Gross-to-net ratio is the important factor determining size of the building. However it was determined as the empirical method without the exact basis in the existing planning. This paper proposes more accurate methods for determining the gross-to-net ratio of architectural planning in general hospital. This paper analyzes the difference of gross-to-net ratio according to the various conditions and presents the elements of influencing on gross-to-net ratio. These elements is evaluated by applying in the typical hospital case. In conclusion, gross-to-net ratio is influenced by the accuracy of the space program, form type of the space and correspondence potential about the internal variation. In addition, This study has proved that empirical approach is a standard of minimum area.