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대한피부과학회> 대한피부과학회지> 원저 : 구강편평태선 35예의 임상적 고찰

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원저 : 구강편평태선 35예의 임상적 고찰

A Clinical Study of Oral Lichen Planus

김대석 ( Dae Suk Kim ) , 방동식 ( Dong Sik Bang )
  • : 대한피부과학회
  • : 대한피부과학회지 45권1호
  • : 연속간행물
  • : 2007년 01월
  • : 1-8(8pages)
피인용수 : 40건

(자료제공: 네이버학술정보)

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Background: Oral lichen planus (OLP) is a relatively common chronic inflammatory oral mucosal disease of unknown cause. Oral lesions in OLP are chronic, rarely undergo spontaneous remission, are potentially premalignant and are often a source of morbidity. Objective: The purpose of our investigation was to describe the clinical characteristics of 35 patients with biopsy-proven OLP. Methods: We reviewed the medical records and clinical photographs of 35 patients who had been diagnosed with OLP during the last 5 years, from January 2001 to March 2006. We identified average age of onset, gender distribution, presence of family history, clinical types, location of the oral lesion, symptoms, associated dermatologic and systemic disease and treatment modalities. Results: Of the 35 patients, 65.7% were women and 34.3% men. The average age of onset for men was 41.2 years and for women was 52.4 years (overall average age of onset was 48.5 years). Only 5 patients had a family history of OLP, which had not been proven by histologic examination. Of the 35 OLP patients, the reticular type was found in 45.7%, the erythematous type in 31.4% and erosive type in 22.9% of patients. The most common site of oral lesions was the buccal mucosa, which was found in 57.1 % of the patients. The lips were the second most commonly involved site at 48.6%, then the tongue at 8.6% and gingiva at 5.7%. Except for the 4 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, a burning sensation, pruritus and irritation. Many cutaneous and systemic diseases were associated with OLP patients. 3 patients had concomitant cutaneous lichen planus. Only 1 patient was found to be infected with hepatitis C virus. Various treatments had been tried by all patients. Oral squamous cell carcinoma developed in 1 patient at sites previously diagnosed by biopsy as OLP. Conclusion: This is the first clinical study of OLP patients in the Korean dermatologic literature. The clinical features of patients in this survey share many similarities with those reported previously, but showed some differences too. The clinical findings of OLP should be evaluated in much larger groups of patients and more experimental investigations should be conducted to find out exact pathogenesis and effective treatments for OLP. (Korean J Dermatol 2007;45(1):1~8)

UCI(KEPA)

I410-ECN-0102-2009-510-000034165

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • :
  • : 학술지
  • : 연속간행물
  • : 1960-2019
  • : 9233


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1원저 : 구강편평태선 35예의 임상적 고찰

저자 : 김대석 ( Dae Suk Kim ) , 방동식 ( Dong Sik Bang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 1-8 (8 pages)

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Background: Oral lichen planus (OLP) is a relatively common chronic inflammatory oral mucosal disease of unknown cause. Oral lesions in OLP are chronic, rarely undergo spontaneous remission, are potentially premalignant and are often a source of morbidity. Objective: The purpose of our investigation was to describe the clinical characteristics of 35 patients with biopsy-proven OLP. Methods: We reviewed the medical records and clinical photographs of 35 patients who had been diagnosed with OLP during the last 5 years, from January 2001 to March 2006. We identified average age of onset, gender distribution, presence of family history, clinical types, location of the oral lesion, symptoms, associated dermatologic and systemic disease and treatment modalities. Results: Of the 35 patients, 65.7% were women and 34.3% men. The average age of onset for men was 41.2 years and for women was 52.4 years (overall average age of onset was 48.5 years). Only 5 patients had a family history of OLP, which had not been proven by histologic examination. Of the 35 OLP patients, the reticular type was found in 45.7%, the erythematous type in 31.4% and erosive type in 22.9% of patients. The most common site of oral lesions was the buccal mucosa, which was found in 57.1 % of the patients. The lips were the second most commonly involved site at 48.6%, then the tongue at 8.6% and gingiva at 5.7%. Except for the 4 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, a burning sensation, pruritus and irritation. Many cutaneous and systemic diseases were associated with OLP patients. 3 patients had concomitant cutaneous lichen planus. Only 1 patient was found to be infected with hepatitis C virus. Various treatments had been tried by all patients. Oral squamous cell carcinoma developed in 1 patient at sites previously diagnosed by biopsy as OLP. Conclusion: This is the first clinical study of OLP patients in the Korean dermatologic literature. The clinical features of patients in this survey share many similarities with those reported previously, but showed some differences too. The clinical findings of OLP should be evaluated in much larger groups of patients and more experimental investigations should be conducted to find out exact pathogenesis and effective treatments for OLP. (Korean J Dermatol 2007;45(1):1~8)

2원저 : 습진성 입술염 환자에서 첩포검사 결과에 관한 임상적 연구

저자 : 이종록 ( Jong Rok Lee ) , 이혜영 ( Hye Young Lee ) , 백진옥 ( Jin Ok Baek ) , 노주영 ( Ju Young Roh ) , 최광성 ( Gwang Seong Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 9-13 (5 pages)

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Background: Cheilitis is a common problem, the cause of which is often obscure. Objective: We evaluated the frequency of allergic contact cheilitis and irritant contact cheilitis among 23 eczematous cheilitis patients via patch testing and assessment of past medical history. Methods: This study consisted of 23 patients with eczematous cheilitis who had visited the Department of Dermatology, two University Hospital in Incheon, between January 2005 and August 2006. Of the 23 patients, 20 were female, and the age range was 15 to 70 years. We analyzed the clinical characteristics (age, gender, duration, atopic or allergic disease, lip licking) of the patients. All patients were patch-tested with the Korean standard series, 9 patients with the Cosmetic series and 5 patients with as is test. We then analyzed the results of the patch tests and evaluated the relevance of any positive results. Results: Of the cases, 34.78% were identified as irritant contact dermatitis (ICD), and 30.43% as allergic contact dermatitis (ACD). Furthermore, of the 23 patients, 11 were positive to one or more antigen and 7 of these had a clinical relevance for positive antigen. The substances causing a positive reaction, triggering ACD were identified as medicaments applied to the lip, lipstick ingredients and toothpaste. Conclusion: The most common cause of cheilitis was irritation, frequently caused by lip licking. But, almost one third was caused by ACD. Patients with chronic eczematous cheilitis should be patch-tested to identify the materials causing ACD. (Korean J Dermatol 2007;45(1):9~13)

3원저 : 여드름 치료에 있어 ALA와 여드름 모드 IPL을 병합한 광화학 요법과 여드름 모드 IPL만을 이용한 광치료의 비교 연구

저자 : 전혜주 ( Hyae Joo Jeon ) , 김성현 ( Seong Hyun Kim ) , 함정희 ( Jeong Hee Hahm ) , 황규광 ( Kyu Kwang Whang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 14-22 (9 pages)

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Background: Acne vulgaris is one of the most prevalent and emotionally debilitating dermatologic diseases. Emerging problems with conventional acne treatments, such as the resistance of Propionibacterium acnes to antibiotics and the safety of oral isotretinoin, create a demand for other treatment modalities for acne. An evolving understanding of the Propionibacterium acnes-produced porphyrins and the development of a number of light sources have led to the application of photodynamic therapy for the treatment of acne. Objective: To study the effect of light therapy on the treatment of Acne Vulgaris using acne mode intense pulsed light (IPL), and photodynamic therapy with a combination of topical 5-Aminolevulinic acid (ALA, 20%) and acne mode IPL. A comparison of the two treatment modalities would then be made to examine the effect on inflammatory acne lesions and sebum excretion. Methods: Thirteen patients with varying degrees of acne were included in the study after a 4 week washout period. ALA (20%) was applied to half of the face on each patient. After one hour, the whole face was exposed to intense pulsed light (DECA(R)), Italia) using an acne mode (400~1,200 nm) starting at a fluence of 11 J/cm2. The procedure was carried out three times with 2 week intervals, and the patients were evaluated on post-op 2nd, 4th, and 6th weeks. Histologic changes were observed before and after treatment. Results: After the first and second treatment, there was a statistically significant reduction in inflammatory acne lesion counts and the amount of sebum production from baseline, in both the ALA-PDT group and the IPL group (p<0.05). However, no statistically significant reduction was shown after the third treatment in both groups. There was a slightly higher reduction in the count of inflammatory lesions and the amount of sebum production in the ALA-PDT site compared to the IPL site, but in was not statistically significant. On histologic examination, dermal inflammatory cell infiltrations around the perivascular and periappendageal area were significantly reduced and sebaceous glands became smaller after the 3rd treatment. The adverse effects were negligible. Conclusion: ALA-PDT using acne mode IPL, and light therapy using acne mode IPL alone were effective in the reduction of inflamed lesions and sebum secretion in patients with mild to moderate acne vulgaris. Furthermore, no significant adverse effects were observed with both treatments. However, no remarkable contrast of therapeutic effect was statistically observed between the two therapies either. (Korean J Dermatol 2007;45(1):14~22)

4원저 : 장시간 수화가 표피투과장벽에 미치는 영향

저자 : 안성구 ( Sung Ku Ahn ) , 이은희 ( Eun Hee Lee ) , 홍승필 ( Seung Phil Hong ) , 최응호 ( Eung Ho Choi ) , 이승헌 ( Seung Hun Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 23-33 (11 pages)

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Background: Water exposure is considered an important causative factor of irritant contact dermatitis. It is also known that water exposure can disrupt the stratum corneum (SC). However, there are only a few morphologic studies on the effect of water contact on the skin. Objective: The aim of our study was to investigate the effects of prolonged water exposure on the permeability barrier and the ultrastructure of the SC intercellular lipids. Methods: After prolonged water exposure of hairless mouse skin in vivo for 24, 36, 48, and 72 hrs respectively, the permeability barrier function was assessed by transepidermal water loss (TEWL) measurement, and the ultrastructure of SC by electron microscopy using osmium tetraoxide and ruthenium tetraoxide postfixation and calcium ion capture cytochemistry. Additionally, the lipid composition was evaluated using confocal microscopy with nile red stain and the integrity of the SC assessed using a lanthanum tracer. Results: After prolonged water exposure, water caused a significant increase in TEWL with disappearance of the calcium gradient, but this did not significantly influence the recovery rate of TEWL. The intercellular lipids were disrupted, and multiple lacunae containing abnormal delaminated materials within the intercellular spaces were observed. Lanthanum tracer penetrated into the intercellular space of the SC. There was a progressive decrease in nile red staining with neutral lipid content. With increasing exposure to water, these results were more evident. Conclusion: Our results provide a better understanding of the disruptive effect of prolonged water exposure on barrier lipids, the penetration-enhancing effect of water and the increased susceptibility to irritants, with regard to duration of water exposure. (Korean J Dermatol 2007;45(1):23~33)

5증례 : 모낭성 점액증이 동반된 호산구성 농포성 모낭염 1예

저자 : 김윤영 ( Yoon Young Kim ) , 김시용 ( Si Yong Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 34-36 (3 pages)

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Eosinophilic pustular folliculitis (Ofuji`s disease) is characterized by inflammatory infiltration of the pilosebaceous units by numerous eosinophils. Clinically, recurrent crops of papules and plaques studded with sterile follicular pustules can be seen. Follicular mucinosis is a reaction pattern which occurs in the follicular epithelium and is characterized by a mucinous degeneration of the outer sheath of follicles and sebaceous glands. The condition can occur in various diseases. Herein, we report a case of a 46-year old woman who presented with a recurrent episode of papules and follicular pustules, revealing inflammatory infiltration in and around the pilosebaceous units and prominent eosinophils, in addition to follicular mucinosis. (Korean J Dermatol 2007;45(1):34~36)

6증례 : Cyclosporine 투여로 호전을 보인 Ofuji 구진성 홍피증 1예

저자 : 장효찬 ( Hyo Chan Jang ) , 김희정 ( Hee Jeung Kim ) , 현동녘 ( Dong Nyeok Hyun ) , 이성우 ( Sung Woo Lee ) , 정현 ( Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 37-39 (3 pages)

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Papuloerythroderma of Ofuji is an uncommon dermatological disorder of unknown etiology and is characterized by a pruritic eruption of widespread confluent papules in vast sheets over the skin, but spares the skin folds (the so-called `deck-chair` effect). We present a case of a patient with papuloerythroderma of Ofuji of unknown cause. Treatment with oral and topical corticosteroids, antihistamines, and narrow-band UVB phototherapy proved to be ineffective in helping the condition but considerable clinical improvement was obtained with cyclosporine. (Korean J Dermatol 2007;45(1):37~39)

7증례 : 윗입술에 발생한 선천성 보통 청색 모반 1예

저자 : 이중선 ( Joong Sun Lee ) , 도정은 ( Jeong Eun Do ) , 김유찬 ( You Chan Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 40-42 (3 pages)

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The blue nevus consists of papules or a plaque-like aggregate of aberrant dermal melanocytes actively producing melanin in the reticular dermis. The common blue nevus clinically presents as a 2~10 mm sized, well-demarcated, papular, bluish-black lesion, typically on the dorsal surface of the hands or feet. However, it has rarely been reported on the mucosal lesions such as the oral cavity. It is usually seen as an aquired form. We report a case of a large, congenital, common blue nevus on the upper lip. (Korean J Dermatol 2007;45(1):40~42)

8증례 : 두피로의 전이가 초기 증상으로 나타난 갑상선암 1예

저자 : 김혜경 ( Hye Kyoung Kim ) , 김학주 ( Hak Ju Kim ) , 고유수 ( Yoo Soo Ko ) , 최희봉 ( Hee Bong Choi ) , 조옥자 ( Ok Ja Joh ) , 이재승 ( Jai Seung Lee ) , 송계용 ( Kye Young Song )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 43-46 (4 pages)

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Cutaneous metastasis from the papillary thyroid carcinoma is rare. An otherwise asymptomatic 57-year-old man presented with a 3 year history of a steadily-enlarging scalp nodule. The histopathologic features showed a complicated pattern of follicular architecture formed by papilliform fibrovascular stroma. The tumor cells stained positive for thyroglobulin. A subsequent thyroid sonogram revealed multiple nodules in both lobes and resection of the thyroid gland identified papillary thyroid carcinoma. The solitary scalp nodule was presenting sign of an occult thyroid carcinoma. We report a case of cutaneous metastasis from the papillary thyroid carcinoma. (Korean J Dermatol 2007;45(1):43~46)

9증례 : 재발성 호산구성 피부 혈관염 1예

저자 : 김정욱 ( Jung Wook Kim ) , 오두진 ( Doo Jin Oh ) , 박정훈 ( Jeong Hoon Park ) , 이드보라 ( De Bo Rah Lee ) , 황선욱 ( Seon Wook Hwang ) , 박성욱 ( Sung Wook Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 47-50 (4 pages)

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Recurrent cutaneous eosinophilic vasculitis (RCEV) is a rare cutaneous disease characterized by necrotizing vasculitis of small vessels, with exclusive eosinophilic infiltration and minimal, or no leukocytoclasis. It presents with recurrent erythematous or purpuric papules or plaques, or angioedema associated with peripheral eosinophilia. This disease follows a benign chronic course without evidence of systemic involvement. Systemic corticosteroid therapy is effective but the disease commonly pursues a relapsing and remitting course. Herein, we report a case of RCEV that was effectively treated with systemic corticosteroids and dapson(R) (diaminodiphenylsulphone). Furthermore, the patient did not show a relapse of the disease in spite the tapering the systemic corticosteroid dose. (Korean J Dermatol 2007;45(1):47~50)

10증례 : 가족성 다발성 지방종증 2예

저자 : 좌승욱 ( Seung Wook Jwa ) , 장봉석 ( Bong Seok Jang ) , 김병수 ( Byung Soo Kim ) , 김성준 ( Sung Jun Kim ) , 김문범 ( Moon Bum Kim ) , 오창근 ( Chang Keun Oh ) , 권경술 ( Kyung Sool Kwon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 1호 발행 연도 : 2007 페이지 : pp. 51-54 (4 pages)

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Familial multiple lipomatosis is a rare hereditary disorder with a proposed autosomal dominant inheritance. Clinically, multiple well-circumscribed, encapsulated lipomas occur on the extremities and trunk. Familial multiple lipomatosis is often confused with multiple symmetric lipomatosis, which is a condition involving a diffuse fatty infiltration around the neck and shoulders. We report two cases of familial multiple lipomatosis with typical clinical features and familial history. To the best of our knowledge, these are the first cases of familial multiple lipomatosis in Korea. (Korean J Dermatol 2007;45(1):51~54)

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KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 3호 ~ 45권 3호

KCI등재 SCOUPUS

대한피부과학회지
57권 8호 ~ 57권 8호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 5호 ~ 31권 5호

한국피부장벽학회지
21권 1호 ~ 21권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 7호 ~ 57권 7호

KCI등재 SCOUPUS

대한피부과학회지
57권 6호 ~ 57권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 2호 ~ 45권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 44호 ~ 31권 44호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 4호 ~ 31권 s4호

KCI등재 SCOUPUS

대한피부과학회지
57권 5호 ~ 57권 5호

KCI등재 SCOUPUS

대한피부과학회지
57권 4호 ~ 57권 4호

프로그램북(구 초록집)
71권 1호 ~ 71권 1호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
11권 0호 ~ 26권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 3호 ~ 31권 3호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
27권 1호 ~ 33권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
10권 0호 ~ 8권 0호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
33권 3호 ~ 37권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
37권 3호 ~ 39권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
40권 1호 ~ 42권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
1권 0호 ~ 45권 1호
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