Gastric motor dysfunction and concomitent gastric stasis have been implicated in the pathogenesis of non-ulcer dyspepia (NUD), but the cause-and-effect relationship is not established. In order to identify the relationship between nonspecific upper gastrointestinal symptoms and gastric emptying time in the patients with NUD, gastric emptying scan using 99mTc-tincolloid labelled chicken liver as solid test meal was performed on 20 healthy volunteers and 20 patients with NUD. The patients with NUD were subgrouped according to symptoms and the gastric emptying time of subgroups were compared. The results were as follows: The mean percentage of remnant radioisotope content in stomach is significantly high at 60 through 180 minutes after test meal in the patients with NUD, as compared with normal volunteers (p<0.01), The GET (T 1/2) was significantly delayed in patients with NUD (107.9+-17.5min), as compared with normal volunteer (90.15+-6.03min)(p<0.01). The GET was significantly delayed in the subgroup of NUD as compared with normal volunteers (p<0.01) and significantly delayed in the subgroup of dysmoltility-like dyspepsia (117.6+-22.25 min) as compared with the subgroups of ulcer-like dyspepsia (99.6+-10.25min) or reflux-like dyspepsia (103.0+-9.97 min)(p<0.01). ln conclusion, the scintigraphic measurement of gastric emptying time using radioisotope labelled solid meal is safe and convenient method to evaluate NUD. and above results suggest that delayed gastric emptying has important pathogenetic role in NUD.