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대한피부과학회> 대한피부과학회지> 원저 : 성인 아토피피부염 환자에서 삶의 질 평가의 임상적 유용성

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원저 : 성인 아토피피부염 환자에서 삶의 질 평가의 임상적 유용성

Life Quality Assessment among Adult Patients with Atopic Dermatitis

이희정 ( Hee Jung Lee ) , 박창욱 ( Chang Ook Park ) , 이주희 ( Ju Hee Lee ) , 이광훈 ( Kwang Hoon Lee )
  • : 대한피부과학회
  • : 대한피부과학회지 45권2호
  • : 연속간행물
  • : 2007년 02월
  • : 159-164(6pages)
피인용수 : 14건

(자료제공: 네이버학술정보)

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Background: Quantification of quality of life (QOL) related to disease severity is important in patients with atopic dermatitis (AD), because the assessment provides additional information to the traditional objective clinical scoring systems. Objective: We evaluated the association between QOL and severity scoring systems of AD. Methods: We assessed QOL, clinical severity scores, and total IgE in peripheral blood in 41 AD patients at our dermatology clinic over an 8 month period. QOL was assessed at two visits with a monthly interval by a dermatology-specific questionnaire (Dermatology Life Quality Index (DLQI)). Eczema Area and Severity Index (EASI) and Scoring of Atopic Dermatitis (SCORAD) was used to measure disease severity. Visual analogue scale (VAS) of pruritus and loss of sleep (LOS) were also recorded. Results: The mean DLQI was 11.6. For DLQI the dimension with the highest score was 26, and the lowest score was 2. DLQI did not correlate with EASI at visit 1, but correlated well with EASI at visit 2. Changes of DLQI in each patient between visits 1 and 2 were significant (p<0.05) and positively correlated with the severity scoring (EASI, SCORAD). In addition, the sum of VAS of pruritus and loss of sleep a correlated well with the DLQI and EASI at each visit. Conclusion: AD has a great impact on QOL of patients. Although the DLQI is known as an excellent method of measuring QOL in patients with dermatologic disease, correlation between DLQI and disease severity was not definite. However, changes of DLQI during follow-up significantly correlated with clinical course in each patient. Therefore, DLQI can be an important parameter when evaluating the disease course in AD patients. (Korean J Dermatol 2007;45(2):159~164)

UCI(KEPA)

I410-ECN-0102-2009-510-000037535

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2020
  • : 9355


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1원저 : 원형탈모증 환자에서 병리조직학적 등급과 임상적 예후 인자 및 치료 효과와의 상호 관련성

저자 : 권오언 ( Oh Eon Kwon ) , 구본석 ( Bon Seok Ku ) , 이영규 ( Yeong Kyu Lee ) , 이채욱 ( Chae Wook Lee ) , 김기호 ( Ki Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 111-118 (8 pages)

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Background & Objective: Prognosis of alopecia areata have been attributed to various factors; age of onset, duration before treatment, extent of hair loss, clinical type of alopecia areata, sex, nail changes or accompaniment of atopy. The study on prognostic factors has only been conducted from statistical data of patients and individualized medical conditions. The histopathologic findings of alopecia areata have been investigated by the minute pathologic changes associated with the hair growth cycle in the transverse section. Moreover, these findings were used mainly for diagnostic purpose, but clinical significance of histopathologic severity in prognosis has not been established to date. Methods: A clinical study, including histopathological and clinical evaluation was conducted on 108 alopecia areata patients between July 1997 and August 2005 at the Department of Dermatology, Dong-A University Hospital. The evaluation criteria included; sex, age, age at onset, duration before treatment, clinical types, extent of hair loss, nail changes, accompaniment of atopy, and scalp biopsy finding. The clinical types of alopecia areata were classified as follows; patchy, subtotalis, totalis, and universalis. The extent of hair loss before treatment was classified into 5 grades (S1~S5), according to the method designed by Olsen and Canfield. Clinical improvements after treatment were classified into 5 grades according to degree of regrowth and reduction of the alopecia areata area. Biopsy findings were classified into 4 grades (type I, II, III, and IV) according to classification by Uno and Orecchia. Results: The mean age was 28.6 years, without any sex predominance. The severe histopathologic gradings were significantly associated with early age of onset (p=0.008), a long disease duration before treatment (p=0.003), a greater extent of hair loss (p=0.009), and poor response to treatment (p=0.036). The histopathologic gradings were not significantly associated with sex (p=0.657), clinical types of alopecia areata (p=0.529), nail changes (p=0.746), or accompaniment of atopy (p=0.924). Conclusion: Histopathologic gradings in alopecia areata, using vertical sections are significantly associated with prognostic factors such as age of onset, extent of hair loss, disease duration before treatment, as well as the response to treatment. Therefore we consider that the histopathologic grading system is recommendable as an independent prognostic factor in alopecia areata, in addition to the well-known clinical prognostic factors. They may also be used to predict the response to treatment. (Korean J Dermatol 2007;45(2):111~118)

2원저 : 여성형 탈모에서 AP-FHG0604T의 유효성 및 안전성 평가에 관한 임상 연구

저자 : 신효승 ( Hyo Seung Shin ) , 이승호 ( Seung Ho Lee ) , 김동현 ( Dong Hyun Kim ) , 안지수 ( Jee Soo An ) , 권오상 ( Oh Sang Kwon ) , 은희철 ( Hee Chul Eun ) , 김규한 ( Kyu Han Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 119-126 (8 pages)

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Background: Hair loss is a very common disorder and the number of patients is known to be increasing. Female pattern hair loss (FPHL) is not only a medical problem but also a very severe psychosocial problem for many female patients. Anti-androgen drugs, mineral supplements and topical minoxidil have all been used for the treatment of FPHL. However they do not always achieve successful results and there is still much need for more effective therapy. Objective: The purpose of this 18-week, double-blind, placebo-controlled, randomized clinical trial was to investigate the efficacy and safety of a new topical agent, AP-FHG0604T, in the treatment of FPHL. Methods: A total of 33 women with FPHL (mean age: 33.4 years old) applied either a topical AP-FHG0604T solution (n=17), or placebo (vehicle for AP-FHG0604T solution; n=16) twice daily. Efficacy was evaluated by phototrichogram, investigator`s photographic and patient`s subjective assessments. All adverse effects were reported during the study. Results: After 18 weeks of therapy, topical AP-FHG0604T treatment showed a significant improvement compared to baseline values of total hair count, non-vellus hair count, and linear hair growth rate. In the placebo group, non-vellus hair count and ratio of anagen hair significantly decreased. The change rates of total hair count and non-vellus hair count in the AP-FHG0604T group were significantly higher than those in the placebo group. Neither investigator`s photographic assessments nor patient`s subjective assessments of hair growth showed statistically significant differences between the AP-FHG0604T group or the placebo group. Some patients who used AP-FHG0604T complained of local irritation during the study, but the irritation was so mild that they did not need any treatment for this. Conclusion: We conclude that AP-FHG0604T is a safe and efficient topical agent which can be used as another treatment of choice for FPHL, as shown by objective assessment with phototrichogram. (Korean J Dermatol 2007; 45(2):119~126)

3원저 : 기저세포암에서 국소 광역동요법의 치료 효과

저자 : 김영진 ( Young Jin Kim ) , 강희영 ( Hee Young Kang ) , 이은소 ( Eun So Lee ) , 김유찬 ( You Chan Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 127-133 (7 pages)

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Background: Photodynamic therapy has been reported to be useful in treating basal cell carcinoma. However, there have been no clinical trials for the treatment of basal cell carcinoma using photodynamic therapy in Korea. Objective: The purpose of this study was to evaluate the effectiveness and side effects of photodynamic therapy in the treatment of basal cell carcinoma. Methods: Photodynamic therapy, with a 630±50 nm light-emitting diode device and 20% 5-aminolevulinic acid was used to treat 12 lesions of basal cell carcinoma on 12 patients. The light intensity used was 100 mW/cm2 and the light dose was 120 to 280 joules/cm2. The depth of lesions ranged from 0.35 to 1.5 mm. Histopathologic subtypes consisted of 9 nodular, 1 micronodular, 1 infiltrating, and 1 superficial type. Results: Complete clearance was achieved in 2 of 12 lesions after 3 treatment sessions and 5 lesions after 4 treatment sessions. Overall, complete clearance was successful for 7 of 12 lesions (58%). Side effects were negligible in most patients, but two patients reported a moderate burning sensation in the first and second treatment sessions. Conclusion: Photodynamic therapy may be a useful alternative treatment therapy for basal cell carcinoma, especially for those lesions where existing treatment has recognized limitations. (Korean J Dermatol 2007;45(2):127~133)

4원저 : 연조직염 환자에서 피부 생검 조직 배양을 통한 원인균 검출률 향상에 관한 연구

저자 : 이재영 ( Jae Young Lee ) , 박석돈 ( Seok Don Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 134-139 (6 pages)

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Background: Staphylococcus aureus and group A streptococci are the most common etiologic agents in cellulitis, but occasionally many other bacteria are also identified. The positive rate of bacterial cultures taken from the skin lesion are low. Objective: This study aims to improve the positive culture rate in patients with cellulitis by using skin biopsy specimens in several kinds of media. Methods: Skin biopsy specimens taken from 54 patients with cellulitis were cultured in 4 functionally-different types of media (blood agar, MacConkey agar, chocolate agar, thioglycollate broth). Positive culture rates were evaluated in each medium and cultured bacteria were identified. Clinical characteristics were also studied, including age, sex, affected site, and history of previous treatment. Results: The sex ratio of males to females was 2.9 : 1 and mean age was 49 years. The most commonly-involved site was the lower extremities (42.6%), followed by the upper extremities (13.0%), head and neck (9.3%), and trunk (1.9%). Patients who had received previous antimicrobial treatment numbered 31 cases (57.4%). Of the 23 patients who had received no previous antimicrobial treatment, 13 patients (56.5%) had positive cultures. The most common pathogens were S. aureus and Streptococcus sp. (59.1%), but seven different genus of bacteria were also isolated from 9 patients (40.9%). Thioglycollate broth yielded a high positive culture rate (38.9%) among the 4 types of culture media. Conclusion: It is suggested that the bacterial culture of skin biopsy tissue from four functionally-different types of media is a useful method for improving positive bacterial culture rate in patients with cellulitis. (Korean J Dermatol 2007;45(2):134~139)

5원저 : Hydroxyproline의 안면부 주름 개선 효과에 관한 연구

저자 : 서기석 ( Kee Suck Suh ) , 최수영 ( Soo Young Choi ) , 김상태 ( Sang Tae Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 140-148 (9 pages)

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Background: Many treatment modalities for wrinkle reduction have been developed in the field of dermatology. Hydroxyproline plays a critical role in stabilizing the triple helix of collagen. The triple-helical conformation gives collagen most of its unique properties and is essential for normal fibrillogenesis. Objective: This study was performed to investigate the effect of hydroxyproline on the improvement of wrinkles in vitro and in vivo. Methods: Cultured fibroblasts and 25 human volunteers were used for in vitro and in vivo studies respectively. Hydroxyproline was administered to a fibroblast culture system and was also applied to periorbital wrinkle lesions twice daily for 12 weeks. The effect of hydroxyproline was examined by using an image analysis system with skin replica, and subjective and objective assessment of wrinkles were evaluated. Results: With the in vitro study, the number of cultured fibroblasts did not increase in the 10(-4), 10(-6) and 10(-8)ug/ml hydroxyproline groups compared to the control groups. Procollagen Type 1 C-peptide of cultured fibroblasts did increase in the 10(-8)ug/ml hydroxyproline group compared to the control group (p<0.05). With the in vivo study, there was a significant decrease in wrinkles at 8 and 12 weeks after application in the 0.5% hydroxyproline applied group compared to the control group (p<0.001). In the subjective visual assessment by the investigator and the subjects at 8 and 12 weeks after application, the 0.5% hydroxyproline treated group showed a significant improvement of wrinkles and more personal satisfaction than the control group (p<0.05). Conclusion: 0.5% hydroxyproline had an effect in vivo and in vitro on wrinkle improvement. It is suggested that hydroxyproline might be a candidate compound for treatment or reduction of wrinkles. (Korean J Dermatol 2007;45(2):140~148)

6원저 : 피부 악성 흑색종의 임상 및 병리조직학적 소견

저자 : 박경덕 ( Kyung Duck Park ) , 이석종 ( Seok Jong Lee ) , 이원주 ( Weon Ju Lee ) , 김도원 ( Do Won Kim ) , 정호윤 ( Ho Yun Chung ) , 조병채 ( Byung Chae Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 149-158 (10 pages)

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Background: Malignant melanoma is the leading cause of death among skin cancers in western countries. The incidence of melanoma has been steadily increasing over the last 20 years, and age and sex distribution, anatomic location, clinicopathologic subtypes, and prognostic factors of malignant melanoma are also well known. However, various clinicopathologic aspects such as incidence, clinicopathologic subtypes and tumor behaviors are quite different in Asian and black skin. Objective: The purpose of this study was to investigate the clinicopathologic behavior and statistics of malignant melanoma patients of Kyungpook National University Hospital, and to evaluate prognostic predictors. Methods: Of the 97 out of 103 patients diagnosed with malignant melanoma at the Department of Dermatology of Kyungpook National University Hospital over a 14 year period (l992~2006), we analyzed mean age of onset, gender, tumor location, duration, tumor number, color, tumor thickness, Clark`s level, pathologic ulceration, tumor-infiltration lymphocytes, clinicopathologic subtype, and clinical AJCC stage. Univariate analysis and multivariate analyses for survival, according to clinical and histologic tumor settings, were performed by means of the Cox proportional hazard model. Survival curves were plotted by the Kaplan-Meier method. Results: Ninety-seven melanomas were identified and analyzed by both clinical behavior and pathology. Of these, 44 were male and 53 were female patients and the mean age was 59.7 years. Most of the tumors were located on the hands and feet. Thin melanoma was the most common tumor and histologic ulcerations were observed in 37 out of 81 patients who were available for evaluation. For tumor-infiltrating lymphocytes (TIL), 22 out of 76 patients were confirmed with TIL in the pathologic review. Acral lentiginous melanoma was the most common type, followed by nodular melanoma, superficial spreading melanoma, and lentigo maligna melanoma. Univariate analysis for overall survival of melanoma revealed that thickness of tumor, the presence of ulceration, the presence of tumor-infiltrating lymphocytes, clinicopathological subtype, and clinical stage have a tendency for a poorer prognosis. Multivariate analysis demonstrated that advanced stages (III and IV) and tumor thickness were the independent risk factors for poor prognosis. Conclusion: Few similar large studies have been conducted to assess the prognostic factors of melanoma in Korea. Therefore, further prospective studies are needed to assess the biological behavior of malignant melanoma, of which the incidence has been steadily increasing in Korea. (Korean J Dermatol 2007;45(2):149~158)

7원저 : 성인 아토피피부염 환자에서 삶의 질 평가의 임상적 유용성

저자 : 이희정 ( Hee Jung Lee ) , 박창욱 ( Chang Ook Park ) , 이주희 ( Ju Hee Lee ) , 이광훈 ( Kwang Hoon Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 159-164 (6 pages)

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Background: Quantification of quality of life (QOL) related to disease severity is important in patients with atopic dermatitis (AD), because the assessment provides additional information to the traditional objective clinical scoring systems. Objective: We evaluated the association between QOL and severity scoring systems of AD. Methods: We assessed QOL, clinical severity scores, and total IgE in peripheral blood in 41 AD patients at our dermatology clinic over an 8 month period. QOL was assessed at two visits with a monthly interval by a dermatology-specific questionnaire (Dermatology Life Quality Index (DLQI)). Eczema Area and Severity Index (EASI) and Scoring of Atopic Dermatitis (SCORAD) was used to measure disease severity. Visual analogue scale (VAS) of pruritus and loss of sleep (LOS) were also recorded. Results: The mean DLQI was 11.6. For DLQI the dimension with the highest score was 26, and the lowest score was 2. DLQI did not correlate with EASI at visit 1, but correlated well with EASI at visit 2. Changes of DLQI in each patient between visits 1 and 2 were significant (p<0.05) and positively correlated with the severity scoring (EASI, SCORAD). In addition, the sum of VAS of pruritus and loss of sleep a correlated well with the DLQI and EASI at each visit. Conclusion: AD has a great impact on QOL of patients. Although the DLQI is known as an excellent method of measuring QOL in patients with dermatologic disease, correlation between DLQI and disease severity was not definite. However, changes of DLQI during follow-up significantly correlated with clinical course in each patient. Therefore, DLQI can be an important parameter when evaluating the disease course in AD patients. (Korean J Dermatol 2007;45(2):159~164)

8증례 : BCG 접종 후 발생한 습진양 반응 2예

저자 : 김지웅 ( Jee Woong Kim ) , 최우석 ( Woo Seok Choi ) , 박현수 ( Hyun Su Park ) , 최정철 ( Jung Chul Choi ) , 장상재 ( Sang Jai Jang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 165-167 (3 pages)

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The adverse effects of BCG vaccination span diversely from systemic to local reactions. However, the adverse effects of BCG vaccination on the skin are rare and these can appear as non-specific or specific skin reactions. We experienced two cases of non-specific skin reaction, which occurred on a vaccine-injected site. Eczematous lesions with the clinical and pathological findings have not previously been report in the English dermatologic literature. Herein, we present two interesting cases of non-specific skin reactions from dermatological complications of BCG vaccination. (Korean J Dermatol 2007;45(2):165~167)

9증례 : 후경부 섬유종 1예

저자 : 강태원 ( Tae Won Kang ) , 이상은 ( Sang Eun Lee ) , 김수찬 ( Soo Chan Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 168-170 (3 pages)

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Nuchal fibromas are rare, benign fibrous proliferations characterized by hypocellular dense collagen in the dermis and the subcutaneous fat layer. Nuchal fibromas usually develop in the posterior neck as a solitary, soft tissue mass. Herein, we report a case of a nuchal fibroma presenting on the posterior neck of a 60-year-old male. An excisional biopsy was done and showed haphazardly-arranged, dense collagen infiltration throughout the dermis and the subcutaneous fat layer. Moreover, fat lobules, adnexas and nerve fibers were entrapped by collagen bundle infiltrations. Dermatologists should include nuchal fibrma in the differential diagnosis of patients with a posterior neck mass. (Korean J Dermatol 2007;45(2):168~170)

10증례 : 백혈구 파쇄성 혈관염의 경구 스테로이드 치료 중 발생한 화농성 근염 1예

저자 : 신효승 ( Hyo Seung Shin ) , 원종현 ( Chong Hyun Won ) , 조소연 ( So Yun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 171-174 (4 pages)

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Pyomyositis is an acute, suppurative bacterial infection of striated muscle. It occurs primarily, and not from contiguous infection. It is considered rare in temperate climates. There has been no report of pyomyositis in the Korean dermatologic literature to date. We report a case of pyomyositis which developed in a 53-year-old male. The patient was admitted for the treatment of cutaneous leukocytoclastic vasculitis on his entire body. He was treated with oral corticosteroids for approximately three weeks. The skin condition did show improvement; however, the patient developed a persistent fever and a newly-found mass on the right upper back. The mass was diagnosed as an abscess, replacing the striated muscles of the back by sono-guided needle aspiration. After surgical intervention and IV antibiotic treatment, the symptoms and mass on the back disappeared. We speculate that the underlying skin condition and long-term use of oral corticosteroids predisposed the patient to pyomyositis. (Korean J Dermatol 2007;45(2):171~174)

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주제별 간행물
간행물명 수록권호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 4호 ~ 58권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 1호 ~ 46권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 3호 ~ 58권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 2호 ~ 32권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 2호 ~ 58권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호

프로그램북(구 초록집)
71권 1호 ~ 71권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 9호 ~ 57권 9호

프로그램북(구 초록집)
71권 2호 ~ 71권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 6호 ~ 31권 6호

프로그램북(구 초록집)
71권 2호 ~ 71권 2호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 6호 ~ 31권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 3호 ~ 45권 3호

KCI등재 SCOUPUS

대한피부과학회지
57권 8호 ~ 57권 8호

KCI등재 SCI SCOUPUS

Annals of Dermatology
31권 5호 ~ 31권 5호

한국피부장벽학회지
21권 1호 ~ 21권 1호
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

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