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한국피부장벽학회> 한국피부장벽학회지> 학술대회 : 종설 ; 아토피피부염의 피부 장벽학적 이해와 통합치료

학술대회 : 종설 ; 아토피피부염의 피부 장벽학적 이해와 통합치료

김현정 ( Hyun Jung Kim ) , Se Kyoo Jeong , Hye Young Yum , Seung Hun Lee
  • : 한국피부장벽학회
  • : 한국피부장벽학회지 12권1호
  • : 연속간행물
  • : 2010년 10월
  • : 67-78(12pages)

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UCI(KEPA)

I410-ECN-0102-2012-510-001779197

간행물정보

  • : 의약학분야  > 피부과학
  • :
  • :
  • : 반년간
  • : 1229-4934
  • :
  • : 학술지
  • : 연속간행물
  • : 1999-2019
  • : 557


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1Inhibition of Atopic Dermatitis by Topical Application of SNARE Complex Inhibitor in NC/Nga Mice

저자 : 황재성 ( Jae Sung Hwang ) , Hyo Young Kim , Eun Ja Choi , Jung Hyun Goo , Dae Hyuk Kweon , Dae Kyun Chung

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 9-15 (7 pages)

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Granule exocytosis in mast cells is controlled by membrane-membrane fusion proteins termed SNAREs (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors). SNARE protein mediate membrane fusion between synaptic vesicle and presynaptic membrane, resulting in mast cell fusion and releasing histamine, serotonin, and other inflammatory mediators. Blocking SNARE assembly process might exert the inhibition of mast cell fusion and releasing inflammatory mediators. In this study we examined the effects of SNARE inhibitor derived from plant extract on atopic dermatitis model using NC/Nga mice. Topical application of SNARE inhibitor reduced 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice in terms of several biological markers. Serum IgE level was reduced significantly after 4 weeks treatment. Mast cell number was also reduced significantly by inhibitor treatment. Number of scratching was reduced slightly but there was no significance. Our results raise the possibility that SNARE folding inhibitors from natural sources might used for treatment of atopic dermatitis.

2Genotoxicity and Skin Penetration of Silver Nanoparticles in Hairless Mice After Dermal Exposure

저자 : 이병무 ( Byung Mu Lee ) , Dong Eun Jang , Eun Hwa Kwak , Seung Jun Kwack , Jea Yeon Jung , Mi Jung Kwon , Eun Young Han , Il Young Ahn , Jung Yun Bae , Seong Kwang Lim , Dong Hyun Kim , Eun Kyung Choi

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 16-17 (2 pages)

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Silver nanoparticles have been used for a variety of consumer products which may directly contact the skin. This study aims to investigate genotoxicity in vitro and skin penetration of silver (Ag) nanoparticles of varying sizes in male SKH1-hairless mice. Dorsal skin of six-week-old hairless mice was treated with 5-10, 100, and 160 nm silver nanoparticles at 1, 10, and 100 mg/kg body weight for 1 month. After dermal exposure of size-dependent silver nanoparticles for 4weeks, blood, urine and organ distribution of silver nanoparticles was measured by ICP-MS (inductively coupled plasma mass spectrometry) analysis. In case of 5-10nm silver nanoparticle treatment, silver concentrations were increased in a dosedependent manner at all measured organs and body fluid. Silver nanoparticles were absorbed through the skin and distributed in the body. The concentrations of silver nanoparticles were highest in the liver among various organs measured and followed by kidney, heart, and brain (liver>kidney>heart> urine>brain>blood in order). In 100 nm and 160 nm silver nanoparticles treatment groups, silver concentrations in the organs and body fluids were also increased in a dose-dependent manner. Blood biochemistry showed that GOT (glutamic oxaloacetic transaminase), ALP (alkaline phosphatase), TG (triglyceride), and BUN (blood urea nitrogen) values were significantly increased in the sera from high-dose group (5-10nm). Mutagenicity tests showed that Ag nanoparticles alone are not genotoxic, but genotoxic in combination of Fe++ or Cu++. These results suggest that silver nanoparticles, dependent on particle size and concenration, are able to be absorbed through the skin and may produce hepatotoxicity in vivo and genotoxicity in the presence of metal ions such as Fe++ or Cu++

3Paired-Like Homeodomain Transcription Factor 2c (PITX2c) and Brn2: Transcription Factors Regulating Keratinocyte Differentiation

저자 : 이영 ( Young Lee ) , Ge Shi , Kyung Cheol Sohn , Chang Deok Kim

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 18-24 (7 pages)

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Terminal differentiation of skin keratinocytes is a vertically directed multi-step process that is tightly controlled by the sequential expression of a variety of genes. In this study, we investigated the functional role of Paired-like homeodomain transcription factor 2 (PITX2) and POU domain-containing transcription factor Brn2 in keratinocyte differentiation. RTPCR analysis showed that PITX2c and Brn2 both were predominantly expressed in a differentiation-dependent manner. The RP-PCR data was consistent with the immunohistochemical staining. When PITX2c and Brn2 were overexpressed in cultured keratinocytes by a recombinant adenovirus, the differentiation markers such as involucrin and loricrin were significantly increased at both mRNA and protein levels. In addition, PITX2c overexpression led to the decrease of cell growth, concomitantly with the upregulation of cell cycle-related genes p21. These results suggest that PITX2c and Brn2 have a role for promoting the differentiation of epidermal keratinocytes.

4학술대회 : 종설 ; 피부장벽과 접촉피부염 (초)

저자 : 이준영

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 25-25 (1 pages)

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5Human Skin Dermis and Epidermal Barrier Function in Aging Skin

저자 : Tai Hao Quan

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 29-30 (2 pages)

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6Stress and the Epidermis

저자 : Theodora Mauro

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 31-31 (1 pages)

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7Bricks and Mortar: Two Compartment System

저자 : 홍승필

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 35-40 (6 pages)

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피부장벽의 구조는 'two compartment model'로 설명하며, 이를 벽돌담에 비유하여 “bricks and mortar model”이라고도 한다. 단백질로 되어 있는 각질세포는 각질층의 구조적 안정성을 유지해주는 벽돌(bricks)과 비유될 수 있고, 각질세포 사이의 지질층은 각질세포 사이 공간을 채워주는 시멘트 회반죽(mortar)의 역할을 한다고 설명한다. 약 30년 전 처음 제시된 이래로 새로운 사실들이 많이 밝혀졌지만 현재까지 각질층의 피부장벽의 구조를 가장 쉽고 정확하게 이해할 수 있는 이론임에는 틀림이 없다. 현재까지 알려진 Bricks & mortar 이론의 간략한 개념과 세포사이 지질층을 구성하는 세라마이드, 콜레스테롤, 자유지방산 같은 주요 지질성분, 각질세포의 구성 및 각질형성세포의 분화를 통한 각질세포막의 형성에 대해서 중요 내용들 위주로 기술하였다.

8Anti-microbial Peptides (AMPs) in Skin Barrier

저자 : 정세규 , 김현정 , 이승헌

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 41-50 (10 pages)

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As the name implies, role of anti-microbial peptides (AMPs) has been mainly considered as providing anti-microbial defense against exogenous infections of bacteria, fungi and virus. Through the extensive researches, however, the roles of AMPs are continuously extending; including the regulation of adaptive immune responses and inflammatory responses. In animals, AMPs expression is generally localized in epithelial tissues, such as skin and gastrointestinal tracts. In skin, along with the acid mantle and anti-microbial lipids, epidermal AMPs are responsible for the skin`s anti-microbial barrier function. Recently reported studies have suggested that the AMPs are closely interrelated with other barrier functions exerted by skin, including epidermal permeability barrier function and immune barrier function. While it is still controversial, down-regulated expression of AMPs in atopic dermatitis is, at least in part, responsible for the increased susceptibility of AD skins against secondary infections, usually observed as S. aureus infection. In this review, the brief explanation of AMPs in terms of their structure, function, and regulation of expressions are discussed. In addition, role of AMPs in skin diseases is also explored and the effects of Defensamide™, a recently developed small molecule compound that stimulates the epidermal expression of AMPs, on oxazolone-induced atopic dermatitis animal model is provided. Results of clinical studies performed with Defensamide™ are also introduced.

9Epidermal Calcium Gradient and the Skin Barrier

저자 : 김병수 ( Byung Soo Kim )

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 51-56 (6 pages)

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Human epidermis displays a characteristic calcium gradient, with low calcium levels in the basal and spinous layers, but increased progressively towards the outer stratum granulosum. The distribution pattern of ionic calcium correlates with growth and differentiation of keratinocytes, as low extracellular calcium concentrations stimulate the growth of keratinocytes with high proliferation rate, and a high extracellular calcium levels induce differentiation and stratification. However, such a gradient is not observed in skin abnormalities related to the formation of abnormal barrier function, such as psoriasis. Also, acute disruption of the epidermal permeability barrier causes an influx of water into stratum corneum and immediate loss of calcium gradient. Subsequently, this depletion of calcium gradient regulates lamellar body exocytosis, and the restoration appears in parallel with barrier recovery. The regulation of calcium in skin is therefore requisite to maintain a normal skin barrier function and to avoid dry skin symptoms. Furthermore, extracellular calcium ions are important for cell-cell adhesion and epidermal differentiation.

10Skin Barrier and Moisturizer

저자 : 박하나 ( Ha Na Bak )

발행기관 : 한국피부장벽학회 간행물 : 한국피부장벽학회지 12권 1호 발행 연도 : 2010 페이지 : pp. 59-66 (8 pages)

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Moisturizers are substances designed to improve and maintain the skin barrier. They could include active ingredients that minimize dehydration, photoprotect, and provide antioxidant properties. Moisturizers are based on occlusive substances such as petrolatum and dimethicone, and humectant substances, such as glycerin, with a variety of sunscreens and botanicals for added functionality. Moisturizers prevent and treat dry skin, protect sensitive skin, improve skin tone and texture. Also, moisturizers can serve as important adjunctive therapeutic modalities for patients with various dermatologic disorders, including acne vulgaris, rosacea, retinoid-induced irritant dermatitis, atopic dermatitis, psoriasis, and the skin dryness that appears to occur with intrinsic and extrinsic aging. Therapeutic moisturizers, defined as those proven in clinical trials to be both compatible with topical therapies and biocompatible with the skin, not only improve the signs and symptoms of dry skin but also, as research has demonstrated, help maintain hydration and overall integrity of the stratum corneum. The type of humectants and emollients contained in a therapeutic moisturizer can affect the overall tolerability of the formulation. Dermatologists should recommend therapeutic moisturizers that are noncomedogenic, devoid of irritant ingredients, and compatible with many therapeutic regimens. But some factors have to be considered when assessing the safety of a moisturizer. We should consider harmful effects including allergenicity, irritation and carcinogenesis.

123
주제별 간행물
간행물명 수록권호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 5호 ~ 32권 5호

KCI등재 SCOUPUS

대한피부과학회지
58권 8호 ~ 58권 8호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 3호 ~ 46권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 7호 ~ 58권 7호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 4호 ~ 32권 4호

KCI등재 SCOUPUS

대한피부과학회지
58권 6호 ~ 58권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 2호 ~ 46권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 5호 ~ 58권 5호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 4호 ~ 58권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 1호 ~ 46권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 3호 ~ 58권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 2호 ~ 32권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 2호 ~ 58권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호

프로그램북(구 초록집)
71권 1호 ~ 71권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 9호 ~ 57권 9호
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