The Job syndrome is a primary immunodeficiency disorder characterized by markedly elevated serum IgE levels, recurrent severe infections of the skin and sinopulmonary tract, including staphylococcal pneumonias, chronic eczematoid dermatitis, coarse facial features, and mild eosinophilia. In 1966, Davis two patients with severe eczema, chroic sinopulmonary infections, et al discribed and recurrent staphylococcal abscesses originally. The reason for immunocompromise in the Job syndrome remains unclear, but a chemotactic defect in neutrophils has been described, We have experienced a case of Job syndrome in a 9-year-old suffered from severe recurrent multiple infections since 2 month treatment with thymopentin, she was improved clinically, A brief review of related literature is presented.