in old females and were rare in immunocompromised patients in Korea. Histologic and immunohistochemical features were similar to previous studies, but there was a case of rare type (CK7+/CK20-) of Merkel cell carcinoma. Surgery is a treatment of choice in Merkel cell carcinoma. But radiation or chemotherapy can be used as an adjuvant therapy. Based on this study, characteristics of Merkel cell carcinoma in Korea can be elucidated with more future cases. (Korean J Dermatol 2012;50(2):106~113)

UCI(KEPA)

I410-ECN-0102-2012-510-002633374

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2020
  • : 9394


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1강원지역에서 10년간(1999~2008) 내원 환자 중 피부악성종양과 피부암전구증에 관한 임상적 고찰

저자 : 홍한나 ( Han Nah Hong ) , 지재홍 ( Jae Hong Ji ) , 최응호 ( Eung Ho Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 95-100 (6 pages)

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Background: The incidence of cutaneous malignant tumors and premalignant lesions has recently increased according to extended life span, social and medical environment changes. However, a few clinical data have been reported on the survey of cutaneous malignant tumors and premalignant lesions in Gangwon province. Objective: To investigate the incidence and clinical patterns of cutaneous malignant tumors and premalignant lesions in Gangwon province. Methods: We reviewed 485 cases of cutaneous malignant tumors and premalignant lesions from January 1999 to December 2008, at the Department of Dermatology at Wonju Christian Hospital. Results: The average annual incidence of cutaneous malignant tumors among the total number of outpatients was 0.51% and that of premalignant lesions was 0.48%. Both incidences tended to increase with time in 10 year intervals. The most common cutaneous malignant tumor was basal cell carcinoma (47.98%), followed by squamous cell carcinoma (24.19%), extramammary paget`s disease (7.26%), metastatic cancer (5.65%), malignant melanoma (4.44%), and lastly, lymphoma (4.44%). Among premalignant lesions, actinic keratosis (74.68%) and Bowen`s disease (25.32%) were common. The mean age of onset was 67.53 years in cutaneous malignant tumors and 70.51 years in premalignant lesioins. The most common site for both, the cutaneous malignant tumors and premalignant tumors, was the face (63.97% and 81.43%, respectively). The ratio of men to women was 1.11:1 in cutaneous malignant tumors and 1:2.48 in premalignant lesions. Conclusion: The incidence of cutaneous malignant tumors and premalignant lesions has gradually increased in Gangwon province. This data will be made available for the study about the association of cutaneous malignant tumors and premalignant lesions. (Korean J Dermatol 2012;50(2):95~100)

2광선각화증에서 비정형세포층의 두께 및 조직학적 아형에 따른 Blue Light를 이용한 ALA-PDT의 치료효과 비교

저자 : 정소영 ( So Young Jung ) , 홍순권 ( Soon Kwon Hong ) , 서종근 ( Jong Keun Seo ) , 성호석 ( Ho Suk Sung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 101-105 (5 pages)

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Background: Precancerous diseases of the skin such as actinic keratosis (AK), Bowen disease (BD) and skin cancer, i.e. basal cell carcinoma (BCC), are treated successfully with photodynamic therapy (PDT). In BCC, the therapeutic effect of PDT was different according to the subtypes. However, there has been no study on the response to PDT in the thickness of atypical cell layer and the histopathologic subtype of AK. Objective: We evaluated the responses to PDT using a topical 20% aminolevulinic acid (ALA) solution and a blue light, according to the thickness of atypical cell layer in AK. Further, we assessed the therapeutic response in the histopathologic subtypes of AK. Methods: There were a total of 29 AK lesions from 20 patients enrolled in the study. The lesions were incubated with a topical 20% ALA solution for 2 hours and were exposed to blue light (417±5 nm) with 10 J/cm2. They were treated 2 times at the 4 weeks intervals. The evaluation of the response to ALA-PDT was done by the skin biopsy at the post 8 weeks period from the last treatment. The therapeutic response was assessed into 3 grades (complete remission, partial remission, no response). The relationship between the therapeutic response and the thickness of atypical cell layer was evaluated. The thickness of atypical cell layer was measured from the most superficial aspect of the Malpighian layer to the tip of rete ridge. In addition, we evaluated the therapeutic effects according to the histopathologic subtypes. Results: The thickness of atypical cell layer were 0.0327±0.0087 mm in complete remission (CR) group, 0.1253±0.1128 mm in partial remission (PR) group and 0.1485±0.1973 mm in no response (NR) group (p=.0206). CR were achieved in 100% (4/4) of atrophic type, 43.75% (7/16) of hypertrophic type and 0% (0/9) of bowenoid type in AK. The response of ALA-PDT was the best in atrophic type (p=.032) and the lowest in bowenoid type (p=.0051) as compared with other subtypes. Conclusion: The responses to ALA-PDT were different in the thickness of atypical cell layer and it was statistically significant. The therapeutic effect was the best in the atrophic type of AK. (Korean J Dermatol 2012;50(2):101~105)

3Merkel 세포암에 대한 임상병리학적 고찰

저자 : 박언재 ( Oun Jae Park ) , 원종현 ( Chong Hyun Won ) , 장성은 ( Sung Eun Chang ) , 이미우 ( Mi Woo Lee ) , 최지호 ( Jee Ho Choi ) , 문기찬 ( Kee Chan Moon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 106-113 (8 pages)

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Background: Merkel cell carcinoma is a rare neuroendocrine tumor that typically presents as indurated nodules in elderly patients. It has an aggressive behavior and thus, such incidence has been increasing. Objective: Our purpose was to analyze clinical and histological characteristics of Merkel cell carcinoma, and to obtain a better understanding of this rare malignancy. Methods: We conducted a clinicopathologic evaluation of 11 patients from our center during 21 year period (1989~2010). We investigated personal and clinical information, including age, sex, time of onset, past history, histologic findings and clinical manifestations. Results: The age of the 11 patients ranged from 48 to 84, and the mean age of onset was 62.3, with a slight female predominance (1:1.7). The most prevalent site was the face then followed by the extremities. Subcutaneous nodular lesion with overlying erythema was the most common finding (72.7%, 8/11). Protruding tumorous lesions were 18.2% (2/11) and palpable lymphadenopathy was 9.1% (1/11), respectively. Histopathologically, pleomorphic atypical cells and granular nuclear dots ("salt and pepper") were observed. Immunohistochemical study showed positivity for pan-cytokeratin (CK), cytokeratin (CK20), CD56, synaptophysin, chromogranin (90%, 81.8%, 100%, 85.7%, 83.3%) and negative result for leukocyte common antigen (LCA, 0/7), and thyroid transcription factor-1 (TTF-1, 0/4), S100 (0/4). Conclusion: Merkel cell carcinomas were more frequent in old females and were rare in immunocompromised patients in Korea. Histologic and immunohistochemical features were similar to previous studies, but there was a case of rare type (CK7+/CK20-) of Merkel cell carcinoma. Surgery is a treatment of choice in Merkel cell carcinoma. But radiation or chemotherapy can be used as an adjuvant therapy. Based on this study, characteristics of Merkel cell carcinoma in Korea can be elucidated with more future cases. (Korean J Dermatol 2012;50(2):106~113)

4인천시 동구의 소아 아토피피부염의 위험인자 분석

저자 : 강홍규 ( Hong Kyu Kang ) , 백진옥 ( Jin Ok Baek ) , 이종록 ( Jong Rok Lee ) , 노주영 ( Joo Young Roh )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 114-122 (9 pages)

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Background: Genetic predisposition and environmental aspects may act as triggering factors and influence the disease expression. Dong-gu, which is located on the west of Incheon, has a large harbor and industrial complex. Such environmental aspects of Dong-gu may play a role in AD. Objective: We investigated the epidemiologic features of AD in preschool and elementary school children in Dong-gu. Methods: This study was carried out among 2,760 preschool and elementary school children from June to October. A questionnaire survey is composed of clinical manifestations, genetic and environment factors and lifestyle. Two dermatologists examined the skin conditions of the subjects. The severity of AD was evaluated using the Eczema Area and Severity Index (EASI) score and the factors affecting the severity of the diseases were determined. Results: The questionnaire suggested that there was 19.7% of the preschool childhood and elementary school students in Incheon with AD. But, the prevalence of AD evaluated by the two dermatologists was 13.2%. The average EASI score is 2.88 (±4.08). There was a statistical significance in parental past history, especially of atopic dermatitis and moving into a new house within a year after birth (p<0.05). Conclusion: These results suggest that there is strong correlation of genetic and environmental factors in the severity of atopic dermatitis in children. (Korean J Dermatol 2012;50(2):114~122)

5켈로이드와 비대 흉터에서 Triamcinolone Acetonide와 5-FU (5-Fluorouracil)/Triamcinolone Acetonide 혼합제제의 병변내 주사요법에 관한 비교 연구

저자 : 유창선 ( Chang Sun Yoo ) , 김철우 ( Chul Woo Kim ) , 김상석 ( Sang Seok Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 123-129 (7 pages)

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Background: Keloids and hypertrophic scars may complicate wound healing secondary to trauma or surgery. They are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems for patients. Objective: The purpose of this study was to evaluate the efficacy of using a 5-FU (Fluorouracil)/Triamcinolone acetonide (TCN) mixture to treat keloids and hypertrophic scars. Further, the results were compared via TCN alone. Methods: Patient chart from 2007 to 2011 were reviewed. Patients were stratified into 2 groups: (1) intralesional injection of TCN 0.1 ml (40 mg/ml) mixed with 5-FU 0.9 ml (50 mg/ml), every 2 weeks; (2) intralesional injection of TCN (20 mg/ml), every 2 weeks. Lesions were assessed for height, erythema, pliability, pruritus, pain/tenderness, patient-self assessment and side effects at baseline (initiation of treatment) and at weeks 2, 4, 6. Results: There has been 23 patients (43 lesions) that completed the study. At the 2, 4, 6 week visits, both groups showed an acceptable improvement in all nearly parameter., However, in comparison between the groups, there was no statistically significant differences (p>0.05). Complications such as injection pain and hyperpigmentation were seen in both treatment groups. Conclusion: The overall efficacy of 5-FU/TCN mixture was comparable with TCN alone. (Korean J Dermatol 2012;50(2):123~129)

6얼굴에 피부전이를 보인 심장의 혈관육종

저자 : 고재완 ( Jae Wan Go ) , 김신한 ( Shin Han Kim ) , 이상윤 ( Sang Yoon Lee ) , 노병인 ( Byung In Ro ) , 조한경 ( Han Kyoung Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 130-133 (4 pages)

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Angiosarcoma is a rare, aggressive vascular neoplasm of the endothelial cell origin. It is usually seen in male, elderly patients and generally has a poor prognosis due to its high potential for metastasis. They arise at various sites such as skin, soft tissue, heart and great vessels. However, the tumors have a predilection for skin and superficial soft tissue. Most angiosarcomas of the skin arise in the three clinical variant; primary angiosarcoma of the face and scalp in the elderly patients; following lymphedema, and post radiation or trauma. Although, this tumor tend to recur locally and metastasize to the viscera, especially in the lung, but cutaneous metastasis of angiosarcomas from the internal organ are uncommon. Herein, we report a patient with cutaneous metastasis from primary cardiac angiosarcoma in the right atrium. (Korean J Dermatol 2012;50(2):130~133)

7고령에서 발생한 지방모세포종

저자 : 송기훈 ( Ki Hoon Song ) , 전수영 ( Su Young Jeon ) , 고동엽 ( Dong Yeob Ko ) , 홍진우 ( Jin Woo Hong ) , 김기호 ( Ki Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 134-267 (134 pages)

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Lipoblastoma is a rare, benign tumor arising from embryonic fat tissues that continue to proliferate in the postnatal period. So, lipoblastoma occurs almost exclusively in infants and children younger than 3 years of age. Published reports showed that 70~90% of cases occur before the age of 3. Histopathologically, lipoblastoma, mimicking liposarcoma, was composed of well-defined lobulated fat tissue with multilobulated lipoblasts, undifferentiated mesenchymal cells, such as stellate or spindle cells and minimal myxoid stromas. The diagnosis of lipoblastoma is important because its management differs from that of lipoma and liposarcoma. To our knowledge, there are only a few reports of lipoblastoma in the Korean dermatologic literature. Herein, we present an interesting and atypical case of lipoblastoma in 68-year-old woman. (Korean J Dermatol 2012;50(2):134~137)

8Mesna에 의한 고정약진

저자 : 강연수 ( Yeon Soo Kang ) , 이지현 ( Ji Hyun Lee ) , 김시용 ( Si Yong Kim ) , 김경문 ( Gyong Moon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 138-141 (4 pages)

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A fixed drug eruption (FDE) is a cutaneous reaction caused by various drugs. Mesna is used to decrease urotoxic side effect of cyclophosphamide and there have been no previously reported cases in Korea for any adverse reactions to this drug. Herein, we report a case of a FDE caused by mesna. A 34-year-old woman presented with asymptomatic, brownish macules and patches on the face and back for the past 4 months. She had been treated for SLE with monthly pulses of intravenous cyclophosphamide and mesna for 6 months. She had experienced similar episodes after injection of mesna. The skin biopsy specimen taken from her showed vacuolar degeneration of the basal cell layer and perivascular lymphohistiocyte infiltration in the papillary dermis. We performed prick test, scratch patch test, and intradermal test with mesna and confirmed that a FDE was caused by this drug. (Korean J Dermatol 2012;50(2):138~141)

9항생제 반응검사 후 발생한 피부 림프모양 과다형성

저자 : 유창선 ( Chang Sun Yoo ) , 신수정 ( Soo Jung Shin ) , 길민성 ( Min Seong Kil ) , 박주혁 ( Ju Hyuk Park ) , 김철우 ( Chul Woo Kim ) , 김상석 ( Sang Seok Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 142-146 (5 pages)

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Cutaneous lymphoid hyperplasia (CLH, pseudolymphoma) refers to a heterogeneous group of benign reactive T- and/or B-cell lymphoproliferative diseases of the skin, that resemble cutaneous lymphoma both clinically and histologically. Despite the unknown causes of CLH development, various stimuli can induce CLH, such as medications, infections, insect bites, photosensitivity and foreign agents. To date, there has been no reported case of CLH development after an allergy skin test of antibiotics. Thus, we report a patient who developed CLH following an allergy skin test of antibiotics. He was a 21-year-old man who presented with 1.5×1.5 cm sized erythematous plaque with yellowish crusts on his right forearm that showed features of a CLH, based on histopathologic assessment. (Korean J Dermatol 2012;50(2):142~146)

10피부에서 발생한 골외성 Ewing 육종

저자 : 최재우 ( Jae Woo Choi ) , 권혁훈 ( Hyuck Hoon Kwon ) , 조성진 ( Seong Jin Jo ) , 서대헌 ( Dae Hun Suh )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 50권 2호 발행 연도 : 2012 페이지 : pp. 147-151 (5 pages)

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Extraskeletal Ewing`s sarcoma is an extremely rare malignant soft tissue tumor, which presents the exact same histopathologic features with Ewing`s sarcoma of bone. Tumor composed of small, blue, round cells with vesicular nuclei and scant cytoplasm is the characteristic histopathology of the disease. Extraskeletal Ewing`s sarcoma is known to occur usually in the deep soft tissues of the extremities. We report a case of 22-year-old boy with solitary extraskeletal Ewing`s sarcoma on his back without any evidence of bone involvement. The patient went through wide excision with meticulous lymph node dissection followed by chemotherapy. For the 15 months of follow up, there is not a sign of recurrence or metastasis observed. (Korean J Dermatol 2012;50(2):147~151)

12
주제별 간행물
간행물명 수록권호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 4호 ~ 32권 4호

KCI등재 SCOUPUS

대한피부과학회지
58권 6호 ~ 58권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 2호 ~ 46권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 5호 ~ 58권 5호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 4호 ~ 58권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 1호 ~ 46권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 3호 ~ 58권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 2호 ~ 32권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 2호 ~ 58권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호

프로그램북(구 초록집)
71권 1호 ~ 71권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 9호 ~ 57권 9호

프로그램북(구 초록집)
71권 2호 ~ 71권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 6호 ~ 31권 6호

프로그램북(구 초록집)
71권 2호 ~ 71권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 6호 ~ 31권 6호
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