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대한피부과학회> 대한피부과학회지> Carbamazepine에 의해 발생된 것으로 사료되는 항경련제 과민성 증후군 1예

KCI등재SCOUPUS

Carbamazepine에 의해 발생된 것으로 사료되는 항경련제 과민성 증후군 1예

Short Report : A Case of Anticonvulsant Hypersensitivity Syndrome Induced by Carbamazepine

박석열 ( Park Seog Yeol ) , 김주용 ( Kim Ju Yong ) , 김창욱 ( Kim Chang Ug ) , 김병천 ( Kim Byeong Cheon ) , 이규석 ( Lee Gyu Seog )
  • : 대한피부과학회
  • : 대한피부과학회지 42권4호
  • : 연속간행물
  • : 2004년 04월
  • : 523-526(4pages)

DOI


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Anticonvulsant hypersensitivity syndrome is a life threatening immunologic reaction of anticonvulsants therapy such as phenytoin, phenobarbital, or carbamazepine, characterized by multiple abnormalities ssuch as fever, rash, lymphadenopathy, acute hepatocellular injury, leukocytosis, and eosinophilia.  We report a case of anticonvulsant hypersensitivity syndrome thought to be caused by the use of carbamazepine in a 65-year-old male. He developed erythematous skin eruption four weeks after beginning therapy with carbamazepine. The clinical, laboratory and histologic findings of this patient were compatible with anticonvulsant hypersensitivity syndrome.

UCI(KEPA)

I410-ECN-0102-2009-510-002685551

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2020
  • : 9446


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1원저 : 무모생쥐 피부에 1320 nm Nd:YAG 레이저와 long-pulsed 1064 nm Nd:YAG 레이저의 조사 효과

저자 : 김주용 ( Kim Ju Yong ) , 정현주 ( Jeong Hyeon Ju ) , 김동석 ( Kim Dong Seog ) , 이규석 ( Lee Gyu Seog )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 385-391 (7 pages)

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Background: The treatment of facial rhytides has traditionally centered around methods that involve removal of the epidermis and superficial dermis, encouraging the production of a new epidermis with collagenesis and remodelling. But all of the resurfacing techniques lead to postoperative complications such as oozing, bleeding, infections, "downtime" as the skin begins to reepithelialize, and the occasional incidence of posttreatment, postinflammatory pigmentary changes. 1320㎚ and 1064㎚ wavelengths are nonspecifically absorbed in the human dermis and are unique for its significant horizontal scattering. These wavelengths, when used for localized facial areas, have been shown to produce new collagen formation and improvement in the quality of treated skin.  Objective: The purpose of this study was to examine the effect of 1320㎚ Nd:YAG laser and long-pulsed 1064㎚ Nd:YAG laser irradiation on hairless mouse skin and rat skin.  Methode: In this study, the effect of 1320㎚ Nd:YAG laser and long-pulsed 1064㎚ Nd:YAG laser irradiation were examined by Hematoxylin and eosin (H&E) stain, Masson`s trichrome stain, immunohistochemical stain for type I collagen and dot-blot hybridization for α1(Ⅰ) procollagen mRNA.  Results: IN the H&E stain, Masson`s trichrome stain, and immunohistochemical stain of the hairless mouse skin, the number of collagen fibers with a greater density of fibers increased, compared to the non-irradiated controls on both the 1320㎚ Nd:YAG laser and the long-pulsed 1064㎚ Nd:YAG laser. In the dot-blot hybridization in the hairless mouse, levels of α1(Ⅰ) procollagen mRNA were increased 3.0-fold, 4.8-fold and 5.2-fold at each 1 week 4 weeks and 12 weeks after irradiation in 1320㎚ Nd:YAG laser and 1.8-fold and 2.1-fold at each 4 weeks and 12 weeks after irradiation in long-pulsed 1064㎚ Nd:YAG laser, compared to the non-irradiated controls. But in the 1320㎚ Nd:YAG laser irradiation on the rat, there is no significant change in the number and density of collagen fibers, compared to the non-irradiated controls.  Conclusion: These results indicate that the 1320㎚ Nd:YAG laser and the long-pulsed 1064㎚ Nd:YAG laser may be a powerful up-regulator of collagen synthesis through significant dermal damage and the 1320㎚ Nd:YAG laser is better than the long-pulsed 1064㎚ Nd:YAG laser for collagen synthesis. Therefore, the 1320㎚ Nd:YAG laser can be more effective clinically than the long-pulsed 1064㎚ Nd:YAG laser for the treatment of photodamaged skin.  (Korean J Dermatol 2004;42(4):385~391)

2원저 : 베커 모반의 ND:YAG 레이저 치료 효과에 대한 임상 평가

저자 : 김현웅 ( Kim Hyeon Ung ) , 서영준 ( Seo Yeong Jun ) , 이증훈 ( Lee Jeung Hun ) , 박장규 ( Park Jang Gyu ) , 남인환 ( Nam In Hwan )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 392-397 (6 pages)

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Background: Xanthelasma palpebrarum does not regress spontaneously, its appearance is often seen as cosmetically disturbing. Treatment of xanthelasrna palpebrarum may prove difficult due to its delicate location at the periorbit and sometimes its extensive dimension. Treatments include excision, electrodesiccation, chemical cautery and laser surgery.  Objective: This study was designed to evaluate the effect of a CO₂laser for the treatment of xanthelasma palpebrarum.  Methods: Twenty patients with a total of 56 xanthelasma lesions, were treated with a CO₂laser. The Follow-up period of observation was between 12 and 84 months.  Results: All lesions could be removed completely with a single laser treatment. Only transient pigmental change (hypopigmentation 1/20, hyperpigmentation 1/20) was observed without scarring. 8 patients developed a recurrence of xanthelasma.  Conclusion: The CO₂laser represents an effective means for treating xanthelasma, but recurrence is common. (Korean J Dermatol 2004;42(3):250~255)

3원저 : 포도구균성 열상 피부 증후군 25예의 임상적 분석에 의한 재분류

저자 : 강정대 ( Kang Jeong Dae ) , 박석돈 ( Park Seog Don )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 398-405 (8 pages)

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Background: Dermatofibromas are common benign tumors which occur in the skin. They have been divided into "fibrous" lesions, composed entirely of almost entirely of fibroblasts and collagen, and "cellular" lesions composed to a significant degree of phagocytic cells with the appearance of histiocytes. A cellular variant characterized by increased cellularity, storiform arrangement, larger size, and location in the deep dermis, often with extension into the superficial subcutaneous tissue may be difficult to differentiate from dermatofibrosrcoma protuberans. There is an incessant controversy over the histogenesis of dermatofibromas, although many authors consider that these tumors derive from primitive mesenchymal cells. The recent development in immunohistochemical staining technology and ultrastructural study revealed various cellular proliferation in the lesion, including fibroblast, histiocyte and myofibroblast.  Objective: Our purpose was to study by immunohistochemistry the defferences between fibrous and cellular dermatofibromas and to find the relationship between the myofibroblast and the histogenesis of dermatofibroma.  Methods: We will select 36 cases of dermatofibromas which include 27 fibrous and 9 cellular types. We have studied the immunophenotype of 36 dermatofibromas using antibodies against vimentin, smooth muscle actin, desmin, CD34, factor XⅢa, CD68 and MMP 11.  Results: All dermatofibromas were positive for vimentin, smooth muscle actin, and factor XⅢa, but negative for desmin and CD34. All cellular type were positive for CD68, but 24/27 of the fibrous type were positive for CD68. MMP 11 was positive in 6/9 of the cellular type and 25/27 of the fibrous type. The degree of staining for vimentin, factor XⅢa, CD68, and MMP 11 was not different in both types. But the degree of staining for smooth muscle actin in the fibrous type was higher than in the cellular type.  Conclusion: The differences in the degree of staining for smooth muscle actin and the positivity for CD68 suggest the possibility of a different differentiation of dermatofibroma between cellular and fibrous types. The prominent vimentin and smooth muscle actin immunoreactivity and desmin non-reactivity may suggest that the myofibroblast may play a role, in part, for developing dermatofibromas. Further investigations with ultrastructural study using electron microscopy and double/triple immunohistochemical staining would be necessary.  (Korean J Dermatol 2004;42(3):256~263)

4원저 : A형 보툴리눔 독소를 이용한 원발성 겨드랑이 다한증 치료 후 피부장벽 기능과 삶의 질 변화에 관한 연구

저자 : 황규철 ( Hwang Gyu Cheol ) , 김일환 ( Kim Il Hwan )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 406-412 (7 pages)

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Background: Quality of life is a broad concept that incorporates all aspects of an individual`s existence. Psoriasis is a chronic relapsing disease of the skin and may produce a range of quality of life impacts, as complex as those from a more debilitating and life-threatening disease. However, the association between quality of life in psoriasis patients and their clinical characteristics has not yet been investigated in Korea.  Objective: The purpose of this study is to compare the quality of life in patients with psoriasis and healthy controls by using the WHO Quality of Life (QOL) Scale. This evaluates the domains of physical health, psychological health, social relationship and the environment, to assess the quality of life in patients with psoriasis by using the generic (WHOQOL) and dermatology-specific questionnaires (Skindex-29). The relationship between their quality of life and their clinical characteristics, comprising; onset, sex, age, education, duration of symptoms, severity, stress, anxiety and depression will be investigated.  Methods: Seventy one patients with psoriasis and twenty nine healthy controls were recruited in this study all of whom completed the WHOQOL Scale. The total scores and the scores of the domains of the WHOQOL Scale in both groups were compared. Correlation analysis and multiple regression analysis were performed to examine the relationship between quality of life and the clinical characteristics in patients with psoriasis.  Results: The total WHOQOL scores and all domain scores, except those of the environmental domain, of the WHOQOL scale in patients with psoriasis were lower than those of the healthy controls. scores for the Beck Depression Inventory (BDI), the Beck anxiety Inventory (BDI) and the Psoriasis Life Stress Inventory (PLSI) were all high. The high self reported severity, long duration, high PLSI score and low education levels all showed significant correlation with low QOL. Of these characteristics, the BDI, BAI, PASI, and the self reported severity showed strong association with QOL. Stepwise multiple regression analysis revealed the BDI score, PASI score, and education level were influencing factors on QOL scores.  Conclusion: The quality of life in patients with psoriasis was poorer than that of the healthy controls. The association between QOL and the self reported severity was stronger than the QOL and the PASI score. The severity of depression and stress were the most important predictors on QOL (Korean J Dermatol 2004;42(3):264~271)

5원저 : Sodium lauryl sulfate 자극에 대한 알로에 베라 겔 (Aloe vera gel)의 항자극 효과에 대한 연구

저자 : 한희진 ( Han Hui Jin ) , 박천욱 ( Park Cheon Ug ) , 이철헌 ( Lee Cheol Heon ) , 유종우 ( Yu Jong U )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 413-419 (7 pages)

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Background: Ota`s nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary.  Object: The aim of this study was to document the clinical and histopathological features of Ota`s nevus.  Methods: We examined 299 patients with Ota`s nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota`s nevus into 4 types according to Tanino`s classification and histologically into 5 types based on the pattern of pigmentation.  Results:  1. The ratio of male and female was 1:3.  2. The peak age of onser was at birth (28.4%) and puberty (24.8%).  3. seasonal variation was observed with distinct aggravation in the summer (60%).  4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of nevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis.  5. The aggravating factors were sunlight (35.8%), emotional stress (21.0%), menstruation (12.6%), cold expand (9.5%), pregnancy (9.5%), fatigue (9.5%) and chemical agents (2.1%).  6. The color of lesions were blue black (36.8%), brown (34.8%), dark brown (16.1%) and slate (11.0%).  7. All cases were classified according to Tanino`s methods: type Ia (23.1%), type Ⅰb (20.1%), type Ⅱ (26.7%), type Ⅲ (9.4%), type Ⅳ(20.7%).  8. the histological subtypes of Ota`s nevus were classified as: the superficial type (35.6%); the middermis type (5.9%), the superficial-middermis type (18.6%); the mid-lower dermis type (2.7%); the diffuse type was composed of the superficial dominant type (19.7%), the middermis dominant type (4.8%), the dispersed (true diffuse) type (12.2%) and the deep dominant type (0.5%).  9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color; the deep dominant type had 1 case of blue black color.  Conclusion: The histological reclassification of Ota`s nevus may be very useful in making a therapeutic prognosis of the disease. (Korean J Dermatol 2004;42(3):272~280)

6원저 : 소아 및 중증 원형 탈모증 환자에 대한 Cyclosporin-A 도포요법의 치료효과

저자 : 이찬우 ( Lee Chan Woo ) , 심승주 ( Sim Seung Ju ) , 임정준 ( Im Jeong Jun ) , 이병건 ( Lee Byeong Geon ) , 송기훈 ( Song Ki Hoon ) , 김기호 ( Kim Ki Ho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 420-425 (6 pages)

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Background: Prolonged exposure of topical and systemic corticosteroid to skin can result in well-recognized cutaneous abnormalities including cutaneous atrophy, easy bruisibility, increased skin fragility, and increased risk of infection. Skin barrier impairment is also reported as a steroid-induced side effect. A major function of the skin is the formation of a permeability barrier between the external milieu and the organism. Recent studies have shown that chronic corticosteroid negatively impacts epidermal barrier function. As well as this topical corticosteroid not only has antiproliferative actions but also inhibits the difterentiaion of the epidermis, resulting in only has antiproliferative actions but also inhibits the difterentiation of the epidermis, resulting in structural defects in the epidermis.  Object: We wanted to determine whether high dose systemic steroid injection would display adverse effects, specifically on; epidermal functions, permeability barrier homeostasis and stratum corneum integrity and cohesion. The basis for such changes was also to be determined.  Material and Methods: Systemic steroid was administered by injection each hairless mouse, 8-10 week of age, intraperitoneally with 0.3㎎ triamcinolone acetonide, two times per week for five weeks. For the controlled hairless mice, 0.9% normal saline was administered by the same method of injection. Every week, transepidermal water loss (TEWL) was checked and skin biopsies were taken. Skin specimens were prepared for electron microscopy using both 0.25% ruthenium tetroxide and 4% osmium tetroxide postfixation. For light microscopy staining hematoxylin-eosin and ion capture cytochemistry was used.  Results: The results were as follows;  1. From about 1 week onwards, high dose systemic steroid usage produced visible cutaneous changes and significantly increased the TEWL in the group of 0.3 ㎎ triamcinolone acetate injected hairless mice compared with the control.  2. Light microscopic observations of the steroid-injected hairless mice showed gradual thinning of the epidermis from about 2 weeks onwards, compared with the control. Loss of stratum corneum was also observed in the steroid injected hairless mice.  3. The ruthenium tetroxide staining of high dose systemic steroid treated specimens revealed that the lipid bilayer was impaired and fragmented from about 3 weeks. Intercellular spaces were widened and the lipid bilayer either disappeared or showed damage when compared with the control.  4. From about 3weeks onwards. electron microscopic studies revealed, not only a marked decrease in the number of lamellar bodies, but also an abnormal transformation of lamellar bodies in the steroid injected hairless mice compared with the control.  5. Throughout the five weeks, the calcium gradient gradually disappeared in the 0.3㎎ triamcinolone injected hairless mice compared with the control. Consequently, high dose systemic steroid use results in barrier dysfunction and morphological abnormalities.  (Korean J Dermatol 2004;42(3):281~289)

7원저 : 경기 안산 지역 소아 피부 질환의 기술 역학적 고찰(1998-2002)

저자 : 이호섭 ( Lee Ho Seob ) , 김일환 ( Kim Il Hwan )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 426-434 (9 pages)

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Background: Pediatric dermatoses can be regarded as a different disease because a child`s skin differs from an adult`s skin in many aspects.  Objective: The purpose of this study was to evaluate the distribution of pediatric drematoses in the Kyonggi-do Ansan area and to compare the results with previous reports.  Methods: New Patients under 15 years of age who visited Korea University Ansan hospital from 1998 to 2002 were reviewed using their clinical records.  Results: The study results are summarized as follows;  1. Among the 25,839 new patients, 7,255 (28.1%) were pediatric patients with a male to female ratio of 1:1.12.  2. In the age distribution, the number of patients decreased with increasing age.  3. The Peak incidence occurred in August, July and January in decreasing order. The incidence was more prominent in summer and winter.  4. The ten most common dermatoses were atopic dermatitis, viral wart, contact dermatitis, urticaria, molluscum contagiosum, dermatophytosis, vitiligo, hemangioma, nevocellular mevus, and acne in decreasing order.  5. In the annual distribution, dermatoses showing an increasing tendency were identified as atopic dermatitis, viral wart and acne, whereas dermatophytosis showed a decreasing tendency.  Conclusion: Compared to previously published reports, the distribution of dermatoses was different and the proportion of pediatric patients had decreased according to the reduction of the pediatric population. (Korean J Dermatol 2004;42(4):426~434)

8원저 : 쥐의 진피 섬유모세포에서 Sodium-dependent Vitamin C Transporter의 발현

저자 : 홍창권 ( Hong Chang Gwon ) , 최성욱 ( Choe Seong Ug ) , 전병환 ( Jeon Byeong Hwan ) , 서성준 ( Seo Seong Jun ) , 김명남 ( Kim Myeong Nam ) , 노병인 ( No Byeong In )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 435-442 (8 pages)

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9증례 : 모종, 악성 모낭종, 모아세포종을 동반한 피지선 모반

저자 : 노윤우 ( No Yun U ) , 윤태영 ( Yun Tae Yeong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 443-446 (4 pages)

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Nevus sebaceus is located on the scalp or the face as a single lesion and is already present at birth, various types of appendage tumor may develop secondarily within the lesion of the nevus sebaceus. A syringocystadenoma papilliferum is the most common secondary benign tumor that has been found in 8% to 19% of the lesion of nevus sebaceus. The malignant carcinoma and malignant eccrine poroma. The combination of a variety of tumor was found in the lesion of nevus sebaceus.  We report a case of nevus sebaceus in a 66-year-old male associated with trichilemmoma, trichilemmal carcinoma and trichoblastoma. (Korean J Dermatol 2004;42(4):443~446)

10증례 : 편평태선/홍반성 루푸스 중복증후군 1예

저자 : 성기한 ( Seong Gi Han ) , 이상민 ( Lee Sang Min ) , 이희상 ( Lee Hui Sang ) , 이숙경 ( Lee Sug Gyeong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 42권 4호 발행 연도 : 2004 페이지 : pp. 447-451 (5 pages)

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Lichen planus(LP) and lupus erythematosus(LE) may occur infrequently as an overlap syndrome. The term comprises a heterogenous group of patients who have clinical, histological and/or immunopathological characteristics of both diseases at the same time.  We report a case of LP/LE overlap syndrome in a 42-year-old man who has had a red to violet colored patch with atrophy and telangiectasia on the left arm for 2 years. The biopsy of the left arm showed histological features consistent with LP and LE at the same lesion. Direct immunofluorescence also showed features consistent with LP and LE at the same lesion.  (Korean J Dermatol 2004;42(4):447~451)

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주제별 간행물
간행물명 수록권호

KCI등재 SCOUPUS

대한피부과학회지
58권 9호 ~ 58권 9호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 6호 ~ 32권 6호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 5호 ~ 32권 5호

KCI등재 SCOUPUS

대한피부과학회지
58권 8호 ~ 58권 8호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 3호 ~ 46권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 7호 ~ 58권 7호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 4호 ~ 32권 4호

KCI등재 SCOUPUS

대한피부과학회지
58권 6호 ~ 58권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 2호 ~ 46권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 5호 ~ 58권 5호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 4호 ~ 58권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 1호 ~ 46권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 3호 ~ 58권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 2호 ~ 32권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 2호 ~ 58권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호
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자료제공: 네이버학술정보

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