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대한피부과학회> 대한피부과학회지> 원저 : Collimated Low Fluence Q-switched Nd: YAG 레이저를 이용한 새로운 기미 치료법

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원저 : Collimated Low Fluence Q-switched Nd: YAG 레이저를 이용한 새로운 기미 치료법

Original Article : New Melasma Treatment by Collimated Low Fluence Q-switched Nd: YAG Laser

정세영 ( Se Yeong Jeong ) , 장성은 ( Sung Eun Chang ) , 박하나 ( Ha Na Bak ) , 최지호 ( Jee Ho Choi ) , 김일환 ( Il Hwan Kim )
  • : 대한피부과학회
  • : 대한피부과학회지 46권9호
  • : 연속간행물
  • : 2008년 09월
  • : 1163-1170(8pages)

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Background: Laser treatment in melasma has previously failed because of the resulting inflammation and consequent pigmentation and excessive thermal damage caused by the use of high fluence. Objective: This study is aimed at establishing the concept of the collimated low fluence Q-switched Nd: YAG laser as a treatment for melasma by investigating its therapeutic effects clinically as well as histopathologically. Methods: 27 patients were treated weekly with Q-switched Nd: YAG laser (1,064 nm wavelength, 7 mm spot size, 1.6~2.5 J/cm2 fluence) for 8 weeks. The results were evaluated based on standardized clinical images that used Robo skin analyzer, spectrophotometer, MASI score and general severity. Results: 17 (58.8%) patients showed "GOOD" (50~75% improvement) and no case of full recurrence was examined and partial recurrence was detected in 12/17 patients. Common adverse effects include pain, erythema, and temporary edema. Rarely partial hypopigmented macules and diffuse hyperpigmentation appeared. Additional studies, such as immunohistochemical examination and electron microscopic examination, are also currently in progress. Conclusion: The collimated low fluence Q-switched Nd: YAG Laser is effective in melasma treatment. This treatment method is a new concept that can be described as selective photothermolysis with minimal thermal damage and inflammation reaction to affected tissues by pigmentation. We consider this treatment method should be regarded as Minimized Selective Photothermolysis (MSP) that will provide a new effective treatment for melasma. (Korean J Dermatol 2008;46(9):1163~1170)

UCI(KEPA)

I410-ECN-0102-2009-510-008722099

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2020
  • : 9446


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1종설 : 경제협력개발기구(OECD) 회원국 및 기타 국가들에서 의료서비스와 연계된 피부미용사의 근무형태에 대한 연구

저자 : 정찬우 ( Chan Woo Jeong ) , 한승경 ( Seung Kyung Hann ) , 허창훈 ( Chang Hun Huh ) , 송해준 ( Hae Jun Song )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1149-1154 (6 pages)

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In 2008, Korea has enacted new ordinances about the role of estheticians, but this law can be interpreted ambiguously, restricting hiring of estheticians in medical clinics. The purpose of the study is to obtain information about medical-esthetic systems in other countries. We have taken a survey of this object from 30 OECD & Asian countries, and the questionnaires returned from a total of 22 countries (Australia, Austria, Canada, Denmark, Finland, France, Germany, Hungary, Japan, Netherlands, New Zealand, Norway, Portugal, Slovak Republic, Spain, Switzerland, Turkey, United Kingdom, United States, Singapore, Israel, and Thailand), were used for the final analysis. The results are summarized as follows. In most countries, estheticians working independently deal with only healthy, normal skin. In most countries, estheticians working independently have no right to operate any medical instruments. In all 17 countries that returned the questionnaires medical clinics can employ estheticians, and only theses estheticians who belong to the medical clinics can handle the non-invasive medical instruments under the supervision of doctors. In 17 countries that have related legal regulations, nurses, under the control of doctors, can perform wider range of duties in various settings than estheticians. The survey concludes that the duties of estheticians are closely related with medical skin care services and estheticians can perform various non-invasive medical procedures only under the control of doctors. From consulting a variety of medical-esthetic systems in other countries, we propose that the estheticians be allowed to work in medical clinics to provide better medical services for the patients and to make more chances of employment for themselves. (Korean J Dermatol 2008;46(9):1149~1154)

2원저 : 만성 특발성 두드러기에서 제한식이의 효과

저자 : 박창근 ( Chang Keun Park ) , 최지훈 ( Ji Hoon Choi ) , 박천욱 ( Chun Wook Park ) , 이철헌 ( Cheol Heon Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1155-1162 (8 pages)

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Background: Although the pathogenesis of chronic idiopathic urticaria (CIU) has not yet been fully elucidated, several previous studies have identified food additives or high amounts of histamine containing foods as possible eliciting factors of chronic idiopathic urticaria (CIU). Objective: The aim of this study was to evaluate the effect of restricting pseudoallergens and histamines from the diets of patients affected with CIU. Methods: Fourteen CIU patients with Acetylsalicylic acid (ASA) intolerance were prescribed a pseudoallergen restricted diet, whilst, fifteen CIU patients with ASA tolerance were prescribed a histamine restricted diet for 4 weeks. A control group of thirty nine CIU patients were not given a restricted diet. After 4 weeks, we estimated the improvement of symptoms and the change in the number of antihistamine tablets taken in each of the three groups. Results: Neither of the restricted diets induced a significant improvement of symptoms compared with the control group (p>0.05). Furthermore, there was no significant decrease in the number of antihistamine tablets taken in the restricted diet groups compared with the control group as well (p>0.05) Conclusion: According to our results, we suggest that pseudoallergen or histamine restricted diets are not necessary in CIU patients. (Korean J Dermatol 2008;46(9):1155~1162)

3원저 : Collimated Low Fluence Q-switched Nd: YAG 레이저를 이용한 새로운 기미 치료법

저자 : 정세영 ( Se Yeong Jeong ) , 장성은 ( Sung Eun Chang ) , 박하나 ( Ha Na Bak ) , 최지호 ( Jee Ho Choi ) , 김일환 ( Il Hwan Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1163-1170 (8 pages)

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Background: Laser treatment in melasma has previously failed because of the resulting inflammation and consequent pigmentation and excessive thermal damage caused by the use of high fluence. Objective: This study is aimed at establishing the concept of the collimated low fluence Q-switched Nd: YAG laser as a treatment for melasma by investigating its therapeutic effects clinically as well as histopathologically. Methods: 27 patients were treated weekly with Q-switched Nd: YAG laser (1,064 nm wavelength, 7 mm spot size, 1.6~2.5 J/cm2 fluence) for 8 weeks. The results were evaluated based on standardized clinical images that used Robo skin analyzer, spectrophotometer, MASI score and general severity. Results: 17 (58.8%) patients showed "GOOD" (50~75% improvement) and no case of full recurrence was examined and partial recurrence was detected in 12/17 patients. Common adverse effects include pain, erythema, and temporary edema. Rarely partial hypopigmented macules and diffuse hyperpigmentation appeared. Additional studies, such as immunohistochemical examination and electron microscopic examination, are also currently in progress. Conclusion: The collimated low fluence Q-switched Nd: YAG Laser is effective in melasma treatment. This treatment method is a new concept that can be described as selective photothermolysis with minimal thermal damage and inflammation reaction to affected tissues by pigmentation. We consider this treatment method should be regarded as Minimized Selective Photothermolysis (MSP) that will provide a new effective treatment for melasma. (Korean J Dermatol 2008;46(9):1163~1170)

4원저 : 지도모양혀 55예의 임상적 고찰

저자 : 최윤진 ( Yoon Jin Choi ) , 방동식 ( Dong Sik Bang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1171-1178 (8 pages)

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Background: Geographic tongue (GT) is an inflammatory disorder of the oral mucosa. The clinical characteristics of GT have not been studied in Korea. Objective: The purpose of this study was to investigate the clinical characteristics, associated factors, and treatment outcomes of GT. Methods: We reviewed the medical records and clinical photographs of 55 cases who had been diagnosed with GT during the last 5 years. Results: Of the 55 cases, 15 were male and 40 were female. The average age of onset was 29.3 years, and the highest incidence occurred in the 10~19 age group. The clinical type without circinate border was found in 67.3% of the cases and the clinical type with circinate border in 32.7% of the cases. Fissured tongue was found in 40% of the cases. Except for the 11 asymptomatic cases, the rest of the cases complained of various symptoms related to pain, irritation, and sensory changes. Hot, spicy or salty food acted as an aggravating factor in 74.5% of the cases and fatigue or stress in 61.8% of the cases. The majority of our cases (80.0%) were treated with topical steroid or steroid gargle or with a combination of both, and improvement was observed in 75.0% of this group. Conclusion: This is the first clinical study of GT in Korean literature. This study showed differences with previous studies in the proportion of cases with symptoms and aggravating factors. This study also suggested that topical steroid or steroid gargle could be the treatment of choice for GT. (Korean J Dermatol 2008;46(9):1171~1178)

5원저 : 최근 6년간 피부과에 의뢰된 매독환자의 임상적 고찰(2002~2007) -임상 양상 및 증상기 변화-

저자 : 신봉석 ( Bong Seok Shin ) , 송지영 ( Ji Young Song ) , 정병수 ( Byoung Soo Chung ) , 최규철 ( Kyu Churl Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1179-1185 (7 pages)

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Background: There are many differences in the prevalence of syphilis according to the objects and districts. Recently, the incidence of syphilis increased in the world because of various factors. Objective: The purpose of this study is to investigate the changes of the epidemiological, clinical characteristics, and stages of syphilis. Methods: We selected 357 patients with reactive results on VDRL among 79,991 cases who visited in our hospital, between January 2002 and December 2007. We assessed the age, gender, skin lesion, serologic result, clinical stage, treatment history, and underlying disease. Results: During the 7-year period under study, the reactive rate of serum VDRL test was 4.5% in 79,991 people (preoperation or admission examinees: 35.0%. physical examinees: 30.8%, skin lesion: 21.3%, partner`s (+): 9.0%, pregnant women: 3.7%). The annual incidence of syphilis had increased from 3.5% in 2002 to 6.3% in 2007. On a total 357 sera with reactive results on VDRL, the symptomatic syphilis rate was 21.3%, increased from 13.6% in 2002 to 26.8% in 2007 (p=0.001). Statistically, there are differences in age distribution between both sexes. The male:female ratio was 1:3.3 in 0~19 years and 1.9:1 in 60~69 years (p=0.029). The incidence of symptomatic syphilis cases was 8 (66.7%) in 0~19 years, 22 (39.3%) in 20~29 years, while latent syphilis was 53 (74.6%) in 50~59 years and 35 (60.3%) in 60~69 years (p<0.001). Conclusion: This study suggests that the incidence of symptomatic syphilis may be increasing. Further observation, analysis, and continued vigilance in the general population are required. (Korean J Dermatol 2008;46(9):1179~1185)

6원저 : 인공피부모델에서 지방조직 유래 중간엽 줄기세포가 표피와 기저막 형성에 미치는 효과

저자 : 변희진 ( Hee Jin Byun ) , 이승호 ( Seung Ho Lee ) , 김지은 ( Ji Eun Kim ) , 김연경 ( Yon Kyung Kim ) , 조광현 ( Kwang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1186-1193 (8 pages)

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Background: There is an increasing need for making a more ideal artificial skin model. Objective: To evaluate the effects of adipose tissue-derived mesenchymal stem cells (ATMSC) on the formation of epidermis and basement membrane in artificial skin models. Methods: ATMSC were isolated from lipo-aspirated fat tissues, and their phenotypes were confirmed by cell surface markers. Three kinds of artificial skin models were made using three different dermal substitutes. The dermal substitutes in the three models contained fibroblasts only, fibroblasts together with ATMSC or ATMSC only. The formation of epidermis and basement membrane was evaluated by immunohistochemical stains and transmission electron microscopy. Results: Among the three models, the model with both fibroblasts and ATMSC in the dermal substitute showed the most excellent formation of epidermis and, especially, basement membrane. In this model, the basement membrane proteins, laminin and type IV collagen, were expressed most apparently at the dermo-epidermal junction and, lamina lucida, lamina densa and anchoring fibrils were most evidently observed under transmission electron microscopy. Whereas, the model with only ATMSC did not show keratin 1 expression, suggesting that the ``skin-type`` stratified squamous epithelium was not formed well. Conclusion: ATMSC together with fibroblasts can be used effectively in constructing artificial skin models. (Korean J Dermatol 2008;46(9):1186~1193)

7원저 : 정맥,림프관기형에서의 혈관경화요법의 효과와 안전성: 장기간 추적관찰

저자 : 이재철 ( Jae Chul Lee ) , 김호연 ( Ho Youn Kim ) , 최윤석 ( Yoon Seok Choe ) , 이석종 ( Seok Jong Lee ) , 김도원 ( Do Won Kim ) , 정호윤 ( Ho Yun Chung ) , 백승국 ( Seung Kug Baik ) , 이종민 ( Jong Min Lee ) , 허승 ( Seung Huh )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1194-1200 (7 pages)

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Background: Surgical excision and alcohol sclerotherapy have been used to treat congenital vascular malformations (CVM) with a significant success rate but the methods have also left marked morbidity. The alternative, sclerotherapy using ordinary sclerosants, although resulting in trivial complications, has a relatively low cure rate and is rarely used in Korea for CVM management. Objective: To evaluate the effects and side effects of sclerotherapy using ordinary sclerosants such as polidocanol (POL) and sodium tetradecyl sulfate (STS) for the treatment of CVM of a venous and lymphatic type. Methods: To confirm the long-term effects and safety with at least a 3-year follow-up, we chose a total of 26 patients who had undergone sclerotherapy between 2000 to 2004. There were 22 venous malformations (VMs) and 4 lymphatic malformations (LMs) which were rather small and superficial, not beyond muscular fascia. Sclerotherapy using POL and STS was performed by blind intraluminal and/or intralesional injection without the aid of imaging methods such as ultrasound examination. The results were evaluated by the patients` subjective satisfaction, physical examination, comparison of photographs and/or radiological examinations, then they were classified into 4 groups; excellent (improvement >75%), good (50~75%), fair (25~49%) and poor (<25%). Results: Twenty two VMs comprised 14 in the excellent group (66.7%), 6 in the good group (25.0%), 1 in the fair group (4.2%) and 1 in the poor group (4.2%). Two LMs of macrocystic type revealed excellent results but the other two showing microcystic type revealed poor results. The dose of sclerosant was 0.1 to 2 ml in every session and a total of 1 to 6 sessions (average: 2.2) were performed. Only one VM showed hyperpigmentation as a side effect. Conclusion: Sclerosants for ordinary varicose vein eradication can be used on the treatment of small and superficial venous malformations and macrocystic-lymphatic malformations with relative efficacy and safety. (Korean J Dermatol 2008;46(9):1194~1200)

8원저 : 전신성 광택태선에 대한 임상적 연구

저자 : 김성우 ( Sung Woo Kim ) , 이운하 ( Un Ha Lee ) , 박현수 ( Hyun Su Park ) , 장상재 ( Sang Jai Jang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1201-1207 (7 pages)

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Background: Generalized lichen nitidus is a rare subtype of lichen nitidus characterized by multiple, flesh-colored, shiny papules occurring over the entire body. Objective: We investigated the clinical features of generalized lichen nitidus in patients followed up at our institution. Methods: The patients with generalized lichen nitidus diagnosed clinically and histopathologically between 1998 and 2007 were reviewed. Results: Twelve patients (9 males and 3 females) were enrolled in this study and the mean age at onset was 10.3 (range: 4~27) years. Of the 12 patients, 5 (41.7%) experienced pruritus and 4 (33.3%) had atopic dermatitis. None of the patients had a family history of lichen nitidus. Nine patients were treated with topical steroids, systemic steroids, oral antihistamines, or narrow-band UVB. We propose that narrow band UVB is an effective treatment modality for generalized lichen nitidus. The mean duration to clearance was 37.7 (range: 7~120) months and the disease was relapsing in 2 patients. The duration to clearance was correlated to the age at onset (p=0.0005) and to the duration at the first visit (p=0.0000), whereas it was not related to the sex of the patient, pruritus or the accompanying atopic dermatitis. Conclusion: Generalized lichen nitidus is often associated with varying degrees of pruritus and the clinical course of the disease tends to be chronic. We propose that onset at an early age and the short duration of disease at the first visit are good prognostic factors, and that narrow band UVB is an effective treatment modality for generalized lichen nitidus. (Korean J Dermatol 2008;46(9):1201~1207)

9원저 : Indocyanine Green과 805 nm Diode Laser를 이용한 여드름 치료에 대한 유효성 평가

저자 : 이두락 ( Doo Rak Lee ) , 박미연 ( Mi Youn Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1208-1215 (8 pages)

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Background: Acne vulgaris is one of the most common dermatologic diseases and the main method of treatment is antibiotics and retinoids. However, many patients experience a need for a different treatment because of the transient effect and severe adverse effects. The study reported herein evaluated the effect and safety on acne vulgaris of 805 nm diode laser and topical Indocyanine green (ICG). Objective: To demonstrate the efficacy of the near-infrared diode laser phototherapy in combination with topical application of ICG in the treatment of acne vulgaris. Methods: Twenty-three volunteers with varying degrees of acne were enrolled in the study. Half of the face was stained by ICG. After 15 minutes, the whole face was irradiated by 805 nm diode laser. The procedure was carried out two times a week for 4 weeks. Inflammatory, non-inflammatory acne lesions were counted and sebum levels of both cheeks were measured. Results: The mean reduction of the inflammatory lesion counts was 43% in the ICG-diode laser group. The mean clearance of non-inflammatory lesions was 25% in the ICG-diode laser group. Significant reduction of acne lesions were observed in ICG-diode laser group compared to diode laser group (p<0.05). The adverse effects were negligible on both sides of the face. Conclusion: ICG and diode laser therapy is effective in the treatment of moderate to severe acne vulgaris, and none of significant adverse effects were observed. (Korean J Dermatol 2008;46(9):1208~1215)

10증례 : 동측 하지 단축을 동반한 패리-롬버그 증후군 1예

저자 : 원태혁 ( Tai Hyok Won ) , 박석돈 ( Seok Don Park ) , 서필승 ( Phil Seung Seo )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 9호 발행 연도 : 2008 페이지 : pp. 1216-1220 (5 pages)

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Parry-Romberg syndrome is an extremely rare connective tissue disorder. It might be a form of linear scleroderma, and it manifests as progressive hemifacial atrophy, epilepsy, exophthalmos or alopecia. Herein we report a case of Parry-Romberg syndrome. A 68-year-old woman had left hemifacial atrophy, shortening and deformity of the left leg, and deformities to her side fingers that occurred from her 1st decade to 2nd decade. Sclerotic change had stopped spontaneously when she was 20 years old. Histopathologically, there were a few signs of skin appendages, but no sclerotic change. On autoimmune antibody test, no positivity was shown. X-ray showed shrinkage of the lung field, elevation of the left diaphragm, shortening of length and reduction of bone mass in the left femur, tibia, and fibula. And there were multiple melorheostasis. Neck CT showed left facial sclerotic change, bone mass loss, and multiple melorheostasis. Because the progression of sclerosis had stopped the patient did not receive any treatment. (Korean J Dermatol 2008;46(9):1216~1220)

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대한피부과학회지
58권 9호 ~ 58권 9호

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Annals of Dermatology
32권 6호 ~ 32권 6호

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Annals of Dermatology
32권 5호 ~ 32권 5호

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대한피부과학회지
58권 8호 ~ 58권 8호

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대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 3호 ~ 46권 3호

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대한피부과학회지
58권 7호 ~ 58권 7호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 4호 ~ 32권 4호

KCI등재 SCOUPUS

대한피부과학회지
58권 6호 ~ 58권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 2호 ~ 46권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 5호 ~ 58권 5호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 4호 ~ 58권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 1호 ~ 46권 1호

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대한피부과학회지
58권 3호 ~ 58권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 2호 ~ 32권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 2호 ~ 58권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

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