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대한피부과학회> 대한피부과학회지> 기저세포암 , 우췌상암 및 에크린 한선낭종을 동반한 피지선 모반

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기저세포암 , 우췌상암 및 에크린 한선낭종을 동반한 피지선 모반

Nevus Sebaceus associated with Basal Cell Carcinoma , Verrucous Carcinoma and Eccrine Hidrocystoma

이주희(Joo Hee Lee) , 김홍석(Hong Suk Kim) , 정한길(Han Gil Jung) , 유대현(Dae Hyun Yoo) , 이민걸(Min Geol Lee)
  • : 대한피부과학회
  • : 대한피부과학회지 38권8호
  • : 연속간행물
  • : 2000년 08월
  • : 1085-1088(4pages)

DOI


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N/A
Nevus sebaceus has a well-documented neoplastic potential, and multiple tumors arising in nevus sebaceous have been reported. However, the development of three or more tumors is extremely rare. We report a case of nevus sebaceus in a 56-year-old male associated with basal cell carcinoma, verrucous carcinoma and eccrine hidrocystoma.

UCI(KEPA)

I410-ECN-0102-2009-510-004771449

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2020
  • : 9429


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1입원중 피부과로 의뢰된 환자의 통계분석 ( 96년-99년 )

저자 : 함정희(Jung Hee Ham) , 조소연(So Yeon Jo) , 황규광(Gyu Gwang Hwang) , 김문정(Moon Jung Kim)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1007-1015 (9 pages)

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Background: Dermatologic practice occurs mainly in the outpatient setting. The reasons for, frequency, and impact of inpatient dermatologic consultation may be quite different from outpatient practice and there has been a lot of changes in dermatologic consultation recently. Several studies about characteristics of dermatologic consultation have been reported. Objectives : The purpose of this study was to examine the characteristics of inpatient dermatologic consultation in Ewha womans university hospital for 3 years and also to compare the result of the report in 1991. Methods: During a period of 3 years (1996.2-1998.3), we prospectively recorded the demographics of the patients for whom consultation was requested, the final diagnosis of the dermatologic service, and the tests necessary to arrive at diagnosis, and reasons for dermatologic consultation. Results : 1) The consulted patients were 1019 among 38,402 inpatients (2.7%). 2) The total number of male and female patients were 547(53.7%) and 472(46.3%), respectively (M:F = 1.2:1). 3) The most frequent age group was the 6th decade(18.4%) and the highest incidence of seasonal distribution was spring. 4) The patients in internal medicine were the most frequently consulted. 5) The most common dermatoses were eczema group, followed by drug eruption, fungal infection, viral infection, acne vulgaris, urticaria, etc. 6) Distribution of dermatoses according to seasons and individual departments was statistically different in various dermatoses. 7) Frequent causes of consultation were as follows: the dermatologic diseases or conditions 68.3%, the diseases related to treatment 12.3%, the skin lesions of systemic diseases 10.0%, the dermatologic tests 3.5%, and admission to other departments with dermatologic diseases 1.9%, respectively. 8) The rate of consultation for drug eruption was increased markedly compared to that of new patients at OPD in 1998. Conclusions: The characteristics of inpatient dermatologic consultation in our hospital have been changed and furthermore the characteristics were quite different from that of oupatient practice.

2피부 림프구 증식성 질환에서 Epstein-Barr Virus의 표현에 관한 연구

저자 : 원영호(Young Ho Won) , 하상근(Sang Geun Ha) , 이지범(Je Bum Lee) , 김성진(Sung Jin Kim) , 이승철(Seung Chul Lee) , 박창수(Chang Soo Park)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1016-1023 (8 pages)

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Backgranoud: Epstein-Barr virus is a member of the Herpesviridae the latent infection of which has been implicated in certain cutaneous lymphoproliferative disorders including various cutaneous T cell lymphoma, lymphomatoid granulomatosis, lymphomatoid papulosis, angiocentric lymphoma, cytopathic histiocytic panniculitis, papulovesicular lesions of the face. However, EBV expression in skin disorders is variable according to researchers and geographic location. In addition, their biologic significance and a related mechanism at developing the disorders remain unclear, Ohjective & Methods : To examine the significance of EBV infection, in situ hybridization for EBV-encoded small RNA (EBER 1) and immunohistiochemical stain for LMP-1, bc1-2, p53 were done in formalin-fixed paraffin tissues. Also the clinical findings are reviewed to observe a clinical correlation to expressions of EBER ISH and other markers. Results : Mycosis fungoides patients was 17 cases, Four cases(24%) among them were positive in EBER ISH, all of which found at a tumorous lesion, but did not have any relationship to disease duration and clinical staging. Positive percent of LMP-1, bc1-2, p53 were respectively 39%(9/23), 43%(10/43), 13(3/23). A positive relation with EBER ISH reactivity appear on specially LMP-1, but did not in bcl-2 and p53. Five cases of angiocentric lymphoma were positive in EBER ISH and reveal a poor clinical course. Two out of three diffuse large cell lymphoma were reactive with EBER ISH. The most of latter two disorders were reactive with both of LMP-1 and p53. Conclusion: This study presumed that EBV infection may have a relation with pathomechanism and prognosis of some cutaneous T cell lymphoma.

3에크린 한선 종양의 CD44 isoform 발현에 관한 면역조직화학적 연구

저자 : 김시용(Si Yong Kim) , 최규철(Gyu Chul Choi) , 정병수(Byung Soo Jung)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1024-1029 (6 pages)

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Background: CD44 is the principal cell surface receptor for hyaluronate and exists as multiple isoforms generated by the alternative splicing of up to 10 variant exons. Although certain isofroms may play a role in tumor progression and metastasis formation, the precise function and expression of the variant isoforms are less clear. Since on normal eccrine glands CD44 standard isoform(CD44s) is expressed only in eccrine coil secretory cells, it can be considered as a possible marker of this type of differentiation. However little is known about the expression of CD44 variant isofroms(CD44v) in eccrine gland tumors. Objective : The purpose of this study was to investigate the immunohistochemical expression of different CD44 isoforms(CD44s, CD44v4, CD44v6) in the eccrine gland tumors. Methods : Formalin-fixed and paraffin-embedded tissues from 2 cases of eccrine hidrocystoma, 5 cases of syringoma, 2 cases of eccrine poroma, 2 cases of syringofibroadenoma, 2 cases of nodular hidradenoma were immunolabelled with monoclonal antibody directed CD44s, CD44v4, and CD44v6. Results : Except for syringofibroadenoma, the most tumors cells with eccrine ductal differentiation showed negative staining for CD44s, and positive staining for CD44v4 and CD44v6. Syringofibroadenoma exhibited positive staining for CD44s and CD44v4, but negative staining for CD44v6. Eccrine poroma showed negative staining for CD44s, positive staining for CD44v4, and variable intensity of staining for CD44v6 in different areas of the tumors. In case of nodular hidradenoma, small tubular lumina and clear cells were positive for CD44s. Conclusion: Our results suggest that CD44 isoforms can not be a useful marker for an eccrine gland tumor with specific differentiation, but its characteristic pattern of distribution might reflect the variety of functional roles of CD44 isoforms in tumorigenesis of eccrine gland tumors.

4과립세포종의 임상 및 병리조직학적 연구

저자 : 이미우(Mi Woo Lee) , 최지호(Ji Ho Choi) , 성경제(Gyung Je Sung) , 문기찬(Gee Chan Moon) , 고재경(Jae Gyung Ko)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1030-1036 (7 pages)

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Background: Granular cell tumor is a rare neoplasm with characteristic histopathologic morphology. There were no comprehensive studies about the features of granular cell tumor in Korea. Objective: Our purpose was to find the clinical, pathological and immunohistochemical features of granular cell tumor. Methods: The sixteen patients with granular ce11 tumor seen at our institution over a 10-year period were retrieved. Clinical records and pathology slides of the patients were reviewed retrospectively. Results and Conclusion: 1. Granular cell tumor is rare, with a frequency of 0.006% of all surgical specimen. 2. Skin and subcutaneous tissues are the most predilection sites, and esophagus or gastric walls are the second common sites. 3. There are no multifocal cases and only one case of malignant granular cell tumor. 4. Granular cell lesions from many different sites share similar light microscopic features. 5. The Schwann cell origin of the tumor is demonstrated by reactivity with S-100 protein.

5분절형 백반증과 비분절형 백반증의 임상 양상에 대한 비교 연구

저자 : 방장석(Jang Suk Bang) , 이정우(Jung Woo Lee) , 김태훈(Tae Hun Kim) , 성열오(Yeol Oh Sung) , 한승경(Seung Gyung Han)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1037-1044 (8 pages)

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Background: Vitiligo was divided into two types, segmental and non-segmental vitiligo. Objective: The purpose of our study is to investigate the clinical differences of segmental and non-segmental vitiligo. Methods : A cross-sectional study, using standard questionnaire items on 1190 cases of vitiligo was performed. Results : The results were summarized as follows I. The non-segmental vitiligo was 2.4fold more common than segmental vitiligo. 2. The mean age of onset was older in non-segmental vitiligo than in segmental vitiligo. 3. The mean duration was longer in non-segmental vitiligo. 4. The depigmented area was larger in non-segmental vitiligo. 5. The incidences of Koebner phenomenon, progressiveness and mucosal involvement were more common in non-segmental vitiligo. 6. There were no differences about sex ratio, blood typing, family history, and associated disorders. Conclusion: Segmental and non-segmental vitiligo differ substantially in various clinical manifestations, which suggests that two types of vitiligo have different pathogenic mechanism.

6유방외 Paget병의 임상적 연구

저자 : 이미우(Mi Woo Lee) , 최지호(Ji Ho Choi) , 성경제(Gyung Je Sung) , 문기찬(Gee Chan Moon) , 고재경(Jae Gyung Ko)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1045-1049 (5 pages)

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Background: Extramammary Paget's disease (EMPD) is a rare skin neoplasm usually observed in apocrine-bearing regions. There were no comprehensive studies about the clinical features of EMPD in Korea. Objeetive: Our purpose was to study in detail the clinical findings of EMPD. Methods: The fifteen patients with EMPD at our institution over ten years were retrieved. Clinical records and pathology slides of the patients were reviewed retrospectively. Results: l. EMPD was seen more frequently in men than women (14:1 male:female ratio). 2. The most predilection site was penoscrotal area. 3. Thirteen percent of patients (2/15) with the disease had an associated underlying malignancy. 4. Twenty-two percent (2/9) of patients with wide excision had local recurrence during the follow-up period. Conclusion: EMPD in Korea may be characterized by male predominance and penoscrotal location. The incidence of concomitant malignancy may be lower than that in Caucasian. However, a search for internal malignancy and regular follow-up is still warranted.

7전방 대대 병사들에서 족부백선 유병률

저자 : 서구일(Goo Il Seo) , 김정애(Jung Ae Kim) , 임정구(Jung Goo Lim) , 은희철(Hee Chul Eun) , 윤재일(Jae Il Yoon)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1050-1054 (5 pages)

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Background: It has been widely accepted that the prevalence of tinea pedis in soldiers may be higher due to their occlusive army boots and communal baths. Objective : Our study was designed to investigate the prevalence of tinea pedis in Korean soldiers monthly throughout the year by the rank. of the soldiers and also to verify whether tinea pedis is one of the occupational diseases in Korean soldiers. Methods : We examined the feet of soldiers in a battalion monthly throughout the year. On those with suspected skin lesions, microscopic examinations along with fungus cultures were performed in July, 1996. Results: Average prevalence of tinea pedis throughout the year was 51.5% on clinical examination. The highest prevalence was 74.0% in August and the lowest in February by 36.7% The prevalence of tinea pedis by rank was 38.3%(18/47) in the new private group, 61.7%(29/47) in the private group, 84.8%(67/79) in the private 1st class group, 72.4%(55/76) in the corporal group and 70.9%(39/55) in the sergeant group in July, 1996. Dermatophytes were demonstrated microscopically in 59.1%(123/208) of the specimens examined. Cultures were positive in 93 cases, i.e., from 44.7% of those examined. Conclusion: The major factor contributing to the highest prevalence of tinea pedis in August among the months of the year seems to be the hot and damp weather conditions(especially in July and August). Considering the fact that the prevalence of tinea pedis in winter season was also higher by 36.7-40.2%, Korean soldiers seem to possess higher risk of tinea pedis due to their tight-fitting army boots. The spread of infection among non-infected soldiers might have resulted from the communal bath and Korean traditional habit of taking-off their shoes in a large dormitory where they sleep together. Moreover, the fact that the prevalence of tinea pedis increases markedly with their ranks suggests that tinea pedis should be considered as an occupational disease among Korean soldiers.

8이형성 모반의 임상 및 병리조직학적 고찰 - 15 예에 대한 고찰 -

저자 : 신상부(Sang Boo Shin) , 이동원(Dong Won Lee) , 이준영(Jun Young Lee) , 조백기(Baek Gee Jo)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1055-1062 (8 pages)

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Background: The dysplastic nevus is a rare form of melanocytic nevus, but the clinical criteria and histopathologic finding are still debated. There are no studies of dysplastic nevus in korea except a few case reports. Objective : This study was aimed to evaluate the clinical and histopathological characteristics of dysplastic nevus developed in korean. Methods: We reviewed the clinical and histopathologic finding of 15 patients diagnosed as dysplastic nevus on the biopsy. Results : The result were as follows; 1. The incidence of dysplastic nevus in our study was 9.9 cases/100,000 population 2. The subjects consisted of 9 males and 6 females. 3. The common onset of age was 11-20. 4. The common site of dysplastic nevus was the trunk. 5. The common pattern of lesional change was asymmetry and color variegation. 6. The common clinical findings of the dysplastic nevus was multiple, 5-12mm size, multipapular surface, ill-demarcated margin and brown/black color. 7. The pathologic findings including shoulder phenomenon, melanocytic nest, patchy lymphohistiocytic infiltration, melanophage, scattered atypical epitheloid cell, random atypia, anisokaryosis and no mitosis was shown in all the patients, but eosinophilic hyperplasia was shown in 13 patients. 8. The mild atypia in the Duke grading system was the most common. There was significant positive correlation between architectural and cytologic scores(Pearson correlation test, P<0.05, r=0.97). Conclusion : Although the incidence of the dysplastic nevus in our study was much lower than that of the west, the clinicopathologic findings were not different.

9손바닥과 발바닥에 발생한 양성 멜라닌 세포성 종양에 대한 임상 및 병리조직학적 연구

저자 : 조재주(Jae Joo Jo) , 전덕규(Duk Gyu Jeon) , 이용석(Yong Suk Lee) , 서승리(Seung Ree Seo) , 김방순(Bang Soon Kim) , 조광현(Gwang Hyun Jo) , 한광호(Gwang Ho Han)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1063-1069 (7 pages)

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Background: The incidence of malignant melanoma in oriental countries is lower than that in western countries. But recently the incidence of malignant melanoma and related death rate are increasing in the world. Malignant melanoma on the palm and sole is known to have worse prognosis and sometimes radical surgery such as amputation is necessary. It is important to exclude malignant melanoma when pigmented patch is encountered, and biopsy is necessary in most cases. But histopathological features of benign melanocytic neoplasms occurring at palm or sole are known to be confusing, because they can resemble the features of malignant melanoma. But there has been no report on this item in Korean dermatological literature, to our knowledge. Objectives : We investigated the histopathological features of benign melanocytic neoplasms on the palm and sole with their clinical features. Materials & Methods : A total of 23 benign melanocytic neoplasms that had been excised from the palm and sole at Inje University Sanggye Paik Hospital and Seoul National University Hospital between July 1991 and April 1998 were evaluated. The retrospective analysis of the clinical manifestation was performed. Histologically, hematoxylin and eosin stained tissue sections were reviewed with the following criteria: symmetry, circumscription, lentiginous hyperplasia, anastomosing rete ridges, pagetoid spread, papillary dermal fibroplasia, lymphocytic infiltrate, pigment in the dermis and the stratum corneum, cytologic atypia, and mitotic activity. Results : Five patients were male and eighteen were female; the mean age was 27.6 years with a peak incidence in the fourth decades. Six lesions had asymmetric, irregular and geographic borders. The diameter of the lesions varied; 3 cases were larger than 9 mm in maximum diameter. Clinically, we suspected 7 cases to be malignant mlanoma before biopsy. Histological diagnoses of 23 benign melanocytic neoplasms were as follows: 12 junctional nevi, 3 compound nevi, 1 intradermal nevus, 2 lentigines, 3 benign melanocytic hyperplasias, and 2 congenital melanocytic nevi. Microscopic findings showed single melanocytic proliferation at the dermo-epidermal junction in 17 cases(73.9%), lentiginous hyperplasia in 8 cases, upward migration of melanocytes in 8 cases(34.7%), and ill-defined lateral circumscription in 6 cases(26.0%). Mitotic figures and cytologic atypia were not present. Pigments were variously seen in the stratum corneum in all cases and conspicuous amounts of melanin where the melanocytes upwardly migrated were found in 8 cases. Conclusion : There has been a report that the diameter of lesions is very important in differential diagnosis of malignant melanoma when a pigmented lesion is present on the palm and sole and 9mm is the critical maximum diameter. But we encountered 3 cases of benign melanocytic neoplasm which were larger than 9mm in their diameters. We think 9mm is not a reliable critical diameter in the differential diagnosis of malignant melanoma. Histological analysis showed some features resembling malignant melanoma, such as single melanocytic hyperplasia, upward migration of melanocytes in epidermis, ill-defined lateral margin, abundant pigments in the stratum corneum, and lymphocytic infiltration in dermis. There was no case with cytological atypia or mitoses and we think this is an important feature to be studied in the future in the differentiation of malignant melanoma.

10피부 유육종증 7 예

저자 : 김대호(Dae Ho Kim) , 박영민(Young Min Park) , 강훈(Hun Kang) , 조상현(Sang Hyun Jo) , 최성우(Sung Woo Choi) , 변대규(Dae Gyu Byun) , 조백기(Baek Gee Jo)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 38권 8호 발행 연도 : 2000 페이지 : pp. 1070-1074 (5 pages)

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We report seven cases of cutaneous sarcoidosis without systemic involvement. All cases showed specific skin lesions which were papules (2 cases), patches (2 cases), subcutaneous nodules (2 cases) and plaques (1 case), respectively. Histologic examinations of the specimens commonly showed typical noncaseating granulomas. Although we performed the various laboratory studies, there was no evidence of systemic involvement in any case. Treatment with intralesional and/or topical steroid resulted in good responses, but we experienced some relapses of the skin lesions after withdrawal of treatment. Excision was the choice of treatment for subcutanous nodules. During the follow-up periods (1 - 4 years), we could not find any evidence of systemic involvement. Our cases represent the unusual cases of cutaneous sarcoidosis without systemic involvement.

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KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 5호 ~ 32권 5호

KCI등재 SCOUPUS

대한피부과학회지
58권 8호 ~ 58권 8호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 3호 ~ 46권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 7호 ~ 58권 7호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 4호 ~ 32권 4호

KCI등재 SCOUPUS

대한피부과학회지
58권 6호 ~ 58권 6호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 2호 ~ 46권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 5호 ~ 58권 5호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 3호 ~ 32권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 4호 ~ 58권 4호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 1호 ~ 46권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 3호 ~ 58권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 2호 ~ 32권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 2호 ~ 58권 2호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
45권 4호 ~ 45권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 1호 ~ 32권 1호

KCI등재 SCOUPUS

대한피부과학회지
58권 1호 ~ 58권 1호

KCI등재 SCOUPUS

대한피부과학회지
57권 10호 ~ 57권 10호

프로그램북(구 초록집)
71권 1호 ~ 71권 1호

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