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대한면역학회> 대한면역학회지> 집먼지 진드기에 감작된 마우스에서 전신성 과민반응 유발과 면역학적 관점

집먼지 진드기에 감작된 마우스에서 전신성 과민반응 유발과 면역학적 관점

Induction of Active Systemic Anaphylaxis and Immunological Aspects in Mice Sensitized with House Dust Mite

이봉기(Bong Ki Lee) , 이숙이(Sook Yi Yi) , 장윤수(Yun Soo Jang) , 박중원(Chung Won Park) , 홍천수(Chun Soo Hong)
  • : 대한면역학회
  • : 대한면역학회지 20권2호
  • : 연속간행물
  • : 1998년
  • : 163-170(8pages)

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We have used BALB/c mice as an animal model for the study of anaphylactic hypersensitivity to the house dust mite. For the sensitization, BALB/c mice were injected with a single dose of extracts of Oermatophagoides farinae (D. pa) or Dermatophagoides pteronyssinus (D. pt) mixed with adjuvants (aluminum hydroxide and Bordetella pertussis) intraperitonealy. On days of 15, 30, and 60 after the sensitization, the mice received a challenge dose of the same allergen intravenously to induce anaphylactic shock. The hypersensitivity reactions were scored by anaphylactic shock. And various immunological parameters, including cytokines and immunoglobulin isotypes, were studied in relation with the shock. A high level of anaphylactic shock was produced in the mice by both of the allergens, D, fa and D, pt, at 15 and 30 days after sensitization. In vitro Ag specific proliferative reponses of spleen cells from D. pt treated mice (D. pt mice) was six times higher than those from O. fa treated mice (O. fa mice). Regardless the differences in antigens, the production of IFN-r by spleen cells from D. pt mice or O. fa mice was equally high at 15 days after sensitization. However, the ability to produce IFN-r by the spleen cells from D, pt mice was three times higher compared to that from D. fa mice. The production of IL-4 by the spleen cells was enhanced slightly but not significant in both groups. In studies of the allergen-specific immunoglobulin isotypes in the sera of the mice, the level of IgE in both groups was enhanced slightly but not significant. In contrast, the level of IgG subtypes were increased in both groups. When the levels of IgG were compared by subtypes, the level of IgG1 increased significantly on day 15 when the anaphylactic shock score was maximized in both groups. Increase in IgG2a level at the day was not significant, instead, asignificant increase in IgG2 levels was observed on day 60 after sensitization when the anaphylaxis was almost discontinued. Although a higher level of IgG3 was examined on day 15 and 30 in D. pt mice and on day 60 in D, fa mice, anaphylaxis was not appeared to be associated with the levels of IgG3 in this study. The IgG1, rather than IgE, was assumed to the major factor involved in the anaphylactic response observed in this experiment. In conclusion, BALB/c mice would be an animal model for the study of anaphylactic hypersensitivity to D. fa or D, pt., which might be an essential tool for the future development of immuno-therapeutic agents.  Korean J. Immunol. 20, 2: 163-170, 1998

UCI(KEPA)

I410-ECN-0102-2009-510-004783830

간행물정보

  • : 의약학분야  > 미생물학
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  • : 계간
  • : 1015-6453
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  • : 학술지
  • : 연속간행물
  • : 1983-2000
  • : 866


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1Tautomycetin 의 T 세포특이적인 면역억제효과

저자 : 이흥규(Heug Kyu Lee) , 조경민(Kyung Min Cho) , 전형식(Hyoung Sik Chun) , 손혁진(Hyeog Jin Son) , 이상규(Sang Kyou Lee)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 85-90 (6 pages)

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T cell activation is a critical event for initiation and regulation of immune responses and inhibitors of such signaling pathways are clinically useful for the treatment of patients received allogratt and autoimmune disease. In the course of screening soil microorganisms from the forest of Cheju island in Korea for new immunosuppressive agent, one of Streptomyces species (CK-95441) was found to produce a new immunosuppressant, tautomycetin which also had antifungal activity. Tautomycetin showed the inhibition of T cell proliferation in murine mixed lymphocyte reaction (MLR) and T cell activation induced by concanavalin A. Tautomycetin also blocked the induction of IL-2 gene expression which was examined in Jurkat TAg cell line in which multiple NFAT-binding sites and minimal IL-2 promoter drive the production of B-galactosidase. Also, the level of inhibition in activation-induced IL-2 receptor expression by tautomycetin was greater than those by cyclosporin A measured by flow cytometry. But, Fas ligand-induced apoptosis in Jurkat cells was unaffected by tautomycetin which was measured by DNA fragmentation assay. These results suggested that tautomycetin will be able to be used as a potent immunosuppressive drug following organ transplantation. Korean J. Immunol. 20, 2: 85-90, 1998

2Jurkat T 세포의 Apoptosis 신호전달 경로에서 Ich-1 과 Ich-1 의 기능

저자 : 이상규(Sang Kyou Lee) , 심재혁(Jae Hyuck Shim) , 김현정(Hyun Jung Kim) , 임정희(Jung Hee Lim)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 91-99 (9 pages)

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Human caspase-2, Ich-1 (Ice and Ced-3 homolog), has two different forms of mRNA species derived from alternative splicing, which encodes Ich-1 and Ich-1s. Ich-1v which induces apoptosis is antagonist of Ich-1s which suppresses Rat-1 cell death by serum deprivation. To investigate functions of Ich-1 and Ich-1s in T celi apoptosis, the fusion DNA constructs were made with the ecto and transmembrane of CDB and Ich-lv or Ich-1s and CDS-Ich-1 or CD8-Ich-1s chimeric protein was transiently expressed on Jurkat T cells. Tyrosine phosphorylation of intracellular proteins was induced in these transfectans when activated shortly by anti-CDB Ab. CDB-Ich-li transfectant in serum-rich condition and CDB-Ich-ls transfectant in serum-deprived condition underwent apoptosis when treated with anti-CDS Ab or incubated with NIH3T3 cells expressing stably Fas-L on their surface. We also made six antisense DNA constructs which could specifically inhibit the expression of Ich-1v, Ich- 1s, and then they were transiently transfected into Jurkat T cell. The overexpression of both of the antisese- Ich-1 against N-terminal 42 bp and against C-terminal 366 bp inhibited apoptosis through Fas signalling. But, when three different forms of antisense-Ich-1s were overexpressed in their transfectants, antisense-DNA against N-terminal 197 bp increased knd the one against C-terminal 66 bp inhibited apoptosis, instead the full size of antisense-DNA did not give any effects on apoptosis through Fas pathway.  Korean J. Immunol. 20, 2: 91-99, 1998

3TGF-B1 유전자 도입된 EL4 세포의 in vitro 와 in vitro 와 in vivo 특성 연구

저자 : 이정희(Jung Hee Lee) , 유진수(Jin Su Yoo) , 이기종(Ki Jong Rhee) , 송민형(Min Hyoung Song) , 한원교(Won Kyo Han) , 이민철(Min Chul Lee) , 김평현(Pyeung Hyeun Kim)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 101-108 (8 pages)

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Transforming growth factor-B1 (TGF-B1) is well known to be one of the most potent Immunosuppressive cytokines. To determine whether TGF-B1 secreted in the latent form can be immunoregulatory, TGF-B1 cDNA driven by the human -actin promotor was transfected into a murine thymoma cell line, EL4 cells. The transfectants (ELJ4) secreted a latent torm of TGF-B1 at a concentration of 5 ng/ml under the influence of TPA. Transfected TGF-b1 transcripts was readily detected by RT-PCR in ELJ4 cells regardless of the presence of TPA, but not in EL4 cells. In addition, we found the degree of Thy-B1 expression, IL-2 secretion and the proliferation rate are not altered by the transfection. Finally, EL4 and ELJ4 cells were injected into C57BU6 mice (syngenic strain), subcutaneously. Tumor cell masses derived from both cell populations survived longer than 1 wk, and the size of tumor derived from ELJ4 was three times larger (2.5 cm of diameter) than that from EL4. Virtually, there was no histopathological difference between two tumors. Taken together, the results from the present study indicates that EL4 thymomas transfected with TGF-1 secretes a latent form of TGF-B1 which may suppress host immune defence system.  Korean J. Immunol. 20, 2: 101-108, 1998

4Anti-DNA 단클론 항체에 대한 Anti-Idiotype 단클론 항체의 생산

저자 : 권명희(Myung Hee Kwon) , 강재승(Jae Seung Kang) , 신호준(Ho Joon Shin) , 장영주(Young Ju Jang) , 박선(Sun Park) , 이미리나(Mi Lli Na Lee) , 김형일(Hyung Il Kim)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 109-117 (9 pages)

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It has been thought that autoimmune diseases like systemic lupus erythematosus and rhumatoid athritis are closely associated with anti-DNA antibodies (Abs). In studies of the control for anti-DNA Ab generation, an understanding of the regulatory mechanisms by anti-idiotypic Abs that influence the production of anti- DNA Abs would be facillitated by the availability of the hybridomas producing the pairs of DNA-specific and anti-DNA's idiotope-specific monoclonal antibodies (mAbs). We have produced a series of anti-DNA mAbs and then monoclonal anti-idiotypic Ab directed against idiotypic determinant of the 3D8 mAb that has the highest affinity to dsDNA and ssDNA among the anti-DNA mABs that we had obtained. The spleen cells of the MRL-Ipr/Ipr, autoimmune prone, mice were fused with P3X63Ag8.653 myeioma cells to obtain anti-DNA Ab secreting hybridomas. Out of the fourteen clones that showed strong binding to ssDNA, four clones had cross-reactivity with dsDNA whereas none of these clones reacted with left-handed z-DNA. The binding activities of the anti-DNA mAbs to various synthetic polynucleotide sequences were different respectively. Anti-idiotypic mAbs were generated by the fusion of myeloma cells and spleen cells from the Balb/c mice immunized with 3DB-Fab. We have produced two anti-idiotypic mAbs, B7 (IgG2a/k) and 02F3 (IgM/k), which were specific to 3DB-Fab and cloned the variable region of the heavy chain from the 02F3 hybridoma.  Korean J. Immunol. 20, 2: 109-117, 1998

5류마티스양 관절활막세포의 증식과 싸이토카인 , 단백분해 효소의 발현에 미치는 TGF-B , GM-CSF , PDGF 의 영향

저자 : 노용균(Yong Gyun Rho) , 유수진(Su Jin Yu) , 전현주(Hyeon Joo Cheon) , 손정원(Jeong Won Sohn)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 119-127 (9 pages)

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To investigate effects of cytokines on rheumatoid synovial cells, proliferation and expression of cytokine and metalloproteinase genes were studied with the primary culture of rheumatoid synovial cells which was treated with TNF-a, GM-CSF, TGF-a, PDGF and IL-B. By [3H] thymidine incorporation assay, TGF-B and PDGF increased proliferation of synovial cells by 1.5 and 2.5 folds respectively. Cytokine gene expression was assessed by RT-PCR. Rheumatoid synovial cells expressed constitutively TGF-B and IL-B at a high level and IL-1B, GM-CSF, and MIP-1a at a relatively low level. TGF-B, GM-CSF and PDGF increased IL-B expression. Expression of pro-inflammatory cytokines and chemokines was increased by GM-CSF and PDGF. Both GM-CSF and PDGF increased the expression of IL-1B, GM-CSF MIP-la and IL-8. In addition, GM-CSF enhanced expression of TNF-a. Stromelysin and collagenase are the major proteinases responsible for destruction ot joints in rheumatoid arthritis (RA). These genes were expressed constitutivefy in rheumatoid synovial cells. In summary, PDGF and GM-CSF may piay an important role by inducing or increasing expression of IL-1B, TGF-B and PDGF by increasing proliferation of rheumatoid synovial cells.  Korean J. Immunol. 20, 2: 119-127, 1998

6이종이식의 면역반응에서 Cobra Venom Factor 의 역할에 관한 연구

저자 : 한덕종(Duck Jong Han) , 김송철(Song Cheol Kim) , 장혁재(Hyuk Jae Jang) , 위유미(Yu Mee Wee) , 이장혁(Jang Hyuk Lee) , 박희영(Hee Yung Park) , 유은실(Eun Sil Yu)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 129-139 (11 pages)

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Recently xenotransplantation has been thought as a final solution for the controi of donor organ shortage in allograft. In order to be a ciinicai entity, xenotransplantation has many obstacles such as hyperacute rejection and delayed xenogratt rejection as a potent immunologic reaction, zoonosis and ethical problems. We already reported the eariy immunoiogic events occuring soon after xenograft in animal model, in which natural antibody and complement have a crucial roie in rejection response. As a further step for the prolongation of graft survival, we used anticomplement agent (cobra venom factor, CVF) in the same model. Graft survival in discordant (guinea pig-to-rat) xenogratt was extended from 30.6 minutes to 2 days following singie injection of CVF, which showed similar pattern of rejection with the concordant xenogratt in terms of time of rejection response after grafting. In this setting antibody response in the blood did not show any difference between that of pre CVF and post CVF, even though IgM response was more pronounced than IgG. The complement activity in the blood showed marked suppression following CVF injection. Intragraft complement gene (C3 mRNA) expression in CVF injected discordant showed delayed response in a similar pattern like that of concordant xenograft. Interestingly enough intragraft anticomplement gene expression showed the simiiar pattern of response with the complement. From these results we can conclude that anticomplement agent (CVF) extended the graft survival in discordant xenograft upto the level of concordant xenograft by shifting the complement activation response from that of discordant to concordant xenograft.  Korean J. Immunol. 20, 2: 129-139, 1998

7결핵균체 TSP 항원의 대식세포 활성기전

저자 : 박성규(Seong Kyu Park) , 조은경(Eun Kyeong Jo) , 임재현(Jae Hyun Lim) , 김화중(Hwa Jung Kim) , 박정규(Jeong Kyu Park) , 백태현(Tae Hyun Paik)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 141-151 (11 pages)

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Present study aimed to investigate the immunological activities of cell wall associated protein antigen solubilized with Triton X-100 (TSP) from Mycobacterium tuberculosis H37Rv and conducted on 43 patients with pulmonary tuberculosis (newly diagnosed, medicated within 12 months and chronic refractory patients) and 17 normal healthy controls. These immunological responses were compared with those induced by the PPD or 30 kDa antigen from M, tuberculosis H37Rv culture filtrates, identified as biologically important secreted proteins. Proliferative responses to mycobacterial antigens were compared in peripheral blood mononuclear cells (PBMC) of healthy subjects and pulmonary tuberculosis patients. Signiticant blastogenic responses to the TSP were observed in healthy tuberculin reactors, newly diagnosed and some of antituberculosis drug-medicated patients by H-thymidine incorporation assay. IL-12 p40 and IFN-r mRNA expressions to the TSP were markedly increased, whereas IL-10 and TNF-a mRNA expressions were decreased at a 5 day-stimulation by PBMC in healthy tuberculin reactors, newly diagnosed and medicated patients. However, patients with chronic refractory tuberculosis exhibited more depressed IL-12 p40 and IFN-r mRNA expressions to all of the antigens than another groups. Interestingly, very low IL-10 and TNF-a mRNA expressions cultured with the TSP were also shown. These data suggest that the TSP may be involved in the macrophage activation by induction of Th1 stimulatory signals, such as IL-12, and suppression of Th1 inhibitory cytokine, IL-10. Korean J. Immunol. 20, 2: 141-151, 1998

8매독균 47 kDa 항원에 의한 치료전 매독 환자의 세포성 면역반응 유도

저자 : 조은경(Eun Kyeong Jo) , 임재현(Jae Hyun Lim) , 김화중(Hwa Jung Kim) , 박정규(Jeong Kyu Park) , 백태현(Tae Hyun Paik) , 이민걸(Min Geol Lee) , 이정복(Jung Bock Lee) , 남현희(Hyun Hee Nam) , 민들레(Dul Lei Min) , 송영자(Young Ja Song)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 153-162 (10 pages)

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Present study was aimed to investigate the immunological activities of the 47 kDa glycoprotein antigen from Treponema pallidum and conducted on 24 patients with syphilis, (early, late, spontaneously healed, congenital and treated patients) and on 17 normal healthy controls. Two opposite lymphoproliferative manifestations to the 47 kDa antigen were observed in syphilis patients by H-thymidine incorporation assay. Ten responders (stimulation index [Sl] >4) showed a 3-fold-higher proliferation than the nonresponders, and four of those responders were spontaneously healed patients. Furthermore, analysis by flow cytometry indicated a preferential expansion of CD4' T lymphocytes by the 47 kDa antigen in the spontaneously healed syphilis patients. Stimulation of PBMCs of spontaneously healed syphilis patients with the 47 kDa antigen for greater than 72 hrs resulted in piogressive augmentation of IFN-r, IL-2Ra and IL-2 mRNA measured by RT-PCR, but considerably reduced IL-4 and IL-10 mRNA expression. However, patients with late latent syphilis exhibited more increased IL-4 and IL-10 mRNA expressions in response to the 47 kDa antigen than spontaneously healed syphilis group. In contrast to other groups, when cultured with the 47 kDa antigen very low IFN-#y, IL-2Ra and IL-2 mRNA expressions were shown in early syphilis group. These data suggest that the Th1-predominant cellular responses induced by the 47 kDa antigen may be involved in the clinical outcome of syphilis and provide the immunologic basis for further functional studies regarding the role of the 47 kDa in the immunopathogenesis of syphilis. Koreen J. Immunol. 20, 2: 153  162, 1998

9집먼지 진드기에 감작된 마우스에서 전신성 과민반응 유발과 면역학적 관점

저자 : 이봉기(Bong Ki Lee) , 이숙이(Sook Yi Yi) , 장윤수(Yun Soo Jang) , 박중원(Chung Won Park) , 홍천수(Chun Soo Hong)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 163-170 (8 pages)

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We have used BALB/c mice as an animal model for the study of anaphylactic hypersensitivity to the house dust mite. For the sensitization, BALB/c mice were injected with a single dose of extracts of Oermatophagoides farinae (D. pa) or Dermatophagoides pteronyssinus (D. pt) mixed with adjuvants (aluminum hydroxide and Bordetella pertussis) intraperitonealy. On days of 15, 30, and 60 after the sensitization, the mice received a challenge dose of the same allergen intravenously to induce anaphylactic shock. The hypersensitivity reactions were scored by anaphylactic shock. And various immunological parameters, including cytokines and immunoglobulin isotypes, were studied in relation with the shock. A high level of anaphylactic shock was produced in the mice by both of the allergens, D, fa and D, pt, at 15 and 30 days after sensitization. In vitro Ag specific proliferative reponses of spleen cells from D. pt treated mice (D. pt mice) was six times higher than those from O. fa treated mice (O. fa mice). Regardless the differences in antigens, the production of IFN-r by spleen cells from D. pt mice or O. fa mice was equally high at 15 days after sensitization. However, the ability to produce IFN-r by the spleen cells from D, pt mice was three times higher compared to that from D. fa mice. The production of IL-4 by the spleen cells was enhanced slightly but not significant in both groups. In studies of the allergen-specific immunoglobulin isotypes in the sera of the mice, the level of IgE in both groups was enhanced slightly but not significant. In contrast, the level of IgG subtypes were increased in both groups. When the levels of IgG were compared by subtypes, the level of IgG1 increased significantly on day 15 when the anaphylactic shock score was maximized in both groups. Increase in IgG2a level at the day was not significant, instead, asignificant increase in IgG2 levels was observed on day 60 after sensitization when the anaphylaxis was almost discontinued. Although a higher level of IgG3 was examined on day 15 and 30 in D. pt mice and on day 60 in D, fa mice, anaphylaxis was not appeared to be associated with the levels of IgG3 in this study. The IgG1, rather than IgE, was assumed to the major factor involved in the anaphylactic response observed in this experiment. In conclusion, BALB/c mice would be an animal model for the study of anaphylactic hypersensitivity to D. fa or D, pt., which might be an essential tool for the future development of immuno-therapeutic agents.  Korean J. Immunol. 20, 2: 163-170, 1998

10열상 처치에 따른 백혈구의 수 및 분포의 변화

저자 : 남상윤(Sang Yun Nam)

발행기관 : 대한면역학회 간행물 : 대한면역학회지 20권 2호 발행 연도 : 1998 페이지 : pp. 171-177 (7 pages)

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Regarding numerical changes of leukocytes involved in immune defects following thermal injury, a lot of controversial results have been reported. In this study, the changes of leukocyte number and distribution were examined and compared in spleen and lymph nodes of thermally injured mice. Mice (Balb/c) were anesthetized by intraqeritoneal injection of 2,2,2-tribromoethanol and thermally injured by immersion of hair-removed dorsal skin (15% total body surface) in a boiling water bath (96`C) for 7 seconds. Both of lymph node cell (LNC) and spleen cell (SPC) numbers decreased significantly at day 2 of injury and thereafter rebounded, but in a distinct pattern; 1) LNC numer returned to over normal level at day 6 and normalized again, whereas SPC number increased gradually over normal level and sustained until day 24 of injury. 2) Such increase of LNC and SPC number coincided with higher proportion of PMN and relative decline of lymphacytes, particularly CD3 T cells rather than slg' B cells, but such alteration was more significant in spleen. The changes of peripheral blood leukocyte (PBL) number was comparable to those of SPC. These data suggest that the cause of immune modulation in thermally injured mice acts systemically. In addition, it is noteworthy that reduction of lymphocyte and CD3 T cell proportions was due to relative increase of PMN number, not the decrease of absolute number of lymphocytes. Spontaneous recovery of injured mice in this study also implicates that increase of PMN number may be responsible for recovery from injury without infection. Finally, the CD4'/CD8' ratio of injured mice was lower only at day 2 ot injury, but not significantly, than that of control group. It is likely that contribution of Th/Ts ratio to immune defect after thermal injury should be determined together with other factors, such as injured body surface % and severity of injury. Korean J. Immunol. 20, 2: 171-177, 1998

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KCI등재 SCOUPUS

Journal of Bacteriology and Virology
41권 4호 ~ 41권 4호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
42권 4호 ~ 42권 4호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
42권 3호 ~ 42권 3호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
42권 1호 ~ 42권 1호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
42권 2호 ~ 42권 2호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
41권 3호 ~ 41권 3호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
41권 2호 ~ 41권 2호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
41권 1호 ~ 41권 1호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
40권 4호 ~ 40권 4호

KCI등재 SCOUPUS

Journal of Bacteriology and Virology
40권 3호 ~ 40권 3호
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

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