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간세포성장인자와 신장질환

Review Article : Hepatocyte Growth Factor and Kidney Disease

박준성 ( Joon Sung Park ) , 김근호 ( Gheun Ho Kim )
  • : 대한신장학회
  • : Kidney Research and Clinical Practice(구 대한신장학회지) 30권4호
  • : 연속간행물
  • : 2011년 07월
  • : 359-367(9pages)
피인용수 : 63건

(자료제공: 네이버학술정보)

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Hepatocyte growth factor (HGF), also known as scatter factor, was identified during the experimental attempts to explore a phantom factor acting as a trigger for liver regeneration after partial hepatecotmy. HGF is synthesized and secreted as a single-chain inert precursor by cells of mesodermal origin, and extracellularly processed to the two-chain functional heterodimer by proteolytic cleavage at a specific site. The binding of HGF to the c-MET, the HGF receptor, induces activation of tyrosine kinase and autophosphorylation of tyrosine residues. c-MET activation propagates an intricate system of signaling pathways that controls a range of cellular processes as diverse as cell proliferation, differentiation, transformation and apoptosis. In the aspect of kidney, the HGF/c-MET signaling pathway plays important roles in renal development and in the maintenance of normal adult kidney structure and function. In various injury and disease models, HGF has been reported to promote cell survival, tissue regeneration, and fibrosis suppression. Neutralization of HGF by the antibody may accelerate renal failure or fibrosis while HGF administration may lead to remarkable amelioration. Thus, HGF is not only the endogenous safeguard protecting normal tissues against the fibrotic process after injury, but also a therapeutic option to prevent organ failure. If insufficient production of HGF is causative for renal fibrosis, administration of recombinant human HGF protein or HGF gene therapy may improve renal fibrosis and dysfunction. HGF gene therapy requires appropriate delivery systems, and biodegradable polyester amine based on glycerol dimethacrylate and polyethylenimine is being tested for the HGF gene carrier in experimental models.

UCI(KEPA)

I410-ECN-0102-2012-360-002048822

간행물정보

  • : 의약학분야  > 내과학
  • : KCI등재
  • : SCOPUS
  • : 계간
  • : 2211-9132
  • :
  • : 학술지
  • : 연속간행물
  • : 1982-2019
  • : 3733


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1ABO 혈액형 부적합 신장이식

저자 : 양재석 ( Jae Seok Yang )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 355-358 (4 pages)

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2간세포성장인자와 신장질환

저자 : 박준성 ( Joon Sung Park ) , 김근호 ( Gheun Ho Kim )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 359-367 (9 pages)

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Hepatocyte growth factor (HGF), also known as scatter factor, was identified during the experimental attempts to explore a phantom factor acting as a trigger for liver regeneration after partial hepatecotmy. HGF is synthesized and secreted as a single-chain inert precursor by cells of mesodermal origin, and extracellularly processed to the two-chain functional heterodimer by proteolytic cleavage at a specific site. The binding of HGF to the c-MET, the HGF receptor, induces activation of tyrosine kinase and autophosphorylation of tyrosine residues. c-MET activation propagates an intricate system of signaling pathways that controls a range of cellular processes as diverse as cell proliferation, differentiation, transformation and apoptosis. In the aspect of kidney, the HGF/c-MET signaling pathway plays important roles in renal development and in the maintenance of normal adult kidney structure and function. In various injury and disease models, HGF has been reported to promote cell survival, tissue regeneration, and fibrosis suppression. Neutralization of HGF by the antibody may accelerate renal failure or fibrosis while HGF administration may lead to remarkable amelioration. Thus, HGF is not only the endogenous safeguard protecting normal tissues against the fibrotic process after injury, but also a therapeutic option to prevent organ failure. If insufficient production of HGF is causative for renal fibrosis, administration of recombinant human HGF protein or HGF gene therapy may improve renal fibrosis and dysfunction. HGF gene therapy requires appropriate delivery systems, and biodegradable polyester amine based on glycerol dimethacrylate and polyethylenimine is being tested for the HGF gene carrier in experimental models.

3무증상적 요이상을 보인 성인 환자의 임상 경과

저자 : 최고 ( Go Choi ) , 황은아 ( Eun Ah Hwang ) , 여상목 ( Sang Mok Yeou ) , 백진혁 ( Jin Hyuk Paek ) , 박성배 ( Sung Bae Park ) , 한승엽 ( Seung Yeup Han ) , 김현철 ( Hyun Chul Kim ) , 최미선 ( Mi Sun Choe )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 368-376 (9 pages)

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Purpose: Urinalysis is one of the best methods for early detection of renal disease and recent wide- spread use of mass screening led to increasing prevalence of asymptomatic urinary abnormalities. Usually, primary chronic glomerulonephritis first presents with asymptomatic urinary abnormalities and chronic glomerulonephritis commonly causes end-stage renal disease. However, clinical outcome of asymptomatic urinary abnormalities in adults is not well known. Methods: Between Jan 1995 to Aug 2009, 333 patients with asymptomatic urinary abnormalities who underwent percutaneous renal biopsy were enrolled. A retrospective study was performed to clarify the prognostic factors and the long-term renal outcome of this disease. Results: According to clinical manifestation, there were 79 (23.7%) of isolated microscopic hematuria, 30 (9.0%) of isolated proteinuria and 224 (67.3%) of mixed hematuria and proteinuria. The patients were significantly younger in case with microscopic hematuria. Group with microscopic hematuria had significantly shorter follow up period (p=0.013). In pathologic diagnosis, IgA nephropathy was most common with 244 patients (73.3%). The proteinuria group and mixed group showed significantly higher rate of progression to chronic renal failure than the microscopic hematuria group (p=0.015). The group that 24-hour proteinuria was more than 0.5 g/day showed significantly higher progression rate to chronic renal failure (p<0.000). Using univariate regression analysis, 3 risk factors for progression to chronic renal failure were identified: age, serum creatinine, 24-hour total urine protein. In multivariate regression analysis, only 24-hour proteinuria was the independent prognostic factor for progression to chronic renal failure. Conclusion: IgA nephropathy is the most common cause of asymptomatic urinary abnormalities in adults. The group of proteinuria has higher progression rate to chronic renal failure than other groups. Over 0.5 gm of 24-hour proteinuria is a significant risk factor for progression to chronic renal failure in multivariate regression analysis.

4투석 중인 말기신부전 환자에서 관동맥 우회로술과 관동맥 중재술의 장기 성적 비교

저자 : 선휘경 ( Hui Kyoung Sun ) , 김나경 ( Na Kyoung Kim ) , 조유정 ( Yu Jung Cho ) , 강승대 ( Seung Dae Kang ) , 김태완 ( Tae Wan Kim ) , 한금현 ( Kum Hyun Han ) , 도준형 ( Joon Hyung Doh ) , 이성윤 ( Sung Yun Lee ) , 김창영 ( Chang Young Kim ) , 장우익 ( Woo Ik Chang ) , 한상엽 ( Sang Youb H

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 377-385 (9 pages)

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Purpose: Coronary artery disease is the main cause of morbidity and mortality in dialysis patients. Some observational studies proposed that coronary artery bypass graft (CABG) might provide higher survival benefit than percutaneous coronary intervention (PCI) in dialysis patients. There were not many studies of the comparison between the methods of coronary artery reperfusion therapy. Therefore, we compared the long term survival between PCI and CABG groups in dialysis patients. Methods: We selected 104 patients with end stage renal disease (ESRD) who had PCI (N=75) or CABG (N=29) in Ilsan-Paik Hospital from December 1999 to February 2010. We collected data from medical records and performed a retrospective analysis in ESRD patients hospitalized for the first coronary revascularization procedure. Results: There was no difference in the basic characteristics between the two groups. However, the frequency of more than 3-vessel lesions or less than 30% ejection fraction was higher in the group of CABG than that of PCI. One and three-year survival rates were higher in the PCI group than those in the CABG group. However, there was no difference in the 5 year survival rate between the groups. In subgroup analysis for severe patients with 3-vessel coronary diseases or less than 30% of ejection fraction, there were no statistical differences in the 1, 3 and 5 year survival rates between the groups. In subgroup analysis for the patients maintaining dialysis more than three months, 1, 3, and 5 year survival rates were not statistically different. Conclusion: In ESRD and dialysis patients, there was no difference in the long-term survival between PCI and CABG.

5Rituximab와 혈장교환을 사용한 ABO 혈액형 부적합 생체 신장이식: 단일 기관의 경험

저자 : 유훈 ( Hoon Yu ) , 김윤지 ( Yoon Ji Kim ) , 권석운 ( Seog Woon Kwon ) , 한덕종 ( Duck Jong Han ) , 박재범 ( Jae Berm Park ) , 박정식 ( Jung Sik Park ) , 정주희 ( Joo Hee Jung ) , 박수길 ( Su Kil Park )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 386-393 (8 pages)

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Purpose: ABO incompatibility had long been an obstacle in kidney transplantation. However, recent reports showed excellent outcomes. In this study, we evaluated the outcomes of ABO incompatible kidney transplantation with preconditioning protocol using rituximab and plasmapheresis. Methods: The recipients who had an ABO-incompatible donor and underwent living donor kidney transplantation were enrolled. Preconditioning protocol was pretransplant single dose rituximab with plasmapheresis at pretransplantation 7-10 days. Immune suppression regimen consisted of tacrolimus, mycophenolate mofetil and steroid. Anti-A or anti-B antibody titer was monitored during preconditioning and post transplantation period. Results: 37 patients underwent living donor ABO incompatible kidney transplantation. Median pre-treatment antibody titer was 1:64 and pre transplant antibody titer after 1-6 times of plasmapheresis was 1:2. Median follow-up duration was 332 days (range 156-681). One episode of acute T cell mediated rejection was observed. Mean serum creatinine at 2 weeks was 1.00±0.27 mg/dL and at 24 weeks was 1.21±0.37 mg/dL. Conclusion: ABO incompatible kidney transplantation with rituximab and plasmapheresis can be safely performed. It is therefore a valuable option for expanding donor pool and should be actively performed in Korea.

6횡문근융해증에 의한 급성 신손상 환자에서 발생한 고혈압성가역적후두부뇌병증 증후군 1예

저자 : 김우정 ( Woo Jeung Kim ) , 박승교 ( Seong Kyo Park ) , 최훈영 ( Hoon Young Choi ) , 하성규 ( Sung Kyu Ha ) , 박형천 ( Hyeong Cheon Park )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 394-398 (5 pages)

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Posterior reversible encephalopathy syndrome (PRES) is characterized by altered mental status, headache, vomiting, visual loss, seizure and reversible posterior subcortical white matter and cortex edema in brain image studies. It is often associated with malignant hypertension and immunosuppression. We present a 30-year-old male with PRES. He was admitted to our hospital with rhabdomyolysis and acute kidney injury (AKI). During the hospital course, he developed acute malignant hypertension accompanied by visual loss and generalized seizure. Brain MRI demonstrated increased signal intensity with gyral swelling in cerebellar hemisphere, parieto-occipital cortex, and subcortical white matter area. Following aggressive blood pressure control and hemodialysis the patient recovered fully without any neurologic or visual complications. We report a case of PRES associated with AKI due to rhabdomyolysis.

7급성신부전증과 간문맥 혈전증으로 발현한 미세변화신증후군 1예

저자 : 권희선 ( Hee Sun Kwon ) , 신아영 ( Ah Young Shin ) , 이화영 ( Hwa Young Lee ) , 조성연 ( Sung Yeon Cho ) , 김민주 ( Min Ju Kim ) , 윤유선 ( Yu Seon Yun ) , 김현경 ( Hyun Gyung Kim ) , 김영수 ( Young Soo Kim ) , 최영진 ( Yeong Jin Choi ) , 김영옥 ( Young Ok Kim )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 399-403 (5 pages)

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Patients with the nephrotic syndrome are at risk of developing thromboembolic complications. Much evidence suggests that a hypercoagulable state exists in the setting of the nephrotic syndrome, but the exact mechanisms are poorly understood. The nephrotic syndrome associated with portal vein thrombosis is relatively uncommon. We experienced a case of minimal change nephrotic syndrome presented as portal vein thrombosis and acute renal failure. On renal biopsy, electron microscopic examination reveals diffuse foot process effacement. Treatment with corticosteroid and anticoagulation resulted in complete remission of proteinuria.

8흉선종 절제술 후 발생한 미세변화병 1예

저자 : 도화미 ( Fa Mee Doh ) , 장선정 ( Seon Jung Jang ) , 구향모 ( Hyang Mo Koo ) , 김은진 ( Eun Jin Kim ) , 신혜선 ( Hye Sun Shin ) , 한승혁 ( Seung Hyeok Han ) , 강신욱 ( Shin Wook Kang ) , 최규헌 ( Kyu Hun Choi ) , 유태현 ( Tae Hyun Yoo )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 404-408 (5 pages)

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We report a case of patient with malignant thymoma, who developed nephrotic syndrome several years after thymectomy. This 38-year-old man was diagnosed as myasthenia gravis and malignant thymoma and underwent thymectomy in 2004. Tumor resection and systemic chemotherapy were performed after recurrence in pleura in 2006. He also took pyridostigmine to control his symptoms of myasthenia gravis after thymectomy. Four years later, even though there was no evidence of recurrence of thymoma, he developed a nephrotic syndrome and was diagnosed as a minimal change disease on renal biopsy. After pulse therapy with methylprednisolone followed by oral administration of prednisolone therapy, nephrotic syndrome was improved.

9면역억제제를 복용 중인 막성신병증 환자에서 발생한 성인형 스틸병 1예

저자 : 강효진 ( Hyo Jin Kang ) , 김준모 ( Joon Mo Kim ) , 박소영 ( So Young Park ) , 이상엽 ( Sang Yeob Lee ) , 김기현 ( Ki Hyun Kim ) , 김성은 ( Seong Eun Kim ) , 손영기 ( Young Ki Son ) , 안원석 ( Won Suk An )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 409-413 (5 pages)

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Adult onset Still`s disease (AOSD) is a rare systemic inflammatory disease characterized by high spiking fever, leukocytosis, high serum ferritin, salmon-colored rash, arthritis, lymphadenopathy, and hepatosplenomegaly. The etiology of AOSD is obscure. AOSD is diagnosed after exclusion of infection, malignancy and other connective tissue diseases. A 53-year-old female patient with membranous nephropathy was admitted with high fever and leukocytosis. She was taking immunosuppressive agents with low dose steroid and cyclosporine to control of proteinuria caused by membranous nephropathy. She was initially treated with antibiotics, antiviral agent and antifungal agent to control of hidden infection. High spiking fever was sustained for 2 weeks and controlled after hydrocortisone treatment. AOSD was diagnosed according to the criteria of Yamaguchi. It should be considered that AOSD is a cause of high fever in patients treated with immunosuppressive agents.

10혈액투석 환자에서 경요도방광종양절제술 후 발생한 경요도절제후 증후군 2예

저자 : 정은호 ( Eun Ho Jeong ) , 김은나 ( Eun Na Kim ) , 왕희배 ( Hee Bae Wang ) , 김태호 ( Tae Ho Kim ) , 박정석 ( Jeong Suk Park ) , 김태형 ( Tae Hyung Kim ) , 김진우 ( Jin Ou Kim ) , 서상렬 ( Sang Yeol Suh ) , 성원섭 ( Won Sub Seong )

발행기관 : 대한신장학회 간행물 : Kidney Research and Clinical Practice(구 대한신장학회지) 30권 4호 발행 연도 : 2011 페이지 : pp. 414-418 (5 pages)

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Transurethral resection syndrome (TURS) is one of the complications of endoscopic transurethral operation with irrigation fluid. TURS comprehensively refer to several clinical symptoms and signs caused by intravascular absorbtion of irrigation fluid, hypertension, bradycardia, arrhythmia, respiratory distress, hypotension, confusion, blindness, seizure, coma, hyponatremia, and hypoosmolarity. TURS is mainly known as the complication of the transurethral resection of prostate (TURP), and rarely found in the procedures such as transurethral resection of bladder tumor (TUR-BT), hysteroscopy, cystoscopy, and arthroscopy. Only a few cases of TURS after TUR-BT have been reported. The patients on maintenance hemodialysis were restricted in the amount of water intake for volume control. They were susceptible to the absorption of irrigation fluid during TUR-BT since they had anuria. We hereby report the 2 cases maintenance hemodialysis patients who were led to TURS after TUR-BT.

12
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Allergy asthma & respiratory disease
8권 1호 ~ 8권 1호

KCI등재 SCI SCOUPUS

Journal of Neurogastroenterology and Motility
26권 1호 ~ 26권 1호

KCI등재 SCOUPUS

Intestinal research (Intest Res)
18권 1호 ~ 18권 1호

KCI등재 SCOUPUS

Clinical Endoscopy
53권 1호 ~ 53권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

KCI등재 SCI SCOUPUS

Gut and Liver
14권 1호 ~ 14권 1호

Korean Journal of Medicine(구 대한내과학회지)
95권 1호 ~ 95권 1호

KCI등재 SCOUPUS

대한소화기학회지
75권 1호 ~ 75권 1호

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Kidney Research and Clinical Practice(구 대한신장학회지)
38권 4호 ~ 38권 4호

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Clinical and Molecular Hepatology(대한간학회지)
25권 4호 ~ 25권 4호

당뇨병(JKD)
20권 4호 ~ 20권 4호

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The Korean Journal of Internal Medicine
35권 1호 ~ 35권 1호

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Diabetes and Metabolism Journal (DMJ)
43권 6호 ~ 43권 6호

대한결핵및호흡기학회 추계학술발표초록집
127권 0호 ~ 127권 0호

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대한소화기학회지
74권 6호 ~ 74권 6호

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Endocrinology and Metabolism(구 대한내분비학회지)
34권 4호 ~ 34권 4호

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2000권 0호 ~ 2000권 0호

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International Journal of Thyroidology
12권 2호 ~ 12권 2호
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