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대한소화기학회> 대한소화기학회지> 기획종설 : 소화기질환에서 줄기세포 치료의 현재와 미래 ; 소화기질환에서의 줄기세포를 이용한 임상연구와 줄기세포 치료의 미래

KCI등재SCOUPUS

기획종설 : 소화기질환에서 줄기세포 치료의 현재와 미래 ; 소화기질환에서의 줄기세포를 이용한 임상연구와 줄기세포 치료의 미래

Special Reviews : Stem Cell Therapy for Digestive Tract Diseases; Current State and Future Perspectives ; Clinical Trials with Stem Cells in Digestive Diseases and Future Perspectives

김태일 ( Tae Il Kim )
  • : 대한소화기학회
  • : 대한소화기학회지 58권3호
  • : 연속간행물
  • : 2011년 09월
  • : 139-143(5pages)
피인용수 : 30건

(자료제공: 네이버학술정보)

DOI


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Many techniques for isolation, expansion and handling of stem cells are being developed rapidly, and preclinical evidence has shown the possibility to use this technology for refractory diseases in the near future. Among refractory digestive diseases, Crohn`s disease and liver cirrhosis may be two main diseases where stem cell therapy can be applied for anti-inflammation and regeneration of tissue. Currently, with respect to these two diseases, clinical trials using hematopoietic stem cells and mesenchymal stem cells from bone marrow or adipose tissue have shown some evidence of clinical benefits to immune modulation, suppression of inflammation and regeneration of functional cells. However, for the development of practical stem cell therapy, we need more data on underlying mechanisms, effective subpopulation of stem cells and its sources, and effective parameters for monitoring and estimation. With technical advances, the research on embryonic and induced pluripotent stem cells will also contribute to the new therapeutic strategies for digestive regenerative medicine. In the future, a variety of stem cell therapies may be therapeutic options for refractory digestive diseases, but many technical challenges remain to be solved. (Korean J Gastroenterol 2011;58:139-143)

ECN


UCI

I410-ECN-0102-2012-350-002038017

간행물정보

  • : 의약학분야  > 내과학
  • : KCI 등재
  • : - / SCOPUS
  • : 월간
  • : 1598-9992
  • : 2233-6869
  • : 학술지
  • : 연속간행물
  • : 1968-2018
  • : 5410


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발행기관 최신논문
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1기획종설 : 소화기질환에서 줄기세포 치료의 현재와 미래 ; 질병치료제로서 줄기세포의 특성

저자 : 서검석 ( Geom Seog Seo )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 125-132 (8 pages)

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Stem cell research is a innovative technology that focuses on using undifferentiated cells able to self-renew through the asymmetrical or symmetrical divisions. Three types of stem cells have been studied in laboratory including embryonic stem cell, adult stem cells and induced pluripotent stem cells. Embryonic stem cells are pluripotent stem cells derived from the inner cell mass and it can give rise to any fetal or adult cell type. Adult stem cells are multipotent, have the ability to differentiate into a limited number of specialized cell types, and have been obtained from the bone marrow, umbilical cord blood, placenta and adipose tissue. Stem cell therapy is the most promising therapy for several degenerative and devastating diseases including digestive tract disease such as liver failure, inflammatory bowel disease, Celiac sprue, and pancreatitis. Further understanding of biological properties of stem cells will lead to safe and successful stem cell therapies. (Korean J Gastroenterol 2011;58:125-132)

2기획종설 : 소화기질환에서 줄기세포 치료의 현재와 미래 ; 소화기질환에서의 줄기세포 치료에 대한 전임상 연구

저자 : 전명신 ( Myung Shin Jeon ) , 홍순선 ( Soon Sun Hong )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 133-138 (6 pages)

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Adult stem cells are multipotent and self-renewing cells that contain several functions; i) migration and homing potential: stem cells can migrate to injured and inflamed tissues. ii) differentiation potential: stem cells which migrated to injured tissues can be differentiated into multiple cell types for repairing and regenerating the tissues. iii) immunomodulatory properties: stem cells, especially mesenchymal stem cells can suppress immune system such as inflammation. All those characteristics might be useful for the treatment of the digestive tract diseases which are complex and encompass a broad spectrum of different pathogenesis. Preclinical stem cell therapy showed some promising results, especially in liver failure, pancreatitis, sepsis, and inflammatory bowel disease. If we can understand more about the mechanism of stem cell action, stem cell therapy can become a promising alternative treatment for refractory digestive disease in the near future. In this review, we summarized current preclinical experiences in diseases of the digestive tract using stem cells. (Korean J Gastroenterol 2011;58:133-138)

3기획종설 : 소화기질환에서 줄기세포 치료의 현재와 미래 ; 소화기질환에서의 줄기세포를 이용한 임상연구와 줄기세포 치료의 미래

저자 : 김태일 ( Tae Il Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 139-143 (5 pages)

다운로드

(기관인증 필요)

초록보기

Many techniques for isolation, expansion and handling of stem cells are being developed rapidly, and preclinical evidence has shown the possibility to use this technology for refractory diseases in the near future. Among refractory digestive diseases, Crohn`s disease and liver cirrhosis may be two main diseases where stem cell therapy can be applied for anti-inflammation and regeneration of tissue. Currently, with respect to these two diseases, clinical trials using hematopoietic stem cells and mesenchymal stem cells from bone marrow or adipose tissue have shown some evidence of clinical benefits to immune modulation, suppression of inflammation and regeneration of functional cells. However, for the development of practical stem cell therapy, we need more data on underlying mechanisms, effective subpopulation of stem cells and its sources, and effective parameters for monitoring and estimation. With technical advances, the research on embryonic and induced pluripotent stem cells will also contribute to the new therapeutic strategies for digestive regenerative medicine. In the future, a variety of stem cell therapies may be therapeutic options for refractory digestive diseases, but many technical challenges remain to be solved. (Korean J Gastroenterol 2011;58:139-143)

4증례 : 십이지장 소유두의 신경내분비암종 1예

저자 : 하동우 ( Dong Woo Ha ) , 김광하 ( Gwang Ha Kim ) , 김동욱 ( Dong Uk Kim ) , 배민정 ( Min Jung Bae ) , 김보원 ( Bo Won Kim ) , 전혜경 ( Hye Kyung Jeon ) , 박도윤 ( Do Yun Park ) , 서형일 ( Hyung Il Seo )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 144-148 (5 pages)

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Neuroendocrine tumors are usually found in the ileum, appendix, rectum, colon and stomach. Ampullary neuroendocrine tumor is extremely rare and only a few cases of neuroendocrine carcinoma of the minor papilla have been reported. The preoperative diagnosis is very challenging because either asymptomatic or manifests as nonspecific abdominal pain. The tumor is relatively small and located at the deep mucosa and submucosa. Endoscopy with deep biopsy, endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography are good diagnostic tools. The best therapeutic choice is surgery. We report an unusual case of a 55-year-old woman who underwent endoscopy as part of a regular health checkup and was diagnosed a neuroendocrine carcinoma in the minor papilla, which was successfully resected by pancreaticoduodenectomy. (Korean J Gastroenterol 2011;58: 144-148)

5증례 : 간세포암 환자에서 간동맥화학색전술 후 발생한 간십이지장 누공

저자 : 박윤혜 ( Yoon Hea Park ) , 강세훈 ( Se Hun Kang ) , 김승업 ( Seung Up Kim ) , 김도영 ( Do Young Kim ) , 박준용 ( Jun Yong Park ) , 안상훈 ( Sang Hoon Ahn ) , 한광협 ( Kwang Hyub Han ) , 전재윤 ( Chae Yoon Chon )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 149-152 (4 pages)

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Transarterial chemoembolization (TACE) is recommended as one of the first line therapy for unresectable hepatocellular carcinoma (HCC). Rupture of HCC following TACE is a rare and potentially fatal complication. We report a case of hepaticoduodenal fistula with ruptured HCC and liver abscess complicated by TACE. A 52-year-old male was treated by TACE three times, followed by radiation therapy and systemic chemotherapy. 30 days after the last TACE, right upper quadrant pain of abdomen was developed. About 1 month later, computed tomography of abdomen showed ruptured HCC with debris containing liver abscess and hepaticoduodenal fistula. Esophagogastroduodenoscopy revealed hepaticoduodenal fistula and hepatic parenchyme covered with exudate. The patient was managed with supportive care, but the hepaticoduodenal fistula persisted. (Korean J Gastroenterol 2011;58:149-152)

6증례 : 복강내 담즙종으로 발현한 천공성 황색육아종성 담낭염 1예

저자 : 안연정 ( Yeon Jeong Ahn ) , 김태효 ( Tae Hyo Kim ) , 문성원 ( Sung Won Moon ) , 최수녕 ( Su Nyoung Choi ) , 김현진 ( Hyun Jin Kim ) , 정운태 ( Woon Tae Jung ) , 이옥재 ( Ok Jae Lee ) , 고경혁 ( Gyung Hyuck Ko )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 153-156 (4 pages)

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Xanthogranulomatous cholecystitis is an unusual inflammatory disease of the gallbladder characterized by severe proliferative fibrosis and the accumulation of lipid-laden macrophages in areas of destructive inflammation. Its macroscopic appearance may occasionally be confused with gallbladder carcinoma. We present a case of perforated xanthogranulomatous cholecystitis presenting as biloma. An 80-year-old woman was referred to our hospital with a 1-week history of abdominal pain and febrile sensation. Abdominal CT showed a biloma in the subhepatic area. The follow-up CT showed that the biloma increased in size. Therefore, ultrasonography-guided aspiration was performed. The aspirated fluid/serum bilirubin ratio was greater than 5, which was strongly suggestive of bile leakage complicated by perforated cholecystitis. She underwent a laparoscopic cholecystectomy with cyst aspiration and adhesiolysis. A histological diagnosis of perforated xanthogranulomatous cholecystitis was made. (Korean J Gastroenterol 2011;58:153-156)

7증례 : 비장 혈관종과 직장 정맥류를 보인 Klippel-Trenaunay Syndrome 1예

저자 : 최윤정 ( Youn Jung Choi ) , 지삼룡 ( Sam Ryong Jee ) , 박관식 ( Kwan Sik Park ) , 류충헌 ( Choong Heon Ryu ) , 서효림 ( Hyo Rim Seo ) , 하승인 ( Seoung In Ha ) , 이상헌 ( Sang Heon Lee ) , 옥경선 ( Kyung Sun Ok )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 157-161 (5 pages)

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Klippel - Trenaunay syndrome (KTS) is characterized by a cutaneous vascular nevus of the involved extremity, bone and soft tissue hypertrophy of the extremity and venous malformations. We present a case of KTS with splenic hemangiomas and rectal varices. A 29-year-old woman was referred for intermittent hematochezia for several years. She had history with a number of operations for cutaneous and soft tissue hamangiomas since the age of one year old and for increased circumference of her left thigh during the last few months. Abdominal CT revealed multiple hemangiomas in the spleen, fusiform aneurismal dilatation of the deep veins and soft tissue hemangiomas. There was no evidence of hepatosplenomegaly or liver cirrhosis. Colonoscopy revealed hemangiomatous involvement in the rectum. There were rectal varices without evidence of active bleeding. Upon venography of the left leg, we also found infiltrative dilated superficial veins in the subcutaneous tissue and aneurismal dilatation of the deep veins. The patient was finally diagnosed with KTS, and treated with oral iron supplementation only, which has been tolerable to date. Intervention or surgery is not required. When gastrointestinal varices or hemangiomatous mucosal changes are detected in a young patient without definite underlying cause, KTS should be considered. (Korean J Gastroenterol 2011;58:157-161)

8이 달의 영상 : 간세포암 환자에서 문맥 및 간정맥 색전술을 통해 간실질 위축을 유도한 후 시행된 우간절제술

저자 : 황신 ( Hwang Shin )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 162-165 (4 pages)

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9최신 연구 소개 : 췌관내 유두상 점액 종양의 형태학 유형은 예후와 관련이 있는가?

저자 : 배선윤 ( Sun Youn Bae ) , 이규택 ( Kyu Taek Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 58권 3호 발행 연도 : 2011 페이지 : pp. 166-167 (2 pages)

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췌관내 유두상 점액 종양(intraductal papillary mucinous neoplasms of the pancreas, IPMN)은 병리소견의 형태학 유형에 따라서 4가지, 즉 gastric, intestinal, pancreatobiliary, oncocytic으로 구분된다. 이런 형태적 구분이 임상양상과 예후에 어떤 관련이 있는 지에 대해 명확하지 않고, 보고에 따라 차이가 있었다. 이번 연구는 IPMN의 형태적 유형에 따라서 임상 및 병리적 유용성과 의의를 알아보고자 하였다. 수술을 시행하여 확진된 283명의 IPMN 환자들을 후향적으로 분석하였다. 이 중 139명(49%)이 gastric 형태로 가장 많았고, 101명(36%)이 intestinal 형태, 19명(7%)이 pancreatobiliary 형태, 24명(8%)이 oncocytic 형태였다. Pancreatobiliary 형태의 경우 주로 여성과 고령에서 발생하였고, oncocytic 형태는 비교적 젊은 연령에서 발생하였다. Pancreatobiliary 형태와 oncocytic 형태는 내벽결절(mural nodule) 을 동반한 경우가 많았다. Gastric 형태는 조직소견에서 가장 양호한 소견을 보여 대부분 선종이었으나, intestinal 형태의 경우 비침습적인 췌관내 유두상 점액암과 관련이 높았고 pancreatobiliary 형태는 침습적인 선암과 관련이 높았다. Gastric형태는 분지 췌관을 침범하는 IPMN인 경우가 많았던 반면에, intestinal 형태는 주췌관을 침범하는 IPMN인 경우가 많았다. 형태적 유형은 환자의 예후와 의미 있는 연관성을 보였는데, gastric형태가 가장 좋은 예후(5년 생존율 94%)를 보였고 intestinal 형태(5년 생존율 89%)와 oncocytic 형태(5년 생존율 84%)가 중간 정도의 예후를 보인 반면에, pancreatobiliary 형태는 5년 생존율이 52%로 가장 나쁜 예후를 보였다. 이런 결과는 IPMN의 예후를 예측하는데 있어서 형태적 유형도 병기와 더불어 독립적인 예측인자로 사용할 수 있음을 보여 주었다.

1
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