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대한결핵 및 호흡기학회> Tuberculosis and Respiratory Diseases> 원저 : 1, 2병기 비소세포폐암의 예후에 대한 수술 전 양전자방출 컴퓨터 단층촬영기의 임상적 의의

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원저 : 1, 2병기 비소세포폐암의 예후에 대한 수술 전 양전자방출 컴퓨터 단층촬영기의 임상적 의의

Original Articles : Prognostic Value of Preoperative Positron Emission Tomography-Computed Tomography in Surgically Resected Stage I and II Non-Small Cell Lung Cancer

송성헌 ( Sung Heon Song ) , 손장원 ( Jang Won Sohn ) , 곽현정 ( Hyun Jung Kwak ) , 김사일 ( Sa Il Kim ) , 김상헌 ( Sang Heon Kim ) , 김태형 ( Tae Hyung Kim ) , 윤호주 ( Ho Joo Yoon ) , 신동호 ( Dong Ho Shin ) , 최윤영 ( Yoon Young Choi ) , 박성수 ( Sung Soo Park )
  • : 대한결핵 및 호흡기학회
  • : Tuberculosis and Respiratory Diseases 71권6호
  • : 연속간행물
  • : 2011년 12월
  • : 425-430(6pages)

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Background: High 2-[18F] fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) is a prognostic factor for poor survival in non-small cell lung cancer (NSCLC), especially in Stage I. We determined whether the high FDG uptake value of a primary tumor was associated with recurrence and death in patients with resected Stage I and Stage II NSCLC. Methods: We identified consecutive patients who underwent complete surgical resection for Stage I and II NSCLC between 2006 and 2009, who had preoperative PET-CT, and reviewed clinical records retrospectively. FDG uptake was measured as the maximal standardized uptake value (SUVmax) for body weight. Patients were divided into two groups based on SUVmax: (i) above or (ii) below the cut-off value (SUVmax=5.9) determined by a receiver operating characteristic (ROC) curve. Results: Of 57 patients who were enrolled consecutively, 32 (56%) had Stage I NSCLC and 25 (44%) had Stage II. The 5-year recurrence-free survival (RFS) for patients with high (≥5.9) and low (<5.9) SUVmax were 31% and 57%, respectively (p=0.014). The 5-year overall survival (OS) rates were 39% and 60%, respectively (p=0.029). In univariate analyses, SUVmax (p=0.014), T staging (p=0.025), and differentiation of tumor tissue (p=0.034) were significantly associated with RFS. But, multivariate analyses did not show that SUVmax was an independently significant factor for RFS (p=0.180). Conclusion: High FDG uptake on PET-CT is not an independent prognostic factor for poor outcomes (disease recurrence in patients with resected Stage I and II NSCLC).

UCI(KEPA)

I410-ECN-0102-2012-510-002630853

간행물정보

  • : 의약학분야  > 내과학
  • : KCI등재
  • : SCOPUS
  • : 계간
  • : 1738-3536
  • :
  • : 학술지
  • : 연속간행물
  • : 1954-2020
  • : 4945


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1종설 : 결핵 연구의 최근 성과들

저자 : 임재준 ( Jae Joon Yim )

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 395-399 (5 pages)

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Tuberculosis is one of the leading causes of mortality and morbidity worldwide. In 2010, there were 8.8 million (range, 8.5∼9.2 million) incident cases of TB, 1.1 million deaths from TB among HIV-negative people and an additional 0.35 million deaths from HIV-associated TB. Due to such health-related importance, tuberculosis is one of areas being actively researched. Many numbers of tuberculosis-related papers are being presented each year, and in this review, it summarizes contents of a few papers that had been selected among the papers presented from 2009 to early 2011.

2Original Articles : Awareness and Impact of COPD in Korea: An Epidemiologic Insight Survey

저자 : Yong Il Hwang , O Jung Kwon , Young Whan Kim , Young Sam Kim , Yong Bum Park , Myung Goo Lee , Dong Gyu Kim , Seung Hun Jang , Ki Suck Jung

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 400-407 (8 pages)

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Background: There were a few studies which were conducted to know about the behavior of the chronic obstructive pulmonary diseases (COPD) patients. The aims of this study was to explore the behaviour of COPD patients, such as awareness and impact of disease, the pathway of visiting doctors, and the treatment pattern and preference. Methods: A face-to-face interview of 300 subjects with COPD was conducted. Results: The most concerned symptom which made the respondents to visit the hospital was ``breathlessness`` (78%). Only 58% of them knew the exact diagnosis. Seventy-three percent of them visited the hospital ``once a month`` or ``once every 2 month``. They have made 12.8 prescheduled visits to the hospital in the past 1 year. Unscheduled visits and hospital stay figured to two in the past year. Only 11% of respondents felt they were currently in good health. ``Severe`` and ``very severe`` COPD patients perceived their health to be in a worse condition than ``mild`` and ``moderate`` COPD patients. When conditions worsened, 42% of patients were hospitalized. The most common prescription treatment was a fixed combination of inhaled corticosteroids and long-acting β2 agonists (48%), followed by a long acting anticholinergics (38%). Conclusion: Over forty percent of the patients didn`t know exactly about their condition. Most of them had a negative attitude toward their current health status. Doctors need to know more about COPD patients in terms of their attitude toward the disease, impact of the disease, interaction with healthcare professionals and treatment related problems.

3Original Articles : Utility of Routine Culture for Tuberculosis from Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in a Tuberculosis Endemic Country

저자 : Ji Young Hong , Ji Ye Jung , Young Ae Kang , Byung Hoon Park , Won Jai Jung , Su Hwan Lee , Song Yee Kim , Sang Kook Lee , Kyung Soo Chung , Seon Cheol Park , Eun Young Kim , Ju Eun Lim , Se Kyu Kim ,

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 408-416 (9 pages)

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Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9%), tuberculosis in 7 (8.1%), sarcoidosis in 7 (8.1%), asperogillosis in 2 (2.3%) and pneumoconiosis in 2 (2.3%) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5%) from 135 lymph node aspiration specimens and 2 (1.7%) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production.

4Original Articles : Association of p53 Expression with Metabolic Features of Stage I Non-Small Cell Lung Cancer

저자 : Shin Myung Kang , Won Jung Koh , Gee Young Suh , Man Pyo Chung , Joung Ho Han , Ho Joong Kim , O Jung Kwon , Sang Won Um

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 417-424 (8 pages)

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Background: Recent evidences have revealed metabolic functions of p53 in cancer cells; adaptation or survival to metabolic stress and metabolic shift toward oxidative phosphorylation. However, further studies in clinical setting are needed. We investigated whether p53 protein expression, as a surrogate marker for loss of p53 function, is associated with metabolic features of stage I non-small cell lung cancer (NSCLC), focusing on tumor necrosis and maximal standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography. Methods: Clinical information was obtained from retrospective review of medical records. p53 expression was assessed by immunohistochemical staining. Results: p53 protein expression was detected in 112 (46%) of 241 NSCLC cases included in this study. p53 expression was independently associated with the presence of necrosis (odds ratio [OR], 2.316; 95% confidence interval [CI], 1.215∼4.416; p=0.011). Non-adenocarcinoma histology (OR, 8.049; 95% CI, 4.072∼15.911; p<0.001) and poorly differentiation (OR, 6.474; 95% CI, 2.998∼13.979; p<0.001) were also independently associated with the presence of necrosis. However, p53 expression was not a significant factor for SUVmax. Conclusion: p53 protein expression is independently associated with the presence of necrosis, but not SUVmax.

5원저 : 1, 2병기 비소세포폐암의 예후에 대한 수술 전 양전자방출 컴퓨터 단층촬영기의 임상적 의의

저자 : 송성헌 ( Sung Heon Song ) , 손장원 ( Jang Won Sohn ) , 곽현정 ( Hyun Jung Kwak ) , 김사일 ( Sa Il Kim ) , 김상헌 ( Sang Heon Kim ) , 김태형 ( Tae Hyung Kim ) , 윤호주 ( Ho Joo Yoon ) , 신동호 ( Dong Ho Shin ) , 최윤영 ( Yoon Young Choi ) , 박성수 ( Sung Soo Park )

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 425-430 (6 pages)

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Background: High 2-[18F] fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) is a prognostic factor for poor survival in non-small cell lung cancer (NSCLC), especially in Stage I. We determined whether the high FDG uptake value of a primary tumor was associated with recurrence and death in patients with resected Stage I and Stage II NSCLC. Methods: We identified consecutive patients who underwent complete surgical resection for Stage I and II NSCLC between 2006 and 2009, who had preoperative PET-CT, and reviewed clinical records retrospectively. FDG uptake was measured as the maximal standardized uptake value (SUVmax) for body weight. Patients were divided into two groups based on SUVmax: (i) above or (ii) below the cut-off value (SUVmax=5.9) determined by a receiver operating characteristic (ROC) curve. Results: Of 57 patients who were enrolled consecutively, 32 (56%) had Stage I NSCLC and 25 (44%) had Stage II. The 5-year recurrence-free survival (RFS) for patients with high (≥5.9) and low (<5.9) SUVmax were 31% and 57%, respectively (p=0.014). The 5-year overall survival (OS) rates were 39% and 60%, respectively (p=0.029). In univariate analyses, SUVmax (p=0.014), T staging (p=0.025), and differentiation of tumor tissue (p=0.034) were significantly associated with RFS. But, multivariate analyses did not show that SUVmax was an independently significant factor for RFS (p=0.180). Conclusion: High FDG uptake on PET-CT is not an independent prognostic factor for poor outcomes (disease recurrence in patients with resected Stage I and II NSCLC).

6원저 : Impulse Oscillometry (IOS)를 이용한 무기분진 노출자에서의 기도폐쇄 연구

저자 : 이정오 ( Joung Oh Lee ) , 이유림 ( You Lim Lee ) , 최병순 ( Byung Soon Choi ) , 이홍기 ( Hong Ki Lee )

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 431-437 (7 pages)

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Background: We tried to examine the small airway diseases which can be found early, in workers exposed to inorganic dusts. This is measured in normal breath by using the impulse oscillometry (IOS). Methods: The Pulmonary function test (forced vital capacit [FVC], forced expiratory volume in one second [FEV1], forced expiratory flow between 25% and 75% of vital capacity [FEF25-75]), IOS resistance (Rrs at 5, 10, 15, 20, 25, 35 Hz) and reactance (Xrs at 5, 10, 15, 20, 25, 35 Hz) were measured for 454 workers. The subjects were classified into 173 workers of normal (38.1%) and 281 patients with pneumoconiosis (61.9%). Results: There were significant differences between normal and patients with FVC (3.82±0.61 vs. 3.53±0.56 L), FEV1 (2.67±0.63 vs. 2.35±0.48 L), and FEF25-75 (1.88±0.95 vs. 1.47±0.80 L/sec) between groups (p<0.05). And as for IOS, there was no significant difference in resistance (Rrs) (p>0.05), and there were significant differences between normal and patients with reactance (Xrs) 15 Hz (0.003±0.05 vs. -0.006±0.04 kPa/L/s), 20 Hz (0.043±0.05 vs. 0.031±0.04 kPa/L/s), and 35 Hz (0.141±0.05 vs. 0.131±0.05 kPa/L/s) between groups (p<0.05). Conclusion: We could find out that 15 Hz, 20 Hz, and 35 Hz values of reactance were significantly influenced by pneumoconiosis. When usefulness and reproducibility to carry out the IOS are considered, it is thought that in future work will be required to draw the reference values for normal Korean persons.

7원저 : 치료된 폐농양환자의 폐실질 병변의 분석

저자 : 이지연 ( Ji-yeon Lee ) , 구소미 ( So My Koo ) , 박경아 ( Kyong Ah Park ) , 서유리 ( Yu Ri Seo ) , 김세훈 ( Se Hun Kim ) , 김양기 ( Yang Ki Kim ) , 김기업 ( Ki Up Kim ) , 황정화 ( Jung Hwa Hwang ) , 어수택 ( Soo Taek Uh )

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 438-444 (7 pages)

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Background: Lung abscess is necrosis of the pulmonary parenchyma caused by microbial infection. At present, clinical outcomes after treatment are good. However, the pulmonary parenchymal changes on the chest computed tomography (CT) after treatment are not well known. We studied the changes of pulmonary parenchyma on plane chest radiography and chest CT in patients with lung abscess following the administration of antibiotics. Methods: We retrospectively reviewed 39 patients who had lung abscess with or without combined pneumonia from January 2006 to July 2010. We studied the therapeutic response in plane chest radiography of them at 1, 2, or more than 3 months following treatment. If any chest CT of them during the study period, we reviewed. Results: Mean age of the patients was about 61.3±11.2. Mean duration of antibiotics administration was about 36.7±26.8 days. After 3 months of following plane chest radiography, 10 patients (36%) showed without residual sequelae among 28 patients. Findings from other patients showed decrease in densities (11 patients, 39%), fibrostreaky sequelae (4 patients, 14%) and bullae (3 patients, 10%). After more than 2 months, chest CT was checked only in 7 patients. Among the 7 patients, 4 patients showed no residual lesion, 3 patients showed decreased densities on plane chest radiography. Chest CT revealed fibrostreaky densities in 2 patients, ground glass opacities in 3 patients, bullous formation in 1 patient, and cystic bronchiectasis in 1 patient. Conclusion: After more than 2 months following treatment for lung abscess even though there were no lesions on plane chest radiography, chest CT showed fibrostreaky or ground glass opacity.

8Case Reports : Asymptomatic Solitary Renal Metastasis Detected during Surveillance after Curative Surgery for Squamous Cell Carcinoma of Lung

저자 : Sung Heon Song , Young Jin Jun , Seung Sam Paik , Hyun Jung Kwak , , Sang Heon Kim , Tae Hyung Kim , Jang Won Sohn , Dong Ho Shin , Sung Soo Park , Ho Joo Yoon

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 445-449 (5 pages)

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Non small cell lung cancer (NSCLC) frequently metastasizes to brain, bone, liver, and adrenal glands. While an autopsy of NSCLC reveals some cases of metastasis to the kidney, clinical detection of renal metastases is extremely rare. Furthermore, metastases to the kidney usually present as multifocal or bilateral lesions and solitary renal metastases are usually suspected to be renal cell carcinoma. We now report a case of asymptomatic solitary renal metastasis from a primary squamous cell carcinoma, which was detected by routine surveillance with abdominal CT after curative surgery.

9증례 : 폐실질 내 침술 침의 비디오 흉강경 제거 1예

저자 : 정영규 ( Yeong Gyu Jeong ) , 이호성 ( Ho Sung Lee ) , 최재성 ( Jae Sung Choi ) , 나주옥 ( Joo Ock Na ) , 서기현 ( Ki Hyun Seo ) , 김용훈 ( Yong Hoon Kim ) , 이승진 ( Seung Jin Lee )

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 450-453 (4 pages)

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We report the case of a 32-year-old woman presenting with intermittent chest pain resulted from a migratory acupuncture needle. The patient received acupuncture treatment approximately 3 years prior to this presentation, for the treatment of chronic left shoulder and lumbar pain after delivery. Chest radiography revealed a retained needle in the lingular segmental area. Video-assisted thoracoscopy was then used to remove the migratory acupuncture needle attached between the lingular segmental lobe and the pericardial fat. The patient recovered without complications and was discharged home.

10증례 : 만성 림프구성 백혈병이 동반된 소세포폐암 1예

저자 : 송준석 ( June Seok Song ) , 이건화 ( Gun Hwa Lee ) , 이민규 ( Min Kyu Lee ) , 김웅준 ( Woong Jun Kim ) , 이승호 ( Seung Ho Lee ) , 김상헌 ( Sang Heon Kim ) , 김태형 ( Tae Hyung Kim ) , 윤호주 ( Ho Joo Yoon ) , 신동호 ( Dong Ho Shin ) , 박성수 ( Sung Soo Park ) , 최정혜 ( Jung Hye Choi )

발행기관 : 대한결핵 및 호흡기학회 간행물 : Tuberculosis and Respiratory Diseases 71권 6호 발행 연도 : 2011 페이지 : pp. 454-458 (5 pages)

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Chronic lymphocytic leukemia (CLL) is the most common type of leukemia occurring in Western nations. In CLL it is well known that the risk of a secondary malignancy is higher than in the normal population. But in Korea, CLL is a rare type of leukemia, so there have been only a few reported cases with a secondary malignancy. CLL is characterized by progressive defects in both cell-mediated and humoral immunity. It is known that defects in the immune system of patients with CLL contribute to the development of a secondary malignancy. We experienced a case of a 71-year-old man who suffered from a chronic cough and was diagnosed with small cell lung cancer coexisting with CLL. Until this case, there was no reported case in Korea of small cell lung cancer coexisting with CLL. We now report a case of small cell lung cancer coexisting with CLL and present a literature review.

12
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간행물명 수록권호

KCI등재

Allergy asthma & respiratory disease
8권 1호 ~ 8권 1호

KCI등재 SCI SCOUPUS

Journal of Neurogastroenterology and Motility
26권 1호 ~ 26권 1호

KCI등재 SCOUPUS

Intestinal research (Intest Res)
18권 1호 ~ 18권 1호

KCI등재 SCOUPUS

Clinical Endoscopy
53권 1호 ~ 53권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

Korean Journal of Medicine(구 대한내과학회지)
95권 1호 ~ 95권 1호

KCI등재 SCOUPUS

대한소화기학회지
75권 1호 ~ 75권 1호

KCI등재 SCOUPUS

Kidney Research and Clinical Practice(구 대한신장학회지)
38권 4호 ~ 38권 4호

KCI등재 SCOUPUS

Clinical and Molecular Hepatology(대한간학회지)
25권 4호 ~ 25권 4호

당뇨병(JKD)
20권 4호 ~ 20권 4호

KCI등재 SCI

The Korean Journal of Internal Medicine
35권 1호 ~ 35권 1호

KCI등재 SCI SCOUPUS

Diabetes and Metabolism Journal (DMJ)
43권 6호 ~ 43권 6호

대한결핵및호흡기학회 추계학술발표초록집
127권 0호 ~ 127권 0호

KCI등재 SCOUPUS

대한소화기학회지
74권 6호 ~ 74권 6호

KCI등재 SCI SCOUPUS

Endocrinology and Metabolism(구 대한내분비학회지)
34권 4호 ~ 34권 4호

대한당뇨병학회 학술발표논문집
2000권 0호 ~ 2000권 0호

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International Journal of Thyroidology
12권 2호 ~ 12권 2호
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